Detailed review and analysis of complex radiotherapy clinical trial planning data: Evaluation and initial experience with the SWAN software system

Ebert, Martin A.; Haworth, Annette; Kearvell, Rachel; Hooton, B.W.; Coleman, Rhonda; Spry, Nigel; Bydder, Sean; Joseph, David

doi:10.1016/j.radonc.2007.11.013

Cited by 68 publications

(53 citation statements)

References 30 publications

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“…The digital radiotherapy treatment plan for every patient, incorporating CT images, delineated anatomical structures, treatment plan parameters and 3-dimensional dose matrix, was independently reviewed using the SWAN [19] and archived. Delineation of the bladder was not mandatory for RADAR, thus, all plans were manually reviewed and bladder outlining either verified or manually added.…”

Section: Principal Components Of Bladder Dose-surface Histogrammentioning

confidence: 99%

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Yahya

Ebert

Bulsara

et al. 2015

Radiotherapy and Oncology

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Urinary symptoms (frequency, incontinence, dysuria and haematuria) were prospectively assessed using LENT-SOMA to a median of 72 months. The endpoints assessed were prevalence (grade≥1) at the end of radiotherapy (representing acute symptoms), at 18-, 36-and 54-month follow-ups (representing late symptoms) and peak late incidence including only grade≥2. Impact of factors were assessed using multivariate logistic regression models with correction for over-optimism. Results: Baseline symptoms, non-insulin dependent diabetes mellitus, age and PC1 (correlated to the mean dose) impact symptoms at >1 timepoints. Associations at a single timepoint were found for cerebrovascular condition, ECOG status and non-steroidal anti-inflammatory drug intake. Peak incidence analysis shows the impact of baseline, bowel and cerebrovascular condition and smoking status. Conclusions:The prevalence and incidence analysis provide a complementary view for urinary symptom prediction. Sustained impacts across time points were found for several factors while some associations were not repeated at different time points suggesting poorer or transient impact.4

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Section: Principal Components Of Bladder Dose-surface Histogrammentioning

confidence: 99%

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Yahya

Ebert

Bulsara

et al. 2015

Radiotherapy and Oncology

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“…Different approaches have been adopted to address the issue of prospective ICR. 14,15,[17][18][19] The European Organisation for Research and Treatment of Cancer have reported the development of a digital central review facility, where centres upload data through a secure website and then the reviewers, who may not be based at the central RTQA centre, are able to remotely access the data through a terminal server. 20 The International Society of Paediatric Oncology (Europe) high-risk neuroblastoma group have developed a web-based platform which allows remote uploading of radiology and RT-related data and images from the participating centres, allowing remote review by clinicians in a timely fashion, without the need to meet in one place at one time.…”

Section: Discussionmentioning

confidence: 99%

“…Study chairs wishing to perform retrospective reviews have a secure virtual private network connection to the database and can access the information (T Fitzgerald, Quality Assurance Review Centre, University of Massachusets, personal communication). SWAN 17 was developed in Australia with the aim of facilitating objective analysis, QA and review of digital treatment planning data from Trans Tasman Radiation Oncology Group multicentre RT trials. It is utilized for central review, pre-accrual benchmark cases and credentialing.…”

Section: Discussionmentioning

confidence: 99%

Prospective review of radiotherapy trials through implementation of standardized multicentre workflow and IT infrastructure

Gwynne¹,

Jones

Maggs

et al. 2016

BJR

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“…A software system developed at the SCGH, known as 'SWAN', was made available for the analysis of exported treatment plans and Digital Imaging and Communication in Medicine (DICOM) portal images. 47 …”

Section: Data Collectionmentioning

confidence: 99%

Comprehensive Australasian multicentre dosimetric intercomparison: Issues, logistics and recommendations

et al. 2009

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Summary The present paper describes the logistics of the 2004–2008 Australasian Level III Dosimetry Intercomparison. Dosimetric intercomparisons (or ‘audits’) can be used in radiotherapy to evaluate the accuracy and quality of radiation delivery. An intercomparison was undertaken in New Zealand and Australia to evaluate the feasibility and logistics of ongoing dosimetric intercomparisons that evaluate all steps in the radiotherapy treatment process, known as a ‘Level III’ intercomparison. The study commenced in 2002 with the establishment of a study team, definition of the study protocol, acquisition of appropriate equipment and recruitment of participating radiotherapy centres. Measurements were undertaken between October 2004 and March 2008, and included collation of data on time, costs and logistics of the study. Forty independent Australian and New Zealand radiotherapy centres agreed to participate. Measurement visits were made to 37 of these centres. Data is presented on the costs of the study and the level of support required. The study involved the participation of 16 staff at the study centre who invested over 4000 hours in the study, and of over 200 professionals at participating centres. Recommendations are provided for future phantom‐based intercomparisons. It is hoped that the present paper will be of benefit to any centres or groups contemplating similar activities by identifying the processes involved in establishing the study, the potential hazards and pitfalls, and expected resource requirements.

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Detailed review and analysis of complex radiotherapy clinical trial planning data: Evaluation and initial experience with the SWAN software system

Cited by 68 publications

References 30 publications

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

Prospective review of radiotherapy trials through implementation of standardized multicentre workflow and IT infrastructure

Comprehensive Australasian multicentre dosimetric intercomparison: Issues, logistics and recommendations

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