Detecting p53 Immunoexpression inEsophageal Mucosa with Exfoliative Cytologyin Individuals at Risk for Squamous CellCarcinoma of the Esophagus

Lopes, Antônio B.; Müller, L.; Reichert, Roberta; Moraes, Cláudia M.; Capra, Anderson M.; Prolla, João Carlos; Diehl, Ada R.S.; Meurer, Luíse; Barros, Sérgio Gabriel Silva de; Fagundes, Renato Borges

doi:10.1159/000324963

Cited by 3 publications

(1 citation statement)

References 23 publications

(23 reference statements)

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“…Impaired p53 activity promotes the accumulation of DNA damage in cells without the induction of apoptosis. Commonly, p53 mutations appear to serve as a crucial early event in malignant transformation of Barrett's oesophagus and dysplastic squamous lesions to OAC and OSCC, respectively [173,174]. In addition, mutational status and p53 overexpression in oesophageal tumours have been correlated with poor survival and poor response to CRT in both OAC and OSCC [24,25,175,176].…”

Section: P53mentioning

confidence: 99%

Prognostic features of the tumour microenvironment in oesophageal adenocarcinoma

McShane

Arya

Stewart

et al. 2021

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Section: P53mentioning

confidence: 99%

Prognostic features of the tumour microenvironment in oesophageal adenocarcinoma

McShane

Arya

Stewart

et al. 2021

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Concerns about pooled performances of cytology for esophageal squamous cell carcinoma screening

Gao

Wang

2023

Gastrointestinal Endoscopy

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Esophageal squamous cell carcinoma - precursor lesions and early diagnosis

Lopes

Fagundes²

2012

WJGE

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Squamous cell carcinoma of the esophagus (SCCE) carries a poor prognosis due to late diagnosis. Early detection is highly desirable, since surgical and endoscopic resection offers the only possible cure for esophageal cancer. Population screening should be undertaken in high risk areas, and in low or moderate risk areas for people with risk factors (alcoholics, smokers, mate drinkers, history of head and neck cancer, achalasia and lye stricture of the esophagus). Esophageal balloon cytology is an easy and inexpensive sampling technique, but the current methods are insufficient for primary screening due to sampling errors. Conventional endoscopy with biopsy remains the standard procedure for the identification of pre-malignant and early malignant changes in esophageal mucosa and endoscopic detection. It may be enhanced by several techniques such as dye and optic chromoendoscopy, magnifying endoscopy, and optical-based spectroscopic and imaging modalities. Since more than 80% of SCCE deaths occur in developing countries, where expensive techniques such as narrow band imaging (NBI) and autofluorescence imaging are unavailable, the most cost-effective tool for targeting biopsies may be Lugol dye chromoendoscopy, since it is easy, accurate, inexpensive and available worldwide. In ideal conditions, or in developed countries, is it reasonable to think that optimal detection will require a combination of techniques, such as the combination of Lugol's chromoendoscopy and NBI to identify esophageal areas that require further characterization by a high resolution technique. The efficacy and cost-effectiveness will determine whether these modalities will become part of standard endoscopy practice.

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Detecting p53 Immunoexpression inEsophageal Mucosa with Exfoliative Cytologyin Individuals at Risk for Squamous CellCarcinoma of the Esophagus

Cited by 3 publications

References 23 publications

Prognostic features of the tumour microenvironment in oesophageal adenocarcinoma

Prognostic features of the tumour microenvironment in oesophageal adenocarcinoma

Concerns about pooled performances of cytology for esophageal squamous cell carcinoma screening

Esophageal squamous cell carcinoma - precursor lesions and early diagnosis

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