Destruction of the cell membrane and inhibition of cell phosphatidic acid biosynthesis inStaphylococcus aureus: an explanation for the antibacterial mechanism of morusin

Abstract

Morusin from mulberry inhibits the growth of S. aureus by destroying its cell membrane and further moderating the phosphatidic acid biosynthesis pathway.

Prenylated phenolics as promising candidates for combination antibacterial therapy: Morusin and kuwanon G

“…It is worth mentioning that our previous investigations on morusin and kuwanon G found irrelevant antibacterial effects against Gram-negative bacteria ( E. coli , P. aeruginosa ) (data not shown). With respect to morusin, our results are in agreement with previous studies reporting very good and good antibacterial effects against MSSA and S. epidermidis (MIC = 6.30 – 25 and 20 µg/mL, respectively) but moderate and low activity against Gram-negative bacteria (MIC = 62.5 µg/mL against P. aeruginosa, MIC > 100 µg/mL against E. coli ) ( Mazimba et al, 2011 , Pang et al, 2019 , Sohn et al, 2004 , Wu et al, 2019 , Zuo et al, 2018 ). Zuo et al (2018) have recently reported very good to moderate antibacterial effects for morusin against clinical MRSA isolates (MIC = 8 – 32 µg/mL).…”

“…In an attempt to elucidate the mechanisms underlying their antibacterial potential, morusin and kuwanon G have been recently investigated with respect to their effects on MSSA membrane; both compounds were found to disrupt the bacterial membrane ( Pang et al, 2019 , Wu et al, 2019 ). In the present study, we examined their effects on the integrity and morphology of MRSA ( S. aureus ATCC 43300) membrane using the fluorescence and differential interference contrast microscopy and SEM, respectively.…”

“…Morusin (prenylflavone) was reported to possess antioxidant, anti-inflammatory and antitumor activities ( Gao et al, 2017 ) whereas kuwanon G (Diels – Alder type adduct) was found to exhibit antioxidant, anti-inflammatory, immunomodulatory and anti- Ichthyophthirius multifiliis (agent of ichthyophthiriasis) activities ( Guo et al, 2016 , Nasir et al, 2017 ). The up-to-date studies on the antibacterial activity of morusin and kuwanon G focused on susceptibility tests and less on interactions with antibiotics ( Mazimba et al, 2011 , Pang et al, 2019 , Park et al, 2003 , Sohn et al, 2004 , Wu et al, 2019 , Zuo et al, 2018 ). Accordingly, the aim of the present work was to assess the interactions between these two prenylated compounds and antibiotics to find combinations with more efficient antibacterial effects against S. aureus and S .…”

Stress Granule Formation Attenuates RACK1-Mediated Apoptotic Cell Death Induced by Morusin

“…Morusin is an isoprenylated flavone purified from the root bark of Morus alba Linn, exerting numerous health benefits including antinociceptive, antidiabetic, anticonvulsant, antibacterial, and antitumor activities [52][53][54]. In particular, the high antitumor capacity has been intensively tested across many different cancer cell lines.…”

Establishment of a Method for The Distinguishment of Taxilli Herba Parasitizing Mulberry, Willow, and Cinnamon Based on Dual-Component Measurement 

“…Quercitrin, morusin, salicin, and cinnamaldehyde possess known biological activities [26][27][28][29]. The latter three substances are transferred from their respective host trees and accumulate within TH.…”