Detectability comparison of simulated tumors in digital breast tomosynthesis using high-energy X-ray inline phase sensitive and commercial imaging systems

Ghani, Muhammad U.; Wong, Molly D.; Omoumi, Farid H.; Fajardo, Laurie L.; Yan, Aimin; Wu, Xizeng; Liu, Hong

doi:10.1016/j.ejmp.2018.02.012

Cited by 10 publications

(5 citation statements)

References 44 publications

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“…Our long-term aim is the development of physical breast phantoms dedicated to studying x-ray imaging of the breast, including advanced techniques such as breast CT, phase-contrast and dual-energy imaging. These techniques are implemented at higher photon energies compared to the mammography x-ray imaging (Bisogni et al 2007, Lindfors et al 2008, Zhao et al 2012, Sarno et al 2016, Ghani et al 2017, 2018. To successfully design and manufacture such phantoms the properties of the available printing materials need to be investigated.…”

Section: Introductionmentioning

confidence: 99%

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Suitability of low density materials for 3D printing of physical breast phantoms

et al. 2018

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Breast physical phantoms are a basic tool for the assessment and verification of performance standards in daily clinical practice of x-ray breast imaging modalities. They are also invaluable in testing and evaluation of new x-ray breast modalities to be potentially established, e.g. breast computed tomography, dual-energy breast CT and phase-contrast mammography and tomography. Nowadays, there is a lack or there are only a limited number of breast physical phantoms available for this purpose.The aim of this study is to explore a range of 3D printing materials such as resins, PLA, ABS, Nylon etc, to determine their attenuation and refractive properties, and to finally compare them to the properties of the breast tissues: adipose, glandular and skin.To achieve this goal, step-wedge phantoms were computationally modeled and then manufactured using stereolithographic and fused-deposition modeling technologies. X-ray images of the phantoms were acquired, using monochromatic beam at ID17, ESRF, Grenoble for three energies-30 keV, 45 keV and 60 keV. Experimental data were further processed to obtain the linear attenuation coefficients of these materials. Comparison with theoretical data for the linear attenuation coefficients and the refractive indexes for breast tissues was performed.From the studied materials, most of the resins, Nylon, Hybrid, PET-G show absorption properties close to the glandular tissue, while ABS shows absorption characteristics close to these of the adipose tissue. For phase-contrast imaging, it turns out that the ABS combined with resin-based materials to represent the adipose and glandular tissues, respectively may be a good combination for manufacturing of a phantom suitable for these studies.These results can be used for the design and the construction of a new physical anthropomorphic phantom of the breast with improved anatomical and radiological characteristics dedicated for advanced mammography imaging techniques implemented at higher photon energies.

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Section: Introductionmentioning

confidence: 99%

“…These techniques are implemented at higher photon energies compared to the mammography x-ray imaging (Bisogni et al 2007, Lindfors et al 2008, Zhao et al 2012, Sarno et al 2016, Ghani et al 2017, 2018. To successfully design and manufacture such phantoms the properties of the available printing materials need to be investigated.…”

Section: Danail Ivanovmentioning

confidence: 99%

Suitability of low density materials for 3D printing of physical breast phantoms

et al. 2018

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“…Phase-contrast imaging has shown its value in the preclinical imaging studies, and there has been a rapid acceleration over the past few years towards its clinical implementation [7,9,[42][43][44][45]. Experimentally, the in-line phase sensitive imaging is the most straightforward technique to implement.…”

Section: Discussionmentioning

confidence: 99%

Impact of a single distance phase retrieval algorithm on spatial resolution in X-ray inline phase sensitive imaging

