In this paper, we introduce a novel human interaction detection approach, based on CALIPSO (Classifying ALl Interacting Pairs in a Single shOt), a classifier of humanobject interactions. This new single-shot interaction classifier estimates interactions simultaneously for all humanobject pairs, regardless of their number and class. State-ofthe-art approaches adopt a multi-shot strategy based on a pairwise estimate of interactions for a set of human-object candidate pairs, which leads to a complexity depending, at least, on the number of interactions or, at most, on the number of candidate pairs. In contrast, the proposed method estimates the interactions on the whole image. Indeed, it simultaneously estimates all interactions between all human subjects and object targets by performing a single forward pass throughout the image. Consequently, it leads to a constant complexity and computation time independent of the number of subjects, objects or interactions in the image. In detail, interaction classification is achieved on a dense grid of anchors thanks to a joint multi-task network that learns three complementary tasks simultaneously: (i) prediction of the types of interaction, (ii) estimation of the presence of a target and (iii) learning of an embedding which maps interacting subject and target to a same representation, by using a metric learning strategy. In addition, we introduce an object-centric passive-voice verb estimation which significantly improves results. Evaluations on the two well-known Human-Object Interaction image datasets, V-COCO and HICO-DET, demonstrate the competitiveness of the proposed method (2nd place) compared to the state-ofthe-art while having constant computation time regardless of the number of objects and interactions in the image.This work proposes a new interaction detection approach, named CALIPSO (Classifying ALl Interacting Pairs in a Single shOt) which complexity is independent of the number of interactions. The proposed model simultaneously estimates all interactions between all objects with a