Detachable MOF‐Based Core/Shell Nanoreactor for Cancer Dual‐Starvation Therapy With Reversing Glucose and Glutamine Metabolisms

Du, Hongliang; Meng, Siyu; Geng, Meijuan; Zhao, Pan; Gong, Lunjun; Zheng, Xiaodong; Li, Xiang; Yuan, Zhengqiu; Yang, Hui; Zhao, Yanli; Dai, Liangliang

doi:10.1002/smll.202303253

Cited by 9 publications

(1 citation statement)

References 52 publications

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“…Glutaminase inhibitors, for instance, have been shown to decrease tumor burden. 169 , 170 The use of 6-diazo-5-L-oxo-norleucine (DON) promoted antitumor immunity by greatly favoring OXPHOS over glycolysis in CD8 + T cells while disrupting the metabolism of cancer cells. 171 Notably, DON showed the ability to significantly inhibit the generation and recruitment of MDSCs and to reprogram M2-like TAMs into proinflammatory TAMs, which increased tumor antigen cross-presentation to T cells and enhanced the efficacy of immune checkpoint blockade (ICB).…”

Section: Targeted Dietary Interventions and Mechanistic Insights Into...mentioning

confidence: 99%

Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

Xiao,

Gong,

et al. 2024

Sig Transduct Target Ther

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Diet, serving as a vital source of nutrients, exerts a profound influence on human health and disease progression. Recently, dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases, autoimmune diseases, cardiovascular diseases, and metabolic disorders. These interventions have demonstrated substantial potential in modulating metabolism, disease trajectory, and therapeutic responses. Metabolic reprogramming is a hallmark of malignant progression, and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer eradication. Dietary intake, as a key environmental factor, can influence tumor metabolism. Emerging evidence indicates that dietary interventions might affect the nutrient availability in tumors, thereby increasing the efficacy of cancer treatments. However, the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is complex. Despite encouraging results, the mechanisms underlying diet-based therapeutic strategies remain largely unexplored, often resulting in underutilization in disease management. In this review, we aim to illuminate the potential effects of various dietary interventions, including calorie restriction, fasting-mimicking diet, ketogenic diet, protein restriction diet, high-salt diet, high-fat diet, and high-fiber diet, on cancer and the aforementioned diseases. We explore the multifaceted impacts of these dietary interventions, encompassing their immunomodulatory effects, other biological impacts, and underlying molecular mechanisms. This review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

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Section: Targeted Dietary Interventions and Mechanistic Insights Into...mentioning

confidence: 99%

Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

Xiao,

Gong,

et al. 2024

Sig Transduct Target Ther

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A Nanoreactor Based on Metal–Organic Frameworks With Triple Synergistic Therapy for Hepatocellular Carcinoma

Zheng,

Huang,

et al. 2024

Adv Healthcare Materials

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The transformation of monotherapy into multimodal combined targeted therapy to fully exploit synergistic efficacy is of increasing interest in tumor treatment. In this work, a novel nanodrug‐carrying platform based on iron‐based MOFs, which is loaded with doxorubicin hydrochloride (DOX), dihydroartemisinin (DHA), and glucose oxidase (GOx), and concurrently covalently linked to the photosensitizer 5,10,15,20‐tetrakis(4‐carboxyphenyl)porphyrin (TCPP) in polydopamine (PDA)‐encapsulated MIL‐101(Fe) (denoted as MIL‐101(Fe)‐DOX‐DHA@TCPP/GOx@PDA, MDDTG@P), is successfully developed. Upon entering the tumor microenvironment, MDDTG@P catalyzes the hydrogen peroxide (H2O2) into hydroxyl radicals (·OH) and depletes glutathione (GSH); thus, exerting the role of chemodynamic therapy (CDT). The reduced Fe2+ can also activate DHA, further expanding CDT and promoting tumor cell apoptosis. The introduced GOx will rapidly consume glucose and oxygen (O2) in the tumor; while, replenishing H2O2 for Fenton reaction, starving the cancer cells; and thus, realizing starvation and chemodynamic therapy. In addition, the covalent linkage of TCPP endows MDDTG@P with good photodynamic therapeutic (PDT) properties. Therefore, this study develops a nanocarrier platform for triple synergistic chemodynamic/photodynamic/starvation therapy, which has promising applications in the efficient treatment of tumors.

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Construction of Smartphone‐Integrated Nanozyme Sensor Based on Amino Acid‐Modulated Gold Nanoparticles

Wu,

Li,

et al. 2024

ChemBioChem

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Amino acids are not only the building blocks of proteins but also lead to the development of novel nanomaterials with unique properties. Herein, we proposed a simple strategy to produce gold nanoparticles (Au NPs) with peroxidase‐like (POD‐like) activities by using a series of amino acids as reducing agents, named Au NPs@M (M represents different amino acids). The Au NPs@His was identified as the nanozyme with the most potent catalytic performance, which was used in combination with smartphones to achieve rapid detection of hydrogen peroxide with a detection limit of 0.966 μM. It also enables rapid detection of glucose with a detection limit of 2.904 μM, highlighting the significant contribution of Au NPs@His in expediting the detection of critical biomolecules. This work not only provides a convenient and highly efficient method to identify glucose but also shows the potential of histidine as a reducing agent in constructing Au nanomaterials exerting enzyme‐like catalysis.

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Detachable MOF‐Based Core/Shell Nanoreactor for Cancer Dual‐Starvation Therapy With Reversing Glucose and Glutamine Metabolisms

Cited by 9 publications

References 52 publications

Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

A Nanoreactor Based on Metal–Organic Frameworks With Triple Synergistic Therapy for Hepatocellular Carcinoma

Construction of Smartphone‐Integrated Nanozyme Sensor Based on Amino Acid‐Modulated Gold Nanoparticles

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