Ghani

Gregory

Omoumi

et al. 2019

BSI

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A single-projection based phase retrieval method based on the phase attenuation duality principle (PAD) was used to compare the spatial resolution of the acquired phase sensitive and PAD processed phase retrieved images. An inline phase sensitive prototype was used to acquire the phase sensitive images. The prototype incorporates a micro-focus x-ray source and a flat panel detector with a 50 μm pixel pitch. A phantom composed of a 2 cm thick 50-50 adipose-glandular mimicking slab sandwiched with a 0.82 cm thick slanted PMMA sharp edge was used. Phase sensitive image of the phantom was acquired at 120 kV, 3.35 mAs with a 16 μm tube focal spot size under a geometric magnification (M) of 2.5. The PAD based method was applied to the acquired phase sensitive image for the retrieval of phase values. With necessary data processing, modulation transfer function (MTF) curves were determined for the estimation and comparison of the spatial resolution. The PAD processed phase retrieved values of the phantom were in good agreement with the theoretically calculated values. Phase sensitive images showed higher spatial resolution at all spatial frequencies compared to the phase retrieved images. It was noted that the highfrequency signal components in the retrieved image were suppressed that resulted in lower MTF values. When compared to the phase sensitive image, the cutoff resolution (10% MTF) for phase retrieved image dropped 32% from 15.6 lp/mm (32 μm) to 10.6 lp/mm (47 μm). The resolution offered by this phase sensitive prototype is radiographically enough to detect breast cancer.

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“…[24][25][26] The PAD-based method has been applied in various studies to generate and evaluate phase sensitive images. [27][28][29][30][31][32][33] The details of the PAD-based retrieval method can be found in the supplementary information (SI).…”

Section: Introductionmentioning

confidence: 99%

“…One of the single distance phase retrieval methods which is based on the phase attenuation duality principle (PAD), is well suited for clinical imaging 24–26 . The PAD‐based method has been applied in various studies to generate and evaluate phase sensitive images 27–33 . The details of the PAD‐based retrieval method can be found in the (SI).…”

Section: Introductionmentioning

confidence: 99%

Development and preclinical evaluation of a patient‐specific high energy x‐ray phase sensitive breast tomosynthesis system

Ghani

Fajardo

et al. 2021

Medical Physics

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Background: This article reports the first x-ray phase sensitive breast tomosynthesis (PBT) system that is aimed for direct translation to clinical practice for the diagnosis of breast cancer. Purpose: To report the preclinical evaluation and comparison of the newly built PBT system with a conventional digital breast tomosynthesis (DBT) system. Methods and materials: The PBT system is developed based on a comprehensive inline phase contrast theoretical model. The system consists of a polyenergetic microfocus x-ray source and a flat panel detector mounted on an arm that is attached to a rotating gantry. It acquires nine projections over a 15°angular span in a stop-and-shoot manner. A dedicated phase retrieval algorithm is integrated with a filtered back-projection method that reconstructs tomographic slices. The American College of Radiology (ACR) accreditation phantom, a contrast detail (CD) phantom and mastectomy tissue samples were imaged at the same glandular dose levels by both the PBT and a standard of care DBT system for image quality characterizations and comparisons. Results: The PBT imaging scores with the ACR phantom are in good to excellent range and meet the quality assurance criteria set by the Mammography Quality Standard Act. The CD phantom image comparison and associated statistical analyses from two-alternative forced-choice reader studies confirm the improvement offered by the PBT system in terms of contrast resolution, spatial resolution, and conspicuity. The artifact spread function (ASF) analyses revealed a sizable lateral spread of metal artifacts in PBT slices as compared to DBT slices. Signal-to-noise ratio values for various inserts of the ACR and CD phantoms further validated the superiority of the PBT system. Mastectomy sample images acquired by the PBT system showed a superior depiction of microcalcifications vs the DBT system. Conclusion:The PBT imaging technology can be clinically employed for improving the accuracy of breast cancer screening and diagnosis.

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Detectability comparison of simulated tumors in digital breast tomosynthesis using high-energy X-ray inline phase sensitive and commercial imaging systems

Cited by 10 publications

References 44 publications

Suitability of low density materials for 3D printing of physical breast phantoms

Suitability of low density materials for 3D printing of physical breast phantoms

Impact of a single distance phase retrieval algorithm on spatial resolution in X-ray inline phase sensitive imaging

Development and preclinical evaluation of a patient‐specific high energy x‐ray phase sensitive breast tomosynthesis system

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