Detailed phytochemical characterization and bioactive properties of Myrtus nivelii Batt & Trab

Abstract

The endemic Algerian myrtle, Myrtus nivelii Batt & Trab., was evaluated for its bioactive properties, such as antioxidant, anti-inflammatory, cytotoxic and antibacterial activities, and correlated with the individual phenolic compounds identified in its crude aqueous extract and subsequent organic fractions (ethyl acetate and butanol). Flavonols, such as myricetin, kaempferol and quercetin glycoside derivatives, were the major phenolic compounds found, along with the presence of ellagitannins. The ethyl acetate fraction contained the highest amount of phenolic compounds, followed by the butanol fraction and, finally, the crude aqueous extract. In general, all samples exhibited an excellent bioactivity, namely the ethyl acetate fraction that presented strong antioxidant activity, when compared to the standard trolox, strong cytotoxicity and antibacterial activity, especially against MRSA and MSSA. The present study revealed that the ethyl acetate fraction of M. nivelii could be used as a source of bioactive compounds in the food and pharmaceutical industries.

Phytochemical analysis and assessment of antioxidant, antimicrobial, anti-inflammatory and cytotoxic properties of Tetraclinis articulata (Vahl) Masters leaves

“…Moreover, flavonol rhamnosides have also been known to display a remarkable cytotoxic activity, inhibiting the proliferation of cultured human tumor cell lines, A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (skin), XF498 (central nerve system) and (Kim et al, 2004). The variation in flavonoids content and composition between the crude aqueous extract and its fractions could explain the differences observed in the cytotoxicity results, which is in agreement with other studies (Chaudhary et al, 2015;Rached et al, 2017Rached et al, , 2016. To the author's best knowledge, there are no previous reports on the cytotoxic effects of the studied plant.…”

Antioxidant Activity of Myrtus communis L. and Myrtus nivellei Batt. & Trab. Extracts: A Brief Review

“…The chemical composition of Saharan myrtle only very recently was unravelled [ 20 , 22 ]. The biological properties of these extracts and their compounds were also reported [ 20 ].…”

“…The chemical composition of crude aqueous extract, ethyl acetate and butanol fractions of Saharan myrtle leaves conducted by liquid chromatography with diode array detection, coupled to mass spectrometry (ion trap) with electrospray ionization (HPLC-DAD−ESI/MS n ) permitted to identify 17, 25, and 19 compounds, respectively ( Table 4 ) [ 22 ]. The ethyl acetate fraction had the highest concentration of phenol compounds, followed by the butanol fraction and the crude aqueous extract.…”

“…The chemical composition of Saharan myrtle is less studied than that of myrtle. The main constituents reported include volatile essential oils [ 16 , 21 ], phenols (flavonoids, anthocyanins, and tannins), norterpenoids [ 19 , 20 , 21 , 22 ].…”

Profiling polyphenol composition by HPLC-DAD-ESI/MSn and the antibacterial activity of infusion preparations obtained from four medicinal plants

“…flavonoids, phenolic acids and others). 7,[9][10][11] Antibiotic resistance is a serious and growing phenomenon in contemporary medicine and has emerged as one of the preeminent public health concerns in the 21st century. 4,12 Most pathogenic bacteria have developed resistance to modern antibiotics, as a result of which we are observing multi-drug resistance among bacterial strains.…”