A correlation between Computed Tomography (CT) number, matrix porosity, and permeability is presented that enables the petrophysical characterization of highly heterogeneous reservoir rocks with a level of detail that is not achievable by direct laboratory measurements. A total of 143 ft. of 4 in. diameter reservoir core from the North Burbank Unit (NBU) in Oklahoma were imaged using a state of the art medical computed tomography scanner. The CT number, which is a function of the density and composition of the rock was observed to correlate with both porosity and permeability values that were measured discretely along the core using conventional laboratory techniques. A mathematical expression was fit to the data that allows the prediction of the porosity and the permeability of the core within the 350 m isotropic resolution that the CT scanning unit is capable of.We also show that in the case of reservoirs with high vertical heterogeneity, where permeability variations of hundreds of millidarcies occur within one foot, the selection by visual inspection of core plugs for laboratory measurement of petrophysical properties leads to a flawed characterization of the stratigraphic column as some of the plugs are taken along bedding planes, and therefore are comprised of more than one rock type. We propose the use of CT-scan imaging to identify different rock types and take core plugs that are representative of unique rock types as a better practice for rock characterization.Our work has greatly improved the knowledge of the stratigraphic column of the NBU and has provided a better understanding of the degree of vertical heterogeneity in the area. The detailed knowledge of permeability and porosity obtained from the CT numbers of the cored well can be used for the adjustment of petrophysical models based on well logs to enable the extrapolation of the detailed petrophysical characterization of the cored well to other NBU wells that have not been cored but have log data. The implementation of the proposed technique will help optimize well completion, sand perforation, water and gas shut off treatments, and EOR schemes implementation among other activities.