Detailed analysis of peripheral blood natural killer cells in women with repeated IVF failure

Sacks, Gavin; Yang, Yizhuo; Smith, Susan L.; Chapman, Michael

doi:10.1016/j.jri.2012.03.280

Cited by 16 publications

(27 citation statements)

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“…Circulating NK cells were found elevated both in terms of percentage and cytotoxicity in patients with RM . Increased number of peripheral NK cells was regarded as important markers for RM and RIF . Peripheral blood NK cell activity was significantly decreased during early pregnancy as compared to the non‐pregnant status .…”

Section: Discussionmentioning

confidence: 98%

Increased Circulating Th1/Th2 Ratios But Not Other Lymphocyte Subsets During Controlled Ovarian Stimulation are Linked to Subsequent Implantation Failure after Transfer of In Vitro Fertilized Embryos

Liang

Yin

Cai

et al. 2014

American J Rep Immunol

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Section: Discussionmentioning

confidence: 98%

Increased Circulating Th1/Th2 Ratios But Not Other Lymphocyte Subsets During Controlled Ovarian Stimulation are Linked to Subsequent Implantation Failure after Transfer of In Vitro Fertilized Embryos

Liang

Yin

Cai

et al. 2014

American J Rep Immunol

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“…The CBT also decreased to a statistically significant degree (p = 0.023) in all the cycles (Table 2). Average DBP mmHg) 73.00 ± 6.251 67.07 ± 6.275 4 71.22 ± 5.139 5,6 Average HR (bpm) 81.81 ± 8.526 68.93 ± 6.989 7 70.96 ± 6.964 8,9 Average CBT (°C) 36.23 ± 0.476 36.50 ± 0.552 10 Source: internal. Note.…”

Section: Resultsmentioning

confidence: 99%

“…Although RPL and RIF are different clinical entities, the literature shows common defining characteristics, in particular alterations associated with the functioning of the immune system [5][6][7][8]. The inflammatory immune response may be altered in women with RPL and/or RIF due to the increase of natural killer cells (NKC) in peripheral blood [5,9,10].…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin Therapy in Infertile Women: Safety and Tolerance

2018

IJWHC

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Some authors consider the positive benefits of IVIG therapy in terms of increment in birth rate in women who had suffered two or more spontaneous abortions [11]. IVIG administration has potential benefits in women with RPL and RIF who present NKC increments [12,13]. Additionally, other papers have explicitly shown that this treatment act as an immuno modulator mechanism which reduces NKC activation and favors embryonic implantation increasing the clinical pregnancy rate in women with RIF [14]. Abstract Introduction and Objectives:According to most recent surveys, infertility rates are very high in Spain. Even so, current therapeutic options for increasing fertility are challenging. Immunological causes of infertility such as an increase in natural killer cells have been studied in recent work, for example by using immunoglobulins. Providing care and support for women during such treatments is the traditional responsibility of nursing professionals. The objective of this study was to understand how patients adapt to treatments with immuno globulins at FIV Valencia i . Methods:Retrospective observational study which monitored 40 intravenous immunoglobulin infusions: 400 mg/kg in 27 cases and 200 mg/kg in 13 cases. The state of women's health was studied with home monitoring, and women's answers about their health statuses were measured using Liker scales with four values. These identified the occurrence of symptoms and the need for analgesic therapy. The data was analyzed using SPSS.Results: Vital sign monitoring reflected values within the normal limits during all 40 infusions; the figures decreased slightly during the infusion but subsequently returned to normal. More women (59.3%) treated with 400 mg/kg intravenous immuno globulins (IVIG) manifested symptoms compared to 38.5% of women treated with 200 mg/kg IVIG (p = 0.185). The only common symptom that appeared was a headache which easily resolved after analgesic therapy. Conclusion:Nurses play a very important role in the implementation of IVIG therapy. These results show that women adhere well to this therapy at FIV Valencia and none of them reported any severe symptoms. Our findings may facilitate the design of future research studies aimed at improving care for infertile women.

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“…Lupus anticoagulant, Kaolin Clotting time and thrombophilias were also tested using commercial assays (Douglass Hanly Moir, Sydney; SA pathology and Clinpath, Adelaide). High levels of peripheral blood natural killer (pbNK) cells were defined as pbNK cells comprising >18% of total lymphocytes with activated cells (CD56 dim CD69 + ) at a concentration >12 × 10 6 / mL (King et al, 2010;Sacks et al, 2012). pbNK cell levels were defined as borderline when only one of the above criteria was met, or if the percentage of pbNK cells was 12-18%.…”

Section: Immune Testingmentioning

confidence: 99%

Intralipid Immunotherapy for Repeated IVF Failure

Ehrlich

Hull

Walkley³

et al. 2019

FandR

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The intravenous fat emulsion, intralipid, has been hypothesised to be an effective and safe treatment for repeated in vitro fertilisation (IVF), implantation failure and pregnancy loss. This exploratory, retrospective cohort study determined pregnancy outcomes and documented adverse events associated with intralipid use. Ninety-three women were identified as having received intralipid for a history of repeated unsuccessful IVF cycles and pre-viable pregnancy loss in two Australian IVF units that independently recruited between October 2014 and July 2016. Pregnancy outcomes and adverse events were recorded in fresh and frozen embryo transfer cycles in which the infusion was administered. The 93 women who received intralipid had a clinical pregnancy rate of 40.0%, compared with 35.0% in 651 age-matched controls undergoing IVF, which was not significantly different. The intralipid group had a livebirth rate of 35.7%. Apart from flushing, which was experienced by one individual, there were no adverse events associated with intralipid use. As a prelude to definitive evidence of benefit, we did not identify a safety concern or reduced pregnancy rates in intralipid users compared to controls. Indeed, these outcomes were better than expected in a poor prognosis group. This data supports an argument for large, randomised controlled trials to determine the benefit of intralipid in the treatment of recurrent implantation failure or miscarriage.

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Detailed analysis of peripheral blood natural killer cells in women with repeated IVF failure

Cited by 16 publications

References 0 publications

Increased Circulating Th1/Th2 Ratios But Not Other Lymphocyte Subsets During Controlled Ovarian Stimulation are Linked to Subsequent Implantation Failure after Transfer of In Vitro Fertilized Embryos

Increased Circulating Th1/Th2 Ratios But Not Other Lymphocyte Subsets During Controlled Ovarian Stimulation are Linked to Subsequent Implantation Failure after Transfer of In Vitro Fertilized Embryos

Immunoglobulin Therapy in Infertile Women: Safety and Tolerance

Intralipid Immunotherapy for Repeated IVF Failure

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