Detecting a single nanoparticle by imaging the localized enhancement and interference of surface plasmon polaritons

Sun, Xiaopeng; Liu, Hongyao; Jiang, Liwen; Wei, Ruxue; Wang, Xue; Wang, Chang; Lu, Xinchao; Huang, Chengjun

doi:10.1364/ol.44.005707

Cited by 17 publications

(11 citation statements)

References 14 publications

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“…Figure 3a-d shows the imaging of single PS nanospheres with diameters of 500, 400, 200, and 100 nm under TM illumination. All the images show similar characteristics to those of SPP-based leakage radiation imaging [13][14][15][16]. The central bright dot and the parabolic fringes were introduced by the localized enhancement and interference of evanescent waves.…”

Section: Methodssupporting

confidence: 58%

“…Leakage radiation microscopy is also a label-free imaging method that utilizes the inherent leakage radiation of surface plasmon polaritons (SPPs), directly imaging near-field SPPs propagating at the air-metal interface to far-field [11]. By imaging the interaction between SPPs and adsorbed objects at the interface, leakage radiation microscopy is used for the fast and label-free detection of single polystyrene (PS) and silica nanoparticles [12][13][14], the single influenza virus [15], single exosomes [16], and single DNA molecules [17], as well as tracking the membrane proteins [18] and organelles [19] in living cells. Although leakage radiation microscopy is label-free and high sensitivity, the Au film for SPP excitation imposes a strict limitation on the substrate.…”

Section: Introductionmentioning

confidence: 99%

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Label-Free Imaging of Single Nanoparticles Using Total Internal Reflection-Based Leakage Radiation Microscopy

et al. 2020

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Label-free, fast, and single nanoparticle detection is demanded for the in situ monitoring of nano-pollutants in the environment, which have potential toxic effects on human health. We present the label-free imaging of single nanoparticles by using total internal reflection (TIR)-based leakage radiation microscopy. We illustrate the imaging of both single polystyrene (PS) and Au nanospheres with diameters as low as 100 and 30 nm, respectively. As both far-field imaging and simulated near-field electric field intensity distribution at the interface showed the same characteristics, i.e., the localized enhancement and interference of TIR evanescent waves, we confirmed the leakage radiation, transforming the near-field distribution to far-field for fast imaging. The localized enhancement of single PS and Au nanospheres were compared. We also illustrate the TIR-based leakage radiation imaging of single polystyrene nanospheres with different incident polarizations. The TIR-based leakage radiation microscopy method is a competitive alternative for the fast, in situ, label-free imaging of nano-pollutants.

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Section: Methodssupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Label-Free Imaging of Single Nanoparticles Using Total Internal Reflection-Based Leakage Radiation Microscopy

et al. 2020

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“…The wavevector, propagation length and propagation direction of launched SPPs have been obtained from the Fourier space interferometric imaging [9]. The size-dependent localized field enhancement of the silica and polystyrene particles has been used to determine the particle diameters [2,10]. Moreover, the amplitudes and phases of scattered SPPs can be obtained from the plasmonic interferometric imaging based on a complex analysis algorithm for image reconstruction [11], and people acquired the diameter and refractive index of nanoparticles via retrieving the phase shift of SPP scattering from the image intensity distribution [12].…”

Section: Introductionmentioning

confidence: 99%

Influence of Refractive Index to Plasmonic Interferometric Imaging

et al. 2021

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Plasmonic interferometric imaging has been widely used for fast and label-free detection to nano-objects, which associates the interference between launched and scattered surface plasmon polaritons (SPPs). As scattering of SPPs is affected by the characteristics of nano-objects, particle size, particle index and particle-interface distances have been retrieved from the imaging. Refractive index of dielectric, which tailors the resonant wavelength of launched SPPs, is also a key issue to plasmonic interferometric imaging. Yet, the influence of refractive index to plasmonic interferometric imaging has not been investigated. In this work, we connected the dielectric refractive index to the interferometric image intensity distribution, and found that both fringe periodicities and intensity profiles along SPP wavefronts were tailored by the refractive index, which is illustrated by using glucose solutions with different concentrations. Our research illustrates the pattern change of plasmonic interferometric imaging induced by dielectric refractive index, which not only paves the way for the basic understanding on the plasmonic interferometric imaging, but also provides a new potential visual method for real-time refractive index sensing and monitoring, which will be applied to food safety and environment monitoring.

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“…Benefitting from the SPPs' localized enhancement in subwavelength scale, SPP microscopy has been used to achieve real-time, high sensitivity, label-free detection to single nanoparticles [4]. Single nanoparticles induce the localized enhancement of SPPs, and transforms to far field via leakage radiation for fast and label-free detection [5,6]. This method has been widely applied to chemistry and biology, such as bidirectional electron transfers visualizing [7], local activation energy barrier measuring [8], thermal hysteresis imaging of single spin-crossover nanoparticles [9], and single liposomes and virus detection [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…People had used SPP standing waves as structured illumination to excite fluorophores [16][17][18], and achieved the higher sensitivity by detecting the fluorescent beads. Different from the SPP standing waves interacting with the fluorescent beads, the sensitivity of label-free detection to single nanoparticles is determined by evaluating the localized enhancement [4,6]. By using the SPP standing waves to obtain stronger localized enhancement, the detection sensitivity could be improved.…”

Section: Introductionmentioning

confidence: 99%

The Localized Enhancement of Surface Plasmon Standing Waves Interacting with Single Nanoparticles

et al. 2021

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Real-time, high-sensitivity, and label-free detection to single nanoparticles has been achieved via visualizing the interaction between surface plasmon polaritons (SPPs) and nanoparticles, which is widely applied to chemistry and biology. In this work, aiming to enhance the detection sensitivity to nanoparticles, we explore the interaction of SPP standing waves with single nanoparticles. Compared with SPPs, the inhomogeneous fields of SPP standing waves modulate charge distributions around the particle and excite different electric dipole modes that tailor localized enhancements. For nanoparticles situating at electric antinodes of SPP standing waves, a vertical electric dipole is excited and highdensity charges are stimulated around nanoparticle-film nanocavities, leading to further increased localized enhancement. The localized enhancement experiences more increase with smaller particle size, lower dielectric constant of surrounding medium, and lower particle refractive index. Via tailoring the localized enhancement by SPP standing waves, the sensitivity of SPP microscopy can be improved, which would broaden its applications on nanotechnology, biomedicine, and environmental monitoring.

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Detecting a single nanoparticle by imaging the localized enhancement and interference of surface plasmon polaritons

Cited by 17 publications

References 14 publications

Label-Free Imaging of Single Nanoparticles Using Total Internal Reflection-Based Leakage Radiation Microscopy

Label-Free Imaging of Single Nanoparticles Using Total Internal Reflection-Based Leakage Radiation Microscopy

Influence of Refractive Index to Plasmonic Interferometric Imaging

The Localized Enhancement of Surface Plasmon Standing Waves Interacting with Single Nanoparticles

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