Detección de diabetes tipo LADA en pacientes diabéticos con exceso ponderal. ¿Es adecuado el tratamiento con metformina?

Abstract

The percentage of type-1 LADA in our sample made us wonder whether we should search for pancreatic antibodies more often in primary care. More studies on the prevalence of type-1 LADA in our country are needed, especially in diabetic patients with overweight. Type-1 LADA patients improved their metabolic control after metformin treatment and showed a drastic decrease in insulin levels. Further studies are needed to evaluate whether metformin improves metabolic control, even though it may not protect insulin reserves, and to contrast metformin with other drugs.

Latent Autoimmune Diabetes in Adults

“…Treatment with metformin has no direct action on the β cell, and it could be indicated in patients with LADA with clinical characteristics of metabolic syndrome or with obesity. This treatment allowed a good control of HbA1c and caused a drastic decrease in insulinemia [69].…”