Destabilizing the interplay between miR-1275 and IGF2BPs by <i>Tamarix articulata</i> and quercetin in hepatocellular carcinoma

Shaalan, Yasmin M; Handoussa, Heba; Youness, R.A.; Assal, R.A.; El‐Khatib, Ahmed H.; Linscheid, Michael; Tayebi, H.M. El; Abdelaziz, Ahmed Ihab

doi:10.1080/14786419.2017.1366478

Cited by 54 publications

(45 citation statements)

References 18 publications

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“…For instance, up-regulation of miR-1275 regulated IGF2BPs to hinder tumour growth in hepatocellular carcinoma. 24 It was reported that miR-1275 exhibited its tumour suppressive role on nasopharyngeal carcinoma cells by down-regulating oncogenic HOXB5, whose expression was negatively related to miR-1275. 25 In our study, we found that miR-1275 was lowly expressed in glioma and its up-regulation could suppress glioma cell function including proliferation, migration and invasion, as well as induce apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Retracted: MircoRNA‐1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1

Wang

Wen

et al. 2018

J Cellular Molecular Medi

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This study was designed to explore the relationship between miR‐1275 and SERPINE1 and its effects on glioma cell proliferation, migration, invasion and apoptosis. Differentially expressed miRNAs and mRNAs in glioma tissues were screened out by bioinformatic analysis. Dual‐luciferase reporter gene assay was used to validate the targeted relationship between miR‐1275 and SERPINE1. qRT‐PCR was used to detect the expression of miR‐1275 and SERPINE1 in glioma tissues. The expressions of SERPINE1 and p53 pathway‐related proteins in glioma cells were detected by western blot. Glioma cell proliferation, apoptosis, migration and invasion were respectively detected by CCK‐8 assay, flow cytometry, wound healing assay and transwell assay. Tumour xenograft model was developed to study the influence of miR‐1275 and SERPINE1 on glioma growth in vivo. The results of microarray analysis, qRT‐PCR and western blot showed that miR‐1275 was low‐expressed while SERPINE1 was high‐expressed in glioma. Dual‐luciferase assay showed that miR‐1275 could bind to SERPINE1. Overexpression of miR‐1275 could promote the p53 pathway‐related proteins’ expression. Highly expressed miR‐1275 could repress the migration, proliferation and invasion of glioma cells while highly expressed SERPINE1 had inverse effects. Tumour xenograft showed that up‐regulated miR‐1275 or down‐regulated SERPINE1 could repress glioma growth in vivo. Up‐regulation of miR‐1275 activated p53 signalling pathway via regulating SERPINE1 and therefore suppressed glioma cell proliferation, invasion and migration, whereas promoted cell apoptosis.

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Section: Discussionmentioning

confidence: 99%

Retracted: MircoRNA‐1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1

Wang

Wen

et al. 2018

J Cellular Molecular Medi

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“…Quercetin antitumor effects have been described in different cancer types, including HCC [1]. In 25 of the articles included in the present review, quercetin efficacy as single treatment was evaluated employing different HCC study models [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38]46,48,49,[51][52][53][54]57]. Antiproliferative effect of this flavonoid alone has been demonstrated in several researches with in vitro models [22][23][24][25][26][27][30][31][32][33]35,38,46,48,49,[51][52][53][54], highlighting the HepG2 cell line as the most used in 21 of the 25 articles [24,25,<...>…”

Section: Antitumor Properties Of Quercetin As Single Agent Against Hccmentioning

confidence: 99%

“…Among included articles, several of them determined effects of the flavonoid in different specific mechanisms [27][28][29]34,38]. These include inhibition of chymotrypsin-like activity of the proteasome, involved in proteasomal regulation of cancer signaling pathways [27,38]; rise of intracellular labile zinc, which has second messenger molecule activities in tumor cells [34]; and modulation of microRNAs expression, highly involved in cancer development and chemoresistance [63], leading to inhibition of the oncogenic RNA-binding proteins insulin-like growth factor-2 binding protein 1 and 3 (IGF2BP1 and IGF2BP3) through the upregulation of miR-1275 [29]. Another study published in 2018 employed quercetin to analyze adequacy of the cellular antioxidant (CAA) assay in HepG2 cells in order to determine the antioxidant activity of extracts from tree nuts [28].…”

