Detección viral y respuesta serológica en pacientes críticos intubados con SARS-CoV-2. Implicaciones para retirada de aislamiento

Garmendia, J.L. García; Arcos, M Ramírez; Almodóvar, Agustín; Caballero, M Chávez; Amigo, V. Jorge; Martino, Mariangela

doi:10.1016/j.medin.2020.04.014

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…La respuesta inflamatoria sigue siendo la piedra angular en esta patología por el hecho que desencadena una serie de eventos en cascada que culminan con la liberación de citocinas y quimiocinas, resultado de la replicación viral aumentada y la destrucción celular. Esta serie de eventos crea un círculo vicioso de tormentas y agravamiento por citocinas (García Garmendia et al, 2020).…”

Section: Contenidounclassified

Marcadores inflamatorios y severidad del COVID-19

Sagastume

2022

Rev. Div. Cien.

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OBJETIVO: fundamentar la asociación de marcadores inflamatorios con la severidad del COVID-19. METODOLOGÍA: se realizó una revisión precisa y coherente de bibliografías sustentadas en fuentes primarias y secundarias que incluyeron información actualizada. RESULTADOS: los marcadores inflamatorios ocupan un papel importante en el desarrollo y progresión de la enfermedad por COVID-19. El análisis de los biomarcadores en los pacientes contagiados permite predecir qué pacientes pueden llegar a evolucionar a un cuadro severo de la enfermedad. Los marcadores inflamatorios que más se han visto correlacionados con severidad por COVID-19 han sido IL-6 y PCR. Otros como la ferritina a pesar de que tienen alto valor predictivo varía mucho en consideración con ciertas patologías. La PCT, VSG y SAA no tienen mayor injerencia sobre la severidad de la enfermedad. CONCLUSIÓN: los niveles séricos elevados de IL-6>32,1 pg/ml y PCR >41,8 mg/L al ingreso, mostraban correlación con COVID-19 severo, además, ambos pueden usarse también de forma efectiva para predecir mortalidad. El resto de los marcadores aún tiene una aplicación controversial.

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Section: Contenidounclassified

Marcadores inflamatorios y severidad del COVID-19

Sagastume

2022

Rev. Div. Cien.

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“…Mavroulis et al [6] used the same methodology to investigate post-disaster trends and factors affecting the evolution of the COVID-19 pandemic in areas affected by geological and hydrometeorological hazards in Greece. In particular, it was taken into account that the estimated incubation period of SARS-CoV-2 ranges from 2 to 14 days (median incubation time: 5 days) [23,24] and that SARS-CoV-2 can be detected by the polymerase chain reaction (PCR) test in infected patients up to 21 days after the onset of symptoms [25,26]. As a result, COVID-19 cases reported 5 days after disasters could be attributed to disaster-related adverse effects.…”

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confidence: 99%

Multi-Hazard Emergency Response for Geological Hazards Amid the Evolving COVID-19 Pandemic: Good Practices and Lessons Learned from Earthquake Disaster Management in Greece

et al. 2022

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Since the beginning of 2020, the COVID-19 pandemic has caused unprecedented global disruption with considerable impact on human activities. However, natural hazards and related disasters do not wait for SARS-CoV-2 to vanish, resulting in the emergence of many conflicting issues between earthquake emergency response actions and pandemic mitigation measures. In this study, these conflicting issues are highlighted through the cases of four earthquakes that struck Greece at different phases of the pandemic. The earthquake effects on the local population and on the natural environment and building stock form ideal conditions for local COVID-19 outbreaks in earthquake-affected communities. However, the implementation of response actions and mitigation measures in light of a multi-hazard approach to disaster risk reduction and disaster risk management has led not only to the maintenance of pre-existing low viral load in the earthquake-affected areas, but in some cases even to their reduction. This fact suggests that the applied measures are good practice and an important lesson for improving disaster management in the future. Taking into account the aforementioned, a series of actions are proposed for the effective management of the impact of a geological hazard in the midst of an evolving biological hazard with epidemiological characteristics similar to the COVID-19 pandemic.

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