Desymmetrization of Cyclohexadienones via [3+2]/[2+1] Domino Annulation: Access to Cyclopropane Fused Tricyclic Enones

Abstract

A [3+2]/[2+1] domino annulation reaction of cyclohexadienones and α‐aryl vinylsulfonium salts has been reported. A range of cyclopropane fused tricyclic enones bearing four contiguous stereocenters were obtained as a single diastereomer in 44‐93% yields. The synthetic utility was demonstrated with the gram‐scale reactions and further transformations of the products.

Correction to “Synthesis of 6/5/3-Fused Tricyclic Scaffolds via Multistep Cascade Cyclization of α-Aryl Vinylsulfoniums with para-Quinamines and para-Quinols”

“…We would like to add a new reference (would be ref 10 in our original work but labeled as ref below) citing the published work of Zhu et al Adv. Synth.…”

“…In conclusion, we have disclosed a straightforward approach to construct hydroindoline-5-one-based 6/5/3-fused polycyclic ring structures through multistep cascade reactions of para -quinamines and α-aryl vinylsulfoniums tetraphenylborate. In the presence of mild conditions, the reactions proceed smoothly to deliver the desired products in generally good yields . This protocol is also applicable to para -quinols to furnish hydrobenzofuran-5-one-based 6/5/3-tricyclic scaffolds.…”