Detecting Latent Tuberculosis Infection Prior to Kidney Transplantation in a Tertiary Hospital in Saudi Arabia: Comparison of the T-SPOT.TB Test and Tuberculin Test

Hassan, Hoda I.

doi:10.9734/bmrj/2013/2926

Cited by 7 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The overall agreement between TST and QFT was 72%, that can be considered as fair, when many previous international studies reported moderate or fair agreement only between both the tests [ 18 – 20 ]. Supportively, recent studies from Saudi Arabia on dialysis patients also showed 75.5% and 90.9% agreement between TST and QFT/TSPOT Assay respectively [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 78%

Interferon Gamma Release Assay versus Tuberculin Skin Testing among Healthcare Workers of Highly Diverse Origin in a Moderate Tuberculosis Burden Country

et al. 2016

View full text Add to dashboard Cite

Health care workers (HCW’s) are always at an increased risk of contracting tuberculosis (TB) infection. In Saudi Arabia, Interferon Gamma Release Assay (IGRA) has not been evaluated as a screening tool for latent TB infection (LTBI) among HCW’s considering their high demographic diversity. During February 2012 to January 2015 a cross sectional study has been conducted in a tertiary care center with maximum demographically diverse staff population in the capital city-Riyadh. After a short interview and consenting, all the candidates were subjected to tuberculin skin test (TST) and QuantiFERON TB gold In-tube test (QFT). A logistic regression analysis was carried out for establishing the associations between putative risk factors and the diagnostic tests. The candidates were classified according to geographical origin and a detailed analysis was conducted on the impact of their origin towards the results of TST and QFT. Of the 1595 candidates enrolled, 90.6% were BCG vaccinated, female (67.9%) and mainly nurses (53.2%). Candidates with high risk of suspected or confirmed TB patient exposure were 56.1% and 76.5% of them had <10 year’s work experience. TST positivity was observed in 503 (31.5%) candidates, while QFT was positive among 399 (25%). Majority of the candidates were non-Saudi (83%) and predominantly (52.4%) from Western Pacific region. Concordant results were obtained in 14.2% of positive cases and 57.7% negative cases. The disagreements between the two tests were relatively high (kappa co-efficient-0.312±0.026, p value- <0.00001) as TST positive/QFT negative discordance was 54.8% while TST negative/QFT positive discordance was 15.7%. Age of the candidates, BCG vaccination, and South East Asian origin were associated with TST positivity while Occupational TB exposure and geographical origin of the candidates were associated with QFT positivity. A regular follow up on recently TST converted candidates showed no progression to active TB. The putative factors associated with the discordance were origin of the candidate (p value <0.001), profession (p value-0.001), BCG vaccination (p value-0.001) and occupational TB exposure level (P value-0.001). The study demonstrated high level prevalence of LTBI among the demographically diverse study candidates. The agreement between QFT and TST was poor, thus QFT alone cannot be recommended in our setting for a routine LTBI screening. Origin of the candidates has strong association with the results of TST and QFT. The discordant results particularly TST negative and QFT positive needs more detailed analysis.

show abstract

Section: Discussionmentioning

confidence: 78%

Interferon Gamma Release Assay versus Tuberculin Skin Testing among Healthcare Workers of Highly Diverse Origin in a Moderate Tuberculosis Burden Country

et al. 2016

View full text Add to dashboard Cite

show abstract

“…However, a recent study reported 75.5% (Ä = 0.34) agreement between TST and QFT-G results among 200 dialysis patients with a positive TST rate of 13% and positive QFT-G rate of 32.5% [26]. Another study reported 90.9% (Ä = 0.46) agreement between TST and T-SPOT among 44 kidney donors and 60.15% (Ä = 0.07) agreement between the two tests among 133 hemodialysis patients, with 40% of them having discordant results between TST and T-SPOT [27]. However, the sample sizes of both studies were small, and the findings cannot be safely projected to HCWs.…”

