Detecting functional magnetic resonance imaging activation in white matter: Interhemispheric transfer across the corpus callosum

Mazerolle, Erin L.; D’Arcy, Ryan C.N.; Beyea, Steven

doi:10.1186/1471-2202-9-84

Cited by 55 publications

(70 citation statements)

References 52 publications

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“…The majority of subjects (six) had activation in posterior CC regions (isthmus or splenium), consistent with previous results (Mazerolle et al, 2008). However, four of these subjects also had anterior CC activation.…”

Section: Discussionsupporting

confidence: 81%

“…The previous study employed a more typical T2 weighted fMRI acquisition and reported a considerably lower percentage of individuals with CC activation (21% versus the 80% reported here; Mazerolle et al, 2008). It is possible that the increased sensitivity provided by ASE spiral fMRI acquisition and increased T2 weighting ( and [Gawryluk et al, 2009a]) allowed detection of white matter activation not only in more subjects, but also across a larger region of the corpus callosum.…”

Section: Discussionmentioning

confidence: 94%

“…The participants performed an established interhemispheric transfer task (Mazerolle et al, 2008). Stimuli consisted of faces (right hemisphere stimuli) and words (left hemisphere stimuli) that were presented to the left and right visual fields (i.e., either directly to the relatively specialized hemisphere, or to the opposite hemisphere) in order to elicit interhemispheric transfer.…”

Section: Experimental Designmentioning

confidence: 99%

“…Such tasks, in which functionally lateralized stimuli (words and faces) are presented to the right and left visual hemifields, have been used to study disconnection syndromes in split brain patients (Gazzaniga, Bogen, and Sperry, 1965) and have been previously developed for fMRI (D'Arcy et al, 2006). Mazerolle et al (2008) reported activation in the isthmus of the corpus callosum in 21% of individuals. Group level activation was also observed in this region, but at relaxed statistical thresholds (p < 0.005, uncorrected).…”

Section: Introductionmentioning

confidence: 99%

“…Despite these issues, there is no direct evidence that precludes the possibility of detecting white matter fMRI activation. It has been suggested that the energy-dependent processes that take place in white matter may result in task-dependent changes, which could be measured with fMRI ( [Mazerolle et al, 2008] and [Tettamanti et al, 2002]). …”

Section: Introductionmentioning

confidence: 99%

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Confirming white matter fMRI activation in the corpus callosum: Co-localization with DTI tractography

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 94%

Section: Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Confirming white matter fMRI activation in the corpus callosum: Co-localization with DTI tractography

et al. 2010

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Voxelwise and skeleton‐based region of interest analysis of fetal alcohol syndrome and fetal alcohol spectrum disorders in young adults

Li¹,

Coles²,

Lynch³

et al. 2009

Human Brain Mapping

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Though fetal alcohol syndrome and fetal alcohol spectrum disorders are among the most common developmental disorders, their understanding is incomplete. Diffusion tensor imaging, which is sensitive to microstructural organization in white matter, may provide a relevant measure in this population demonstrating incompletely characterized white matter pathology. In this study, tractbased spatial statistics routine and a skeleton-based region of interest analyses were employed to detect differences in diffusion tensor imaging derived metrics between young adults who were alcohol exposed and an unexposed control group. Participants include twenty-eight with dysmorphic features associated with fetal alcohol syndrome, twenty-nine who were prenatally exposed but do not show physical effects, and twenty-five with the same low socioeconomic status but unexposed. The tract-based spatial statistics analysis revealed a statistically significant decrease in fractional anisotropy at the isthmus of the corpus callosum and its connected callosal fibers in dysmorphic individuals relative to controls (cluster-wise p FWE < 0.05). This finding was consistent with that of the follow-up skeleton-based region of interest analysis (F (2,79) =3.256, p=0.044). In addition, the patterns in axial and radial diffusivity changes suggest that demyelination may be associated with the degraded white matter integrity observed in the dysmorphic group.

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Regional and network properties of white matter function in Parkinson's disease

Cuiping

Liu

et al. 2018

Human Brain Mapping

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Parkinson's disease (PD) is a neurodegenerative disorder with dysfunction in cortices as well as white matter (WM) tracts. While the changes to WM structure have been extensively investigated in PD, the nature of the functional changes to WM remains unknown. In this study, the regional activity and functional connectivity of WM were compared between PD patients (n = 57) and matched healthy controls (n = 52), based on multimodel magnetic resonance imaging data sets. By tract‐based spatial statistical analyses of regional activity, patients showed decreased structural‐functional coupling in the left corticospinal tract compared to controls. This tract also displayed abnormally increased functional connectivity within the left post‐central gyrus and left putamen in PD patients. At the network level, the WM functional network showed small‐worldness in both controls and PD patients, yet it was abnormally increased in the latter group. Based on the features of the WM functional connectome, previously un‐evaluated individuals could be classified with fair accuracy (73%) and area under the curve of the receiver operating characteristics (75%). These neuroimaging findings provide direct evidence for WM functional changes in PD, which is crucial to understand the functional role of fiber tracts in the pathology of neural circuits.

show abstract

Detecting functional magnetic resonance imaging activation in white matter: Interhemispheric transfer across the corpus callosum

Cited by 55 publications

References 52 publications

Confirming white matter fMRI activation in the corpus callosum: Co-localization with DTI tractography

Confirming white matter fMRI activation in the corpus callosum: Co-localization with DTI tractography

Voxelwise and skeleton‐based region of interest analysis of fetal alcohol syndrome and fetal alcohol spectrum disorders in young adults

Regional and network properties of white matter function in Parkinson's disease

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