This study was designed to investigate the frequency and pattern of orthostatic symptoms during head-up tilt (HUT) in patients with orthostatic intolerance during daily life, and to identify the relationship between the orthostatic symptoms during HUT and autonomic parameters. We prospectively collected autonomic data from 464 patients with orthostatic symptoms. Adrenergic and cardiovagal function tests including HUT were performed. Based on HUT results, we divided patients into orthostatic hypotension (OH), postural tachycardia syndrome (POTS), or normal HUT groups. We also investigated orthostatic symptoms during HUT. Only 25% of the patients reported orthostatic symptoms during HUT and 75% were asymptomatic. Typical orthostatic symptoms such as orthostatic dizziness and blurred vision, and atypical symptoms like chest tightness and headache occurred in 86% and 66%, respectively. Patients with POTS had symptoms more frequently than patients with OH during HUT. There were no differences in degrees of BP or HR changes between symptomatic and asymptomatic groups within the OH and POTS groups. HUT fails to reproduce symptoms of orthostatic intolerance in the majority of patients. Clinicians need to be aware that most patients with OH are asymptomatic during HUT and patients with POTS are more likely to be symptomatic than patients with OH.Orthostatic symptoms are defined as symptoms that occur when upright and are relieved by recumbence. Common orthostatic symptoms are dizziness, lightheadedness, weakness or tiredness, cognitive difficulties, blurred vision, anxiety, tremulousness, palpitations, nausea, clamminess, or sweating 1, 2 . Two orthostatic intolerance syndromes, orthostatic hypotension (OH) and the postural tachycardia syndrome (POTS), are thought to be responsible for these symptoms. Head-up tilt (HUT) is a standard test to evaluate orthostatic intolerance. However, even in a well-defined group of patients with orthostatic symptoms and documented OH, reproducibility of OH with HUT is relatively low 3 . Furthermore, patients with prominent OH during HUT can have no symptom during daily life (i.e., asymptomatic OH) 1 or during HUT (i.e., hypotension unawareness) 4 . This discordance may relate to multiple mechanisms causing OH and the origin of orthostatic intolerance. Hence, we undertook a study with the following goals. First, we undertook a battery of autonomic function tests to separate these patients into categories of OH, POTS, and normal autonomic function. Second, we evaluated the ability of HUT to reproduce symptoms of orthostatic intolerance. Third, we evaluated if symptoms related to severity of autonomic failure.
MethodsWe prospectively collected data from a series of consecutive patients with orthostatic symptoms who were seen in the Dongsan Medical Center Autonomic Reflex Laboratory from March 2014 to June 2015. We included all patients who experienced orthostatic symptoms while they were sitting or standing within the previous 6 months. We excluded patients under 10 years old. A standardize...