Detailed deletion mapping of chromosome 9p21–22 in nasopharyngeal carcinoma

Expression and functional characterization of LRRC4, a novel brain‐specific member of the LRR superfamily

“…Loss of heterozygosity (LOH) of markers on human chromosome 7q are frequently encountered in malignant myeloid disorders as well as in head and neck, breast, prostate, ovarian, colon, gastric, pancreatic, and renal cell carcinomas [1,2]. Our previous studies demonstrate there is the LOH on chromosome 7q31-ter in nasopharyngeal carcinoma [3,4]. Introduction of an intact copy of human chromosome 7 restored senescence of immortalized human fibroblast cell lines harboring LOH of markers within 7q31-32 and inhibited the tumorigenic phenotype of a murine squamous cell carcinoma cell line [5].…”

Analysis of gene expression identifies candidate molecular markers in nasopharyngeal carcinoma using microdissection and cDNA microarray

“…There is a large body of evidence implicating the intake of salted food, EBV infection and the function of genetic factors, as a major cause of the high incidence of NPC in these geographical regions (Hildesheim and Levine 1993;Lo et al 2004). LOH studies unveiled that there are frequent allelic losses on chromosomes 3p, 9p, 11q, 13q, and 14q (Deng et al 1998;Yang et al 1999;Huang et al 1994;Hui et al 1996;Mutirangura et al 1998Mutirangura et al , 1999. Chromosome 3p21 has also been identiWed as a functional NPC susceptibility locus by the linkage analysis of Chinese pedigrees (Xiong et al 2004).…”

Isolation and characterization of a novel cDNA, UBAP1, derived from the tumor suppressor locus in human chromosome 9p21-22

“…As a step toward isolation of the putative tumor suppressor gene(s), we earlier delineated a novel minimal LOH region between marker D9S161-D9S1853 at 9p21±22 using 11 high-density microsatellite polymorphic DNA probes and 25 primary NPC materials. We subsequently screened the expression patterns of 25 novel ESTs in NPC cell line HNE1, primary culture nasopharyngeal epithelial cells and biopsies using dierential RT-PCR to identify novel genes in this region (Yang et al 1999). One of these ESTs (GenBank entry: w56112) was found down-regulated in NPC.…”