Detecting ICRS grade 1 cartilage lesions in anterior cruciate ligament injury using T1ρ and T2 mapping

Nishioka, Hiroaki; Hirose, Jun; Nakamura, Eiichi; Okamoto, Naoya; Karasugi, Tatsuki; Taniwaki, Takuya; Okada, Tatsuya; Yamashita, Yasuyuki; Mizuta, Hiroshi

doi:10.1016/j.ejrad.2013.04.038

Cited by 28 publications

(22 citation statements)

References 29 publications

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“…This study agrees with multiple other publications that demonstrate the use of T2/T1ρ relaxation times for the early detection of knee OA[13,21,22]. The unique contribution is the comparison of normal or near normal imaging samples between cases and controls.…”

Section: Discussionsupporting

confidence: 91%

“…Thuillier et al[23] examined patients with patellar-femoral pain but without radiographic evidence of knee OA and found significantly elevated T1ρ values in the lateral patellar cartilage compared to controls. Several other studies have also showed that focal cartilage defects identified on arthroscopy are correlated with elevated MRI relaxation times[22,24,25]. We have similarly shown that morphologically normal articular cartilage, though adjoining osteoarthritic compartments of the knee, exhibit early changes in cartilage degeneration.…”

Section: Discussionsupporting

confidence: 79%

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T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis

Kester

Carpenter

et al. 2017

WJO

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AIMTo investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees.METHODSMagnetic resonance (MR) images were acquired from 5 subjects scheduled for total knee arthroplasty (TKA) (mean age 70 years) and 20 young healthy control subjects without knee pain (mean age 28.9 years). MR images of T1ρ mapping, T2 mapping, and fat suppressed proton-density weighted sequences were obtained. Following TKA each condyle was divided into 4 parts (distal medial, posterior medial, distal lateral, posterior lateral) for cartilage analysis. Twenty specimens (bone and cartilage blocks) were examined. For each joint, the degree and extent of cartilage destruction was determined using the Osteoarthritis Research Society International cartilage histopathology assessment system. In magnetic resonance imaging (MRI) analysis, 2 readers performed cartilage segmentation for T1ρ/T2 values and cartilage thickness measurement.RESULTSEleven areas in MRI including normal or near normal cartilage thickness were selected. The corresponding histopathological sections demonstrated mild to moderate osteoarthritis (OA). There was no significant difference in cartilage thickness in MRI between control and advanced OA samples [medial distal condyle, P = 0.461; medial posterior condyle (MPC), P = 0.352; lateral distal condyle, P = 0.654; lateral posterior condyle, P = 0.550], suggesting arthritic specimens were morphologically similar to normal or early staged degenerative cartilage. Cartilage T2 and T1ρ values from the MPC were significantly higher among the patients with advanced OA (P = 0.043). For remaining condylar samples there was no statistical difference in T2 and T1ρ values between cases and controls but there was a trend towards higher values in advanced OA patients.CONCLUSIONThough cartilage is morphologically normal or near normal, degenerative changes exist in advanced OA patients. These changes can be detected with T2 and T1ρ MRI techniques.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 79%

T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis

Kester

Carpenter

et al. 2017

WJO

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“…T 1ρ ‐weighted imaging has been extensively used in the past decades to assess pathology of liver, muscle, breast, brain, and tumor besides those of human MSK system . These studies have demonstrated the potential values of T 1ρ imaging for evaluating various physiologic and pathologic states.…”

Section: Future Prospectsmentioning

confidence: 99%

T_1ρ MRI of human musculoskeletal system

Wang

Regatte

2014

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) offers the direct visualization of human musculoskeletal (MSK) system, especially all diarthrodial tissues including cartilage, bone, menisci, ligaments, tendon, hip, synovium etc. Conventional MR imaging techniques based on T1- and T2-weighted, proton density (PD) contrast are inconclusive in quantifying early biochemically degenerative changes in MSK system in general and articular cartilage in particular. In recent years, quantitative MR parameter mapping techniques have been used to quantify the biochemical changes in articular cartilage with a special emphasis on evaluating joint injury, cartilage degeneration, and soft tissue repair. In this article, we will focus on cartilage biochemical composition, basic principles of T1ρ MR imaging, implementation of T1ρ pulse sequences, biochemical validation, and summarize the potential applications of T1ρ MR imaging technique in MSK diseases including osteoarthritis (OA), anterior cruciate ligament (ACL) injury, and knee joint repair. Finally, we will also review the potential advantages, challenges, and future prospects of T1ρ MR imaging for widespread clinical translation.

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“…1). For instance, T 2 and T 1ρ relaxation time mapping are commonly applied together in clinical studies [98, 99•], and sometimes provide different results among study participants [100]. An interventional study utilizing both dGEMRIC and T 2 relaxation time mapping suggests that dGEMRIC may be more sensitive to the earliest biochemical changes in cartilage [101], possibly attributable to the suggestion that GAG loss precedes breakdown of the collagen matrix in OA [56].…”

Section: Future Considerationsmentioning

confidence: 99%

Imaging Strategies for Assessing Cartilage Composition in Osteoarthritis

et al. 2014

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Efforts to reduce the ever-increasing rates of osteoarthritis (OA) in the developed world require the ability to non-invasively detect the degradation of joint tissues before advanced damage has occurred. This is particularly relevant for damage to articular cartilage because this soft tissue lacks the capacity to repair itself following major damage and is essential to proper joint function. While conventional magnetic resonance imaging (MRI) provides sufficient contrast to visualize articular cartilage morphology, more advanced imaging strategies are necessary for understanding the underlying biochemical composition of cartilage that begins to break down in the earliest stages of OA. This review discusses the biochemical basis and the advantages and disadvantages associated with each of these techniques. Recent implementations for these techniques are touched upon, and future considerations for improving the research and clinical power of these imaging technologies are also discussed.

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Detecting ICRS grade 1 cartilage lesions in anterior cruciate ligament injury using T1ρ and T2 mapping

Cited by 28 publications

References 29 publications

T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis

T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis

T_1ρ MRI of human musculoskeletal system

Imaging Strategies for Assessing Cartilage Composition in Osteoarthritis

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Detecting ICRS grade 1 cartilage lesions in anterior cruciate ligament injury using T1ρ and T2 mapping

Cited by 28 publications

References 29 publications

T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis

T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis

T1ρ MRI of human musculoskeletal system

Imaging Strategies for Assessing Cartilage Composition in Osteoarthritis

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T_1ρ MRI of human musculoskeletal system