Section: Antitumor Properties Of Quercetin As Single Agent Against Hccmentioning

confidence: 99%

Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review

et al. 2019

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Quercetin is a flavonoid present in fruits, vegetables and plants with antioxidant, anti-inflammatory and anticancer properties. Its beneficial activities have been demonstrated in different human pathologies, including hepatoprotective effects against liver disorders. High mortality and late diagnosis of the primary liver tumor hepatocarcinoma (HCC) makes this cancer an interesting target for the study of quercetin effects. Our aim was to systematically review antitumor activities of quercetin in HCC preclinical studies employing single, encapsulated, combined or derived quercetin forms. Literature search was conducted in PubMed, Scopus and Web of Science (WOS), and 39 studies were finally included. We found that 17 articles evaluated quercetin effects alone, six used encapsulated strategy, 10 combined this flavonoid, two decided to co-encapsulate it and only four studied effects of quercetin derivatives, highlighting that only nine included in vivo models. Results evidence the quercetin antiproliferative and proapoptotic properties against HCC either alone and with the mentioned strategies; nevertheless, few investigations assessed specific activities on different processes related with cancer progression. Overall, further studies including animal models are needed to deeper investigate the precise mechanisms of action of quercetin as antitumor agent, as well as the potential of novel strategies aimed to improve quercetin effects in HCC.

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“…However, quercetin dose-dependently reduced ROS and miR-21 and simultaneously upregulated PDCD4 (shown in Figure 2). 28 Detailed mechanistic insights revealed that miR-200b-3p switched symmetrical to the asymmetrical division of the cells by reversal of the Notch/Numb ratio and the inhibition of the self-renewal capacity. NF-κB was also inhibited by quercetin.…”

Section: Regulation Of Mirnas By Quercetin In Different Types Of Camentioning

confidence: 99%

“…Quercetin significantly enhanced miR-1275, whereas substantially downregulated IGF2BP1 and IGF2BP3 levels in Huh-7 cells. 28 Detailed mechanistic insights revealed that miR-200b-3p switched symmetrical to the asymmetrical division of the cells by reversal of the Notch/Numb ratio and the inhibition of the self-renewal capacity. 29 The lower level of miR-200b-3p promoted Notch signaling and promoted daughter cells to become symmetrical in appearance whereas higher levels of miR-200b-3p exerted repressive effects on Notch signaling and promoted daughter cells to become asymmetrical.…”

Section: Quercetin In Different Types Of Cancersmentioning

confidence: 99%

Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

Farooqı

Jabeen

Attar

et al. 2018

J of Cellular Biochemistry

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Recent technological and analytical breakthroughs in genomics and proteomics have deepened our understanding related to the multifaceted nature of cancer. Because of therapeutically challenging nature of cancer, there has been a renewed interest in phytochemistry, and much attention is currently being given to the identification of signaling pathway inhibitors. Data obtained through high-throughput technologies has provided a broader landscape of wiring maps of complex oncogenic signaling networks, thus revealing novel therapeutic opportunities. Increasingly, it is being realized that although our knowledge related to physiological and pathophysiological roles of signal transduction cascades has evolved rapidly, the clinical development of signaling pathway inhibitors has been challenging. Quercetin has attracted considerable attention because of its amazingly high pharmacological value. Research over decades has sequentially shown that quercetin effectively inhibited cancer development and progression. In this review, we have attempted to set the spotlight on the regulation of different cell signaling pathways by quercetin. We partition this multicomponent review into how quercetin effectively regulates the Wnt/β-catenin pathway, Janus kinase-signal transducer and activator of transcription pathway, and vascular endothelial growth factor/vascular endothelial growth factor receptor signaling cascade in different types of cancers. We also provide an overview of the regulation of NOTCH and SHH pathways by quercetin. MicroRNAs (miRNAs) have also emerged as versatile regulators of cancer, and contemporary studies have shed light on the ability of quercetin to control different miRNAs in various cancers. We have scattered information related to NOTCH and SHH pathways, and future studies must converge on the investigation of these pathways to see how quercetin modulates the signaling machinery of these pathways.

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Destabilizing the interplay between miR-1275 and IGF2BPs by Tamarix articulata and quercetin in hepatocellular carcinoma

Cited by 54 publications

References 18 publications

Retracted: MircoRNA‐1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1

Retracted: MircoRNA‐1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1

Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review

Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

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