Detailed behaviour of endothelial wall shear stress across coronary lesions from non-invasive imaging with coronary computed tomography angiography

Hoogen, Inge J. van den; Schultz, Jussi; Kuneman, Jurriën H.; Graaf, Michiel A. de; Kamperidis, Vasileios; Broersen, Alexander; Jukema, J Wouter; Sakellarios, Antonis I.; Nikopoulos, Sotirios; Kyriakidis, Savvas; Naka, Katerina K.; Michalis, Lampros K.; Fotiadis, Dimitrios I.; Maaniitty, Teemu; Saraste, Antti; Bax, Jeroen J.; Knuuti, Juhani

doi:10.1093/ehjci/jeac095

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…[11][12][13]. In contrast to invasive imaging methods, non-invasive imaging techniques for atherosclerotic plaque detection with undoubted advantages, such as noninvasiveness, precision, high spatiotemporal resolution, and low toxicity, have taken a chief place [14,15]. So far, the main non-invasive imaging approaches for patients include ultrasound, X-ray, CT, and magnetic resonance imaging (MRI), having different uses [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Engineering molecular nanoprobes to target early atherosclerosis: Precise diagnostic tools and promising therapeutic carriers

Zan¹,

An²,

Wu³

et al. 2023

Nanotheranostics

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Atherosclerosis, an inflammation-driven chronic blood vessel disease, is a major contributor to devastating cardiovascular events, bringing serious social and economic burdens. Currently, non-invasive diagnostic and therapeutic techniques in combination with novel nanosized materials as well as established molecular targets are under active investigation to develop integrated molecular imaging approaches, precisely visualizing and/or even effectively reversing early-stage plaques. Besides, mechanistic investigation in the past decades provides many potent candidates extensively involved in the initiation and progression of atherosclerosis. Recent hotly-studied imaging nanoprobes for detecting early plaques mainly including optical nanoprobes, photoacoustic nanoprobes, magnetic resonance nanoprobes, positron emission tomography nanoprobes, and other dual- and multi-modality imaging nanoprobes, have been proven to be surface functionalized with important molecular targets, which occupy tailored physical and biological properties for atherogenesis. Of note, these engineering nanoprobes provide long blood-pool residence and specific molecular targeting, which allows efficient recognition of early-stage atherosclerotic plaques and thereby function as a novel type of precise diagnostic tools as well as potential therapeutic carriers of anti-atherosclerosis drugs. There have been no available nanoprobes applied in the clinics so far, although many newly emerged nanoprobes, as exemplified by aggregation-induced emission nanoprobes and TiO 2 nanoprobes, have been tested for cell lines in vitro and atherogenic animal models in vivo , achieving good experimental effects. Therefore, there is an urgent call to translate these preclinical results for nanoprobes into clinical trials. For this reason, this review aims to give an overview of currently investigated nanoprobes in the context of atherosclerosis, summarize relevant published studies showing applications of different kinds of formulated nanoprobes in early detection and reverse of plaques, discuss recent advances and some limitations thereof, and provide some insights into the development of the new generation of more precise and efficient molecular nanoprobes, with a critical property of specifically targeting early atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

Engineering molecular nanoprobes to target early atherosclerosis: Precise diagnostic tools and promising therapeutic carriers

Zan¹,

An²,

Wu³

et al. 2023

Nanotheranostics

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Innovations in cardiac computed tomography: Imaging in coronary artery disease

Manubolu,

Ichikawa,

Budoff

2024

Progress in Cardiovascular Diseases

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The year 2022 in the European Heart Journal—Cardiovascular Imaging: Part I

Petersen,

Muraru,

Westwood

et al. 2023

European Heart Journal - Cardiovascular Imaging

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The European Heart Journal - Cardiovascular Imaging with its over ten years existence is an established leading multimodality cardiovascular imaging journal. Pertinent publications including original research, how to papers, reviews, consensus documents, in our Journal from 2022 have been highlighted in two reports. Part I focuses on cardiomyopathies, heart failure, valvular heart disease and congenital heart disease and related emerging techniques and technologies.

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Detailed behaviour of endothelial wall shear stress across coronary lesions from non-invasive imaging with coronary computed tomography angiography

Cited by 4 publications

References 34 publications

Engineering molecular nanoprobes to target early atherosclerosis: Precise diagnostic tools and promising therapeutic carriers

Engineering molecular nanoprobes to target early atherosclerosis: Precise diagnostic tools and promising therapeutic carriers

Innovations in cardiac computed tomography: Imaging in coronary artery disease

The year 2022 in the European Heart Journal—Cardiovascular Imaging: Part I

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