Detecting a rare composite small bowel lymphoma by Magnetic Resonance Imaging coincidentally: A case report with radiological, surgical and histopathological features

Pezzella, Modestino; Brogna, Barbara; Romano, Alessandra; Torelli, Francesco; Esposito, Gennaro; Petrillo, Mario; Romano, Francesco; Martino, Natale Di; Reginelli, Alfonso; Grassi, Roberto

doi:10.1016/j.ijscr.2018.04.005

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…A total of 76 cHL/follicular composite lymphomas from 20 articles were analyzed [ 3 , 6 , 10 , 11 , 12 , 14 , 15 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ].…”

Section: Resultsmentioning

confidence: 99%

Plasticity in Classical Hodgkin Composite Lymphomas: A Systematic Review

Trécourt

Donzel

Fontaine

et al. 2022

Cancers

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The co-occurrence of several lymphomas in a patient defines composite/synchronous lymphoma. A common cellular origin has been reported for both contingents of such entities. In the present review, we aimed to gather the available data on composite lymphomas associating a classical Hodgkin lymphoma (cHL) with another lymphoma, to better understand the plasticity of mature B and T-cells. This review highlights that >70% of patients with a composite lymphoma are ≥55 years old, with a male predominance. The most reported associations are cHL with follicular lymphoma or diffuse large B-cell lymphoma, with over 130 cases reported. The cHL contingent is often of mixed cellularity type, with a more frequent focal/weak CD20 expression (30% to 55.6%) compared to de novo cHL, suggesting a particular pathophysiology. Moreover, Hodgkin cells may express specific markers of the associated lymphoma (e.g., BCL2/BCL6 for follicular lymphoma and Cyclin D1 for mantle cell lymphoma), sometimes combined with common BCL2/BCL6 or CCND1 rearrangements, respectively. In addition, both contingents may share similar IgH/IgK rearrangements and identical pathogenic variants, reinforcing the hypothesis of a common clonal origin. Finally, cHL appears to be endowed with a greater plasticity than previously thought, supporting a common clonal origin and a transdifferentiation process during lymphomagenesis of composite lymphomas.

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“…A total of 76 cHL/follicular composite lymphomas from 20 articles were analyzed [ 3 , 6 , 10 , 11 , 12 , 14 , 15 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ].…”

Section: Resultsmentioning

confidence: 99%