Detecting optic nerve lesions in clinically isolated syndrome and multiple sclerosis: double-inversion recovery magnetic resonance imaging in comparison with visually evoked potentials

Riederer, Isabelle; Mühlau, Mark; Hoshi, Muna-Miriam; Zimmer, Claus; Kleine, Justus F.

doi:10.1007/s00415-018-9114-2

Cited by 22 publications

(24 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the choice of all acquisition parameters was based on well-established criteria 3 and was supported by the published literature on DIR with and without T2P module. 33,37,43 of restoring the quality of highly accelerated acquisitions with otherwise low SNR, 18 ID did not provide obvious further improvements in MS lesion detection in our case of high-quality input images. Further studies shall assess whether ID applied to highly accelerated T2PDIR could enable similar lesion detection performance in a shorter time.…”

Section: Discussionmentioning

confidence: 52%

See 1 more Smart Citation

Improved detection of multiple sclerosis lesions with T2‐prepared double inversion recovery at 3T

Costagli

Lapucci

Zacà

et al. 2022

Journal of Neuroimaging

View full text Add to dashboard Cite

Background and Purpose: Double inversion recovery (DIR) imaging is used in multiple sclerosis (MS) clinical protocols to improve the detection of cortical and juxtacortical gray matter lesions by nulling confounding signals originating from the cerebrospinal fluid and white matter. Achieving a high isotropic spatial resolution, to depict the neocortex and its typically small lesions, is challenged by the reduced signal-to-noise ratio (SNR) determined by multiple tissue signal nulling. Here, we evaluate both conventional and optimized DIR implementations to improve tissue contrast (TC), SNR, and MS lesion conspicuity.Methods: DIR images were obtained from MS patients and healthy controls using both conventional and prototype implementations featuring a T2-preparation module (T2P), to improve SNR and TC, as well as an image reconstruction routine with iterative denoising (ID). We obtained quantitative measures of SNR and TC, and evaluated the visibility of MS cortical, cervical cord, and optic nerve lesions in the different DIR images.Results: DIR implementations adopting T2P and ID enabled improving the SNR and TC of conventional DIR. In MS patients, 34% of cortical, optic nerve, and cervical cord lesions were visible only in DIR images acquired with T2P, and not in conventional DIR images. In the studied cases, image reconstruction with ID did not improve lesion conspicuity.Conclusions: DIR with T2P should be preferred to conventional DIR imaging in protocols studying MS patients, as it improves SNR and TC and determines an improvement in cortical, optic nerve, and cervical cord lesion conspicuity.

show abstract

Section: Discussionmentioning

confidence: 52%

“…to study optic nerve pathology, [33][34][35][36][37] with a better representation of lesions than other MR techniques. 7,38 Here, we demonstrated the utility of the T2P module, which further improved optic nerve lesion conspicuity with respect to the conventional DIR implementation, at no cost in terms of additional scanning time.…”

Section: Discussionmentioning

confidence: 99%

Improved detection of multiple sclerosis lesions with T2‐prepared double inversion recovery at 3T

Costagli

Lapucci

Zacà

et al. 2022

Journal of Neuroimaging

View full text Add to dashboard Cite

show abstract

“…Finally, automated diagnostic models, including the one proposed, should be adapted to other sequences with improved optic nerve imaging (e.g. double inversion recovery sequences ( Riederer et al, 2019 )).…”

Section: Discussionmentioning

confidence: 99%

Detection of lesions in the optic nerve with magnetic resonance imaging using a 3D convolutional neural network

Martí-Juan

Frías²,

García-Vidal³

et al. 2022

NeuroImage: Clinical

View full text Add to dashboard Cite

“…Furthermore, 3D-DIR is more sensitive and specific than STIR for the diagnosis of ON, with sensitivity of 95% and specificity of 94%. DIR-hyperintense optic nerve lesions [18] are more specific and accurate for optic nerve lesions, especially in patients with multiple sclerosis. Notably however, cortical lesions and cortical microinfarcts cannot be well differentiated on DIR in older patients with multiple sclerosis or patients with vascular risk factors [19].…”

Section: Optimized Image Qualitymentioning

confidence: 99%

Recent advances in magnetic resonance imaging of optic neuritis

Zhang

Xian

2020

Chin J Acad Radiol

View full text Add to dashboard Cite

Optic neuritis is a common cause of vision loss, but it is difficult to visualize the lesion well via conventional magnetic resonance imaging due to its small size and oblique orientations of the optic nerves. Some advanced techniques have been introduced into clinical practice in recent decades. Herein we review recent advances in magnetic resonance imaging techniques that are useful in cases of optic neuritis.

show abstract

Detecting optic nerve lesions in clinically isolated syndrome and multiple sclerosis: double-inversion recovery magnetic resonance imaging in comparison with visually evoked potentials

Cited by 22 publications

References 16 publications

Improved detection of multiple sclerosis lesions with T2‐prepared double inversion recovery at 3T

Improved detection of multiple sclerosis lesions with T2‐prepared double inversion recovery at 3T

Detection of lesions in the optic nerve with magnetic resonance imaging using a 3D convolutional neural network

Recent advances in magnetic resonance imaging of optic neuritis

Contact Info

Product

Resources

About