Detecção de Epstein-Barr vírus no carcinoma da nasofaringe: implicações numa área de baixo risco

Breda, Eduardo; Catarino, Raquel; Azevedo, Isabel; Lobão, Marisa; Monteiro, Eurico; Medeiros, Rui

doi:10.1590/s1808-86942010000300007

Cited by 25 publications

(6 citation statements)

References 12 publications

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“…For EBV detection nested-PCR method was used by primers that used in Breda et al study [34], including 5′-GCGGGTG-GAGGGAAAGG-3′ and 5′-GTCAGC CAAGGGACGCG-3′ for the first PCR round as well as 5′-GCCACCTGGCAGCCCTAAAG-3′ and 5′-AGGC TGCCCACCCTGAGGAT-3′ for the second PCR round [34]. Ten nM of each primer (Metabion, Germany), 2X Taq Master Mix, 1 μg of template DNA, and water at a final volume of 25 μl.…”

Section: Detection Of Hpv and Ebv By Pcrmentioning

confidence: 99%

Possible role of HPV/EBV coinfection in anoikis resistance and development in prostate cancer

et al. 2021

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Background This study aimed to evaluate the possible role of human papillomavirus (HPV) and Epstein–Barr virus (EBV) coinfection as an etiological factor for prostate cancer (PCa) development. Methods This case-control study was conducted on 67 patients with PCa and 40 control subjects. The expression levels of cellular and viral factors involved in inflammation, tumor progression, and metastasis were quantified, using the enzyme-linked immunosorbent assay (ELISA) and quantitative real-time polymerase chain reaction (qRT-PCR) assay. Results The EBV/HPV coinfection was reported in 14.9% of patients in the case group and 7.5% of the control subjects. The high-risk types of HPV, that is, HPV 16 and HPV 18, were responsible for 50 and 30% of HPV/EBV-coinfected PCa cases (n = 10), respectively. No significant relationship was observed between PCa and HPV/EBV coinfection (OR = 2.9, 95% CI: 0.18–45.2, P = 0.31). However, the highest percentage of HPV genome integration was found in the HPV/EBV-coinfected PCa group (8/10; 80%). Also, the mean expression levels of inflammatory factors (IL-17, IL-6, TNF-α, NF-κB, VEGF, ROS, and RNS), anti-apoptotic mediators (Bcl-2 and survivin), and anti-anoikis factors (Twist and N-cadherin) were significantly higher in the HPV/EBV-coinfected PCa group, compared to the non-coinfected PCa cases. Nevertheless, the tumor-suppressor proteins (p53 and pRb) and E-cadherin (inhibitor of anoikis resistance) showed significant downregulations in the HPV/EBV-coinfected PCa group, compared to the non-coinfected PCa cases. Conclusion The HPV/EBV coinfection may be an etiological factor for PCa through modulation of cellular behaviors.

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Section: Detection Of Hpv and Ebv By Pcrmentioning

confidence: 99%

Possible role of HPV/EBV coinfection in anoikis resistance and development in prostate cancer

et al. 2021

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“…Nevertheless, direct oncoviruses, such as EBV, HPV or KSHV, have also been linked with inflammatory immune responses. In the case of EBV, the viral protein LMP-1 activates signaling via the PI3K/Akt, the JAK/STAT and the NFκB pathway induces cancer cell hallmarks and, in that regard, tumor-promoting inflammation [96][97][98]. Furthermore, EBERs, viral RNA transcripts, activate the IL6/STAT3 pathway and induce IL6, IL9, IL10 and IGF-1, which promote inflammation and growth [99,100].…”

Section: Oncovirus Induced Inflammationmentioning

confidence: 99%

Cancer Patients Have a Higher Risk Regarding COVID-19–and Vice Versa?

2020

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The world is currently suffering from a pandemic which has claimed the lives of over 230,000 people to date. The responsible virus is called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and causes the coronavirus disease 2019 (COVID-19), which is mainly characterized by fever, cough and shortness of breath. In severe cases, the disease can lead to respiratory distress syndrome and septic shock, which are mostly fatal for the patient. The severity of disease progression was hypothesized to be related to an overshooting immune response and was correlated with age and comorbidities, including cancer. A lot of research has lately been focused on the pathogenesis and acute consequences of COVID-19. However, the possibility of long-term consequences caused by viral infections which has been shown for other viruses are not to be neglected. In this regard, this opinion discusses the interplay of SARS-CoV-2 infection and cancer with special focus on the inflammatory immune response and tissue damage caused by infection. We summarize the available literature on COVID-19 suggesting an increased risk for severe disease progression in cancer patients, and we discuss the possibility that SARS-CoV-2 could contribute to cancer development. We offer lines of thought to provide ideas for urgently needed studies on the potential long-term effects of SARS-CoV-2 infection.

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“…Similar results were obtained in a number of studies done on patients of NPC especially from non-endemic regions. (22)(23)(24)(25)(26)(27) Sino-nasal carcinomas are neoplasms arising in the nasal cavity and paranasal sinuses. (28) Sinonasal carcinomas are strongly associated with EBV in Chinese patients but not in western patients.…”

Section: Observation and Resultsmentioning

confidence: 99%

Association of Epstein Barr Virus With Mucosal Squamous Cell Cancers of Head and Neck

Zaffar¹,

Afroz²,

Rashid³

et al. 2015

jemds

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Detecção de Epstein-Barr vírus no carcinoma da nasofaringe: implicações numa área de baixo risco

Cited by 25 publications

References 12 publications

Possible role of HPV/EBV coinfection in anoikis resistance and development in prostate cancer

Possible role of HPV/EBV coinfection in anoikis resistance and development in prostate cancer

Cancer Patients Have a Higher Risk Regarding COVID-19–and Vice Versa?

Association of Epstein Barr Virus With Mucosal Squamous Cell Cancers of Head and Neck

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