Destructive fat tissue engineering using photodynamic and selective photothermal effects

Inhomogeneity of photo-induced fat cell lipolysis

“…[16][17][18] Various aspects of light on the cells of human adipose tissue are considered in [19][20][21][22][23] . Questions light degradation of adipose tissue, including in combination with selective thermal effect are considered in the papers 8,22,[24][25][26] .…”

Fat tissue histological study at NIR laser treatment of the skin in vivo

“…[24][25][26] ICG tissue staining may induce the photodynamic effect. [16][17][18][19][20][27][28][29] Relatively narrow absorption peak of this dye allow for effective use in selective laser destruction of tissues, but caution should be accounted for because dye molecules at interaction with organic molecules of a tissue change their absorption spectrum peaks up to 10-20 nm. [27][28][29][30] The intensity and position of the absorption bands depend on the ICG solvents used.…”

“…5,[16][17][18][19][20] In particular, it relates to the employment of localized optical (laser) radiation of the appropriate wavelength and power, which also may be integrated in conjunction with localized specific fat tissue staining or lipolytic agent application, to noninvasive and non-or least-destructively downsize fat tissue volume and thereby modify contour/shape local target adipose tissue.…”

The morphology of apoptosis and necrosis of fat cells after photodynamic treatment at a constant temperature in vitro

“…In application of the PDT to fat tissue reduction as a photosensitizer indocyanine green (ICG), NIR-dye that is a cyanine dye used normally in medical diagnostics, could be used. [1][2][3] Diagnostic and therapeutic applications of ICG are successful due to its strong absorption in the NIR, low toxicity and rapid elimination from the body. [4][5][6] It was shown that strong absorption of laser radiation at a wavelength 810 nm by ICG stained tumor induces its local heating and the subsequent destruction, [7][8][9] or due to the PDT.…”