Destabilization of amyloid fibrils on interaction with MoS<sub>2</sub>-based nanomaterials

Mudedla, Sathish Kumar; Murugan, Natarajan Arul; Subramanian, V.; Ågren, Hans

doi:10.1039/c8ra10184a

Cited by 19 publications

(17 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides, MoS 2 can quench ·NO, as observed in ESR spin trapping experiments [ 80 ]. As well as their anti-redox activity, Mo-based NMs can inhibit Aβ aggregation, which has been confirmed by molecular dynamics simulations [ 76 , 81 ]. The results of the simulations showed that an MoS 2 nanotube could destabilize amyloid fibrils when they interacted.…”

Section: Nms Mimic Enzyme Activity To Scavenge Ronsmentioning

confidence: 77%

See 1 more Smart Citation

Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

et al. 2022

View full text Add to dashboard Cite

Overproduced reactive oxygen and reactive nitrogen species (RONS) in the brain are involved in the pathogenesis of several neurological diseases, such as Alzheimer's disease, Parkinson's disease, traumatic brain injury, and stroke, as they attack neurons and glial cells, triggering cellular redox stress. Neutralizing RONS, and, thus, alleviating redox stress, can slow down or stop the progression of neurological diseases. Currently, an increasing number of studies are applying nanomaterials (NMs) with anti-redox activity and exploring the potential mechanisms involved in redox stress-related neurological diseases. In this review, we summarize the anti-redox mechanisms of NMs, including mimicking natural oxidoreductase activity and inhibiting RONS generation at the source. In addition, we propose several strategies to enhance the anti-redox ability of NMs and highlight the challenges that need to be resolved in their application. In-depth knowledge of the mechanisms and potential application of NMs in alleviating redox stress will help in the exploration of the therapeutic potential of anti-redox stress NMs in neurological diseases. Graphical Abstract

show abstract

Section: Nms Mimic Enzyme Activity To Scavenge Ronsmentioning

confidence: 77%

“…The results of the simulations showed that an MoS 2 nanotube could destabilize amyloid fibrils when they interacted. Moreover, the surface of an MoS 2 nanotube can inhibit the growth of smaller protofibrils into mature fibrils and also break already-formed fibrils [ 81 ].…”

Section: Nms Mimic Enzyme Activity To Scavenge Ronsmentioning

confidence: 99%

Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In the same work, it has been proved that β-Si 3 N 4 nanosheets exhibit a semiconducting behavior with a band gap of about 2 eV. Taking into account the findings that semiconducting MoS 2 [24] or graphene [25] monolayers indeed destabilize amyloid beta fibrils [26], we therefore hypothesized that 2D Si 3 N 4 may exhibit the same effect based on the structural and electronic similarities. As a result, the present work was devoted to evaluating the biocompatibility of β-Si 3 N 4 monolayers as a first step in testing our hypothesis in case they are released in vivo.…”

Section: Introductionmentioning

confidence: 88%

Biocompatibility of 2D Silicon Nitride: Interaction at the Nano-Bio interface

Shekaari¹,

Jafari²

2021

Preprint

View full text Add to dashboard Cite

Determining potential abilities of nanostructures to induce toxicity to biological molecules is still a convoluted challenge in the realm of nanomedicine. Based on the unprecedented achievements of twodimensional nanomaterials in nearly all areas of applied sciences particularly medicine, we carried out all-atom molecular dynamics simulations to assess the biologically-important, yet-unmapped issue of the biocompatibility of 2D, hexagonal β-Si 3 N 4 nanosheet via investigating its possible cross interactions with both human serum albumin (HSA) and p53 tumor suppressor. Examining the conventional MD indicators in the presence and absence of the monolayer revealed that hexagonal Si 3 N 4 nanosheet weakly binds to these two proteins without inducing any important, dramatic change to their secondary structures, revealing accordingly the biological compatibility of the monolayer in case it is released as therapeutics or carriers in vivo. This finding was also broadly supported by the related, time-dependent behaviors of the protein-monolayer as well as the protein-water interaction energies.

show abstract

“…The basal plane of TMD NSs can adsorb or conjugate various aromatics (e.g., pyridine and purine) and other compounds. Mudedla et al investigated the interaction between Aβ fibrils and MoS 2 -based materials and found that MoS 2 nanotubes could inhibit the aggregation of smaller protofibrils to matured fibrils and bust the preformed fibrils [144]. Wang The 2D TMDs analogous to graphene exhibit excellent properties, such as high colloidal stability in aqueous media and a high mass extinction coefficient at 800 nm [147].…”

Section: Transition Metal Dichalcogenidesmentioning

confidence: 99%

Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides

et al. 2021

View full text Add to dashboard Cite

The aberrant aggregation of amyloid-β (Aβ) peptides in the brain has been recognized as the major hallmark of Alzheimer’s disease (AD). Thus, the inhibition and dissociation of Aβ aggregation are believed to be effective therapeutic strategiesforthe prevention and treatment of AD. When integrated with traditional agents and biomolecules, nanomaterials can overcome their intrinsic shortcomings and boost their efficiency via synergistic effects. This article provides an overview of recent efforts to utilize nanomaterials with superior properties to propose effective platforms for AD treatment. The underlying mechanismsthat are involved in modulating Aβ aggregation are discussed. The summary of nanomaterials-based modulation of Aβ aggregation may help researchers to understand the critical roles in therapeutic agents and provide new insight into the exploration of more promising anti-amyloid agents and tactics in AD theranostics.

show abstract

Destabilization of amyloid fibrils on interaction with MoS₂-based nanomaterials

Abstract: The present work computationally establishes that the structure and energetics of fibril-like biomacromolecules can be modulated by confining them on the MoS2 based nanomaterials.

Cited by 19 publications

References 71 publications

Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

Biocompatibility of 2D Silicon Nitride: Interaction at the Nano-Bio interface

Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides

Contact Info

Product

Resources

About

Destabilization of amyloid fibrils on interaction with MoS2-based nanomaterials

Abstract: The present work computationally establishes that the structure and energetics of fibril-like biomacromolecules can be modulated by confining them on the MoS2 based nanomaterials.

Cited by 19 publications

References 71 publications

Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

Biocompatibility of 2D Silicon Nