Detecting cancerous human liver cells with high performances using photonic crystals

Soltani, Osswa; Francoeur, S.; Kanzari, M.

doi:10.1016/j.physb.2022.414557

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…This gives the average sensitivity of around 1806nm/RIU, which is much higher than recently reported values [19,20]. Moreover, the structure possesses a very high FOM of around Finally, the normalized electric field within the proposed structure is also calculated.…”

Section: Discussionmentioning

confidence: 63%

Design of graded topological resonator for sensitivity improvement

Goyal,

Dash,

Saini

et al. 2023

Optoelectronic Devices and Integration XII

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In this paper, a hyperbolic-graded topological nanophotonic resonator is proposed to excite topologically protected edge states (TES). The index grading is introduced to modify the dispersion characteristics and enhance the mode field confinement of TES. The optimized structure leads to the excitation of a TES at a 1521nm operating wavelength. Further, the structural capability of the refractive index sensor is demonstrated. The analytical results demonstrate a sensitivity of 1806 nm/RIU (with a refractive index range from 1.35 to 1.40). Thus, showing its potential to detect and sense various biochemical analytes accurately.

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Section: Discussionmentioning

confidence: 63%

Design of graded topological resonator for sensitivity improvement

Goyal,

Dash,

Saini

et al. 2023

Optoelectronic Devices and Integration XII

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“…For example, the Jurkat cell or blood cancer has a refractive index of 1.39 with an 80% concentration, while its normal cell refractive index is 1.376 [51,52]. Also, the refractive index of Cervical cancer with an 80% concentration is 1.392, as shown in Table . III and its normal cell refractive index is 1.368 with 30-70% concentration of the mentioned sample [47,[53][54][55][56][57]. The refractive index of Adrenal Gland Cancer is 1.395 with an 80% concentration, and its normal cell owns a RI of 1.381 in the 30-70% concentration [58].…”

Section: Resultsmentioning

confidence: 99%

Ultrasensitive and label-free, graphene/CaF2 multilayer-based biosensor for detecting gasses, cancers, viruses, and diabetes, with significant improvement of sensitivity, quality factor, and figure of merit

Jafari,

Gholizadeh,

Zhoulideh

et al. 2023

Preprint

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One of the primary goals for the researchers is to create a high-quality sensor with a simple structure because of the urgent requirement to identify biomolecules at low concentrations to diagnose diseases and detect hazardous chemicals for health early on. Recently graphene has attracted much interest in the field of improved biosensors. Meanwhile, graphene with new materials such as CaF2 has been widely used to improve the applications of graphene-based sensors. Using the fantastic features of the graphene/CaF2 multilayer, this article proposes an improvement sensor in the sensitivity (S), the figure of merit (FOM), and the quality factor (Q). The proposed sensor is based on the five-layers graphene/dielectric grating integrated with a Fabry-Perot cavity. By tuning graphene chemical potential (µc), due to the semi-metal features of graphene, the surface plasmon resonance (SPR) waves excited at the graphene/dielectric boundaries. Due to the vertical polarization of the source to the gratings and the symmetry of the electric field, both corners of the grating act as electric dipoles, and this causes the propagation of plasmonic waves on the graphene surface to propagate towards each other. Finally, it causes Fabry-Perot (FP) interference on the surface of graphene in the proposed structure's active medium (the area where the sample is located). In this article, using the inherent nature of FP interference and its S to the environment's refractive index (RI), by changing a minimal amount in the RI of the sample, the resonance wavelength (interferometer order) shifts sharply. The proposed design can detect and sense some cancer, such as Adrenal Gland Cancer, Blood Cancer, Breast Cancer I, Breast Cancer II, Cervical Cancer, and skin cancer precisely. By optimizing the structure, we can achieve an S as high as 9000 nm/RIU and a FOM of about 52.14 for the first resonance order (M1). Likewise, the remarkable S of 38000 nm/RIU and the FOM of 81 have been obtained for the second mode (M2). In addition, the proposed label-free SPR sensor can detect changes in the concentration of various materials, including gases and biomolecules, hemoglobin, breast cancer, diabetes, leukemia, and most alloys, with an accuracy of 0.001. The proposed sensor can sense urine concentration with a maximum S of 8500 nm/RIU and cancers with high S in the 6000 nm/RIU range to 7000 nm/RIU. Also, four viruses, such as M13 bacteriophage, HIV type one, Herpes simplex type 1, and influenza, have been investigated, showing Maximum S (for second resonance mode of λR(M2) of 8000 nm/RIU (λR(M2) = 11.2 µm), 12000 nm/RIU (λR(M2) = 10.73 µm), 38000 nm/RIU (λR(M2) = 11.78 µm), and 12000 nm/RIU (λR(M2) = 10.6 µm), respectively, and the obtained S for first resonance mode (λR(M1)) for mentioned viruses are 4740 nm/RIU (λR(M1) = 8.7 µm), 8010 nm/RIU (λR(M1) = 8.44 µm), 8100 nm/RIU (λR(M1) = 10.15 µm), and 9000 (λR(M1) = 8.36 µm), respectively.

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