Section: Discussionmentioning

confidence: 99%

Pre-employment screening of latent tuberculosis infection among healthcare workers using tuberculin skin test and QuantiFERON-TB Gold test at a tertiary care hospital in Saudi Arabia

El-Helaly

Khan

El-Saed

et al. 2014

Journal of Infection and Public Health

View full text Add to dashboard Cite

show abstract

“…Our subjects were studied prospectively and are the most recent representative sample when compared to previous studies in Saudi Arabia, where subjects were enrolled either retrospectively, or before the date of this study. 3 , 35 , 36 , 37 The window period required for QFT to be positive post-exposure was carefully considered when subjects were enrolled in the study since TB exposure within 3 months was the criteria for enrollment. Our results reflect LTBI with little likelihood of false positive and false negative with IGRA specificity of 98.1% and a sensitivity of 89.0%.…”

Section: Discussionmentioning

confidence: 99%

Screening of latent tuberculosis infection among health care workers working in Hajj pilgrimage area in Saudi Arabia, using interferon gamma release assay and tuberculin skin test

Bukhary

Amer

Emara

et al. 2018

Annals of Saudi Medicine

View full text Add to dashboard Cite

BACKGROUNDInterferon gamma release assays (IGRA) is highly specific for Mycobacterium tuberculosis and is the preferred test in BCG-vaccinated individuals. The few studies that have screened health care workers (HCWs) in Saudi Arabia for latent tuberculosis infection (LTBI) using IGRA have varied in agreement with the traditional tuberculin skin test (TST).OBJECTIVEAssess the prevalence of LTBI among HCWs working in the Hajj pilgrimage using IGRA and TST and measuring their agreement.DESIGNCross-sectional prospective.SETTINGMultiple non-tertiary care hospitals.PATIENTS AND METHODSHCWs who worked during the Hajj pilgrimage in Saudi Arabia in December 2015. Data was collected by standardized questionnaire. Samples were drawn and analyzed by standard methods.MAIN OUTCOME MEASURESThe prevalence of LTBI among HCW and the agreement by kappa statistic between QFT-GIT and TST.SAMPLE SIZE520 subjects.RESULTSThe sample included 30.7% nurses and 19.2% physicians. The majority were BCG vaccinated (98.5%). There were a total of 56 positive by QFT-GIT and the LTBI rate was 10.8%. In 50 QFT positive/476 TST negative the LTBI rate was 10.5% in discordant tests, and in 6 QFT positive/44 TST positive it was 13.6% in concordant tests. The overall agreement between both tests was poor—83% and kappa was 0.02. LTBI prevalence was associated with longer employment (13.1 [9.2] years). The QFT-GIT positive test was significantly higher in physicians (P=.02) and in HCWs working in chest hospitals 16/76 (21.05%) (P=.001).CONCLUSIONAgreement between the tests was poor. QFT-GIT detected LTBI when TST was negative in HCWs who had a history of close contact with TB patients.LIMITATIONSA second step TST was not feasible within 2–3 weeks.

show abstract

Detecting Latent Tuberculosis Infection Prior to Kidney Transplantation in a Tertiary Hospital in Saudi Arabia: Comparison of the T-SPOT.TB Test and Tuberculin Test

Cited by 7 publications

References 0 publications

Interferon Gamma Release Assay versus Tuberculin Skin Testing among Healthcare Workers of Highly Diverse Origin in a Moderate Tuberculosis Burden Country

Interferon Gamma Release Assay versus Tuberculin Skin Testing among Healthcare Workers of Highly Diverse Origin in a Moderate Tuberculosis Burden Country

Pre-employment screening of latent tuberculosis infection among healthcare workers using tuberculin skin test and QuantiFERON-TB Gold test at a tertiary care hospital in Saudi Arabia

Screening of latent tuberculosis infection among health care workers working in Hajj pilgrimage area in Saudi Arabia, using interferon gamma release assay and tuberculin skin test

Contact Info

Product

Resources

About