Detecting Alzheimer’s Disease Stages and Frontotemporal Dementia in Time Courses of Resting-State fMRI Data Using a Machine Learning Approach

Sadeghi, Mohammad Amin; Stevens, Daniel; Kundu, Shinjini; Sanghera, Rohan; Dagher, Richard; Yedavalli, Vivek; Jones, Craig; Sair, Haris; Luna, Licia P.; ,

doi:10.1007/s10278-024-01101-1

J Digit Imaging. Inform. med.

2024

DOI: 10.1007/s10278-024-01101-1

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Detecting Alzheimer’s Disease Stages and Frontotemporal Dementia in Time Courses of Resting-State fMRI Data Using a Machine Learning Approach

Mohammad Amin Sadeghi,

Daniel Stevens,

Shinjini Kundu

et al.

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Cited by 2 publications

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Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge

Gorini,

Tonacci

2024

Antioxidants

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Frontotemporal dementia (FTD) includes a number of neurodegenerative diseases, often with early onset (before 65 years old), characterized by progressive, irreversible deficits in behavioral, linguistic, and executive functions, which are often difficult to diagnose due to their similar phenotypic characteristics to other dementias and psychiatric disorders. The genetic contribution is of utmost importance, although environmental risk factors also play a role in its pathophysiology. In fact, some metals are known to produce free radicals, which, accumulating in the brain over time, can induce oxidative stress, inflammation, and protein misfolding, all of these being key features of FTD and similar conditions. Therefore, the present review aims to summarize the current evidence about the environmental contribution to FTD―mainly dealing with toxic metal exposure―since the identification of such potential environmental risk factors can lead to its early diagnosis and the promotion of policies and interventions. This would allow us, by reducing exposure to these pollutants, to potentially affect society at large in a positive manner, decreasing the burden of FTD and similar conditions on affected individuals and society overall. Future perspectives, including the application of Artificial Intelligence principles to the field, with related evidence found so far, are also introduced.

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Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge

Gorini,

Tonacci

2024

Antioxidants

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Resistance Exercise Training as a New Trend in Alzheimer’s Disease Research: From Molecular Mechanisms to Prevention

Sepúlveda-Lara,

Sepúlveda,

Marzuca-Nassr

2024

IJMS

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Alzheimer’s disease is a pathology characterized by the progressive loss of neuronal connections, which leads to gray matter atrophy in the brain. Alzheimer’s disease is the most prevalent type of dementia and has been classified into two types, early onset, which has been associated with genetic factors, and late onset, which has been associated with environmental factors. One of the greatest challenges regarding Alzheimer’s disease is the high economic cost involved, which is why the number of studies aimed at prevention and treatment have increased. One possible approach is the use of resistance exercise training, given that it has been shown to have neuroprotective effects associated with Alzheimer’s disease, such as increasing cortical and hippocampal volume, improving neuroplasticity, and promoting cognitive function throughout the life cycle. However, how resistance exercise training specifically prevents or ameliorates Alzheimer’s disease has not been fully characterized. Therefore, the aim of this review was to identify the molecular basis by which resistance exercise training could prevent or treat Alzheimer’s disease.

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Detecting Alzheimer’s Disease Stages and Frontotemporal Dementia in Time Courses of Resting-State fMRI Data Using a Machine Learning Approach

Cited by 2 publications

References 54 publications

Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge

Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge

Resistance Exercise Training as a New Trend in Alzheimer’s Disease Research: From Molecular Mechanisms to Prevention

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