Detecting abnormalities of corpus callosum connectivity in autism using magnetic resonance imaging and diffusion tensor tractography

Structural Network Topology Revealed by White Matter Tractography in Cannabis Users: A Graph Theoretical Analysis

“…Taken together, our findings suggest that CB subjects have a less efficiently integrated and more locally segregated structural brain network with altered regional network attributes across some brain regions. The number of fiber tracts between regions varies with the degree of anisotropy such as FA and MD, and can reveal disease-specific abnormalities in the brain [e.g., autism (Hong et al, 2011) and tumor (Roberts et al, 2005)]. In this study, the number of connections within the network was significantly decreased in CB users, while preserving mean connection weights (Fig.…”

Assessment of white matter integrity of autistic preschool children with diffusion weighted MR imaging

“…Lower FA within most of the white matter regions correlated with more diagnostic symptoms scored using the ADI-R ICD-10 algorithm [32]. There is negative correlation between the fiber number of the anterior third corpus callosum and scores on the CARS (r = À0.503, P = 0.033) [46].…”

“…Neuro-pathological studies showed reduced cell size, less dendritic branching of the white matter and poor grey and white matter boundaries. In addition, abnormal levels of neurotrophic factors such as serotonin during brain development could result in disrupted white matter development [25,46].…”

“…The white matter abnormalities in these regions of the brain provided potential neurobiological markers of autism that implicated in the pathophysiology of the disease [21,26,29]. There is significantly less white matter density in the anterior third of the corpus callosum, and higher ADC and lower fiber number values of the anterior third transcallosal fiber tracts [46].…”

A CAD system for early diagnosis of autism using different imaging modalities.

“…The FA was reduced in the ASD group for the short range, but not long range fibers, and the necessity of advanced DTI technology to re-examine the short range connectivity in ASD was indicated. The brain connectivity in the corpus callosum of the HFA patients was examined in [191] by measuring both the DTI and T1 MRI. The corpus callosum volume and density extracted from the MRI were compared to the FA, MD, average fiber length, and fiber number obtained from the DTI by deterministic tractography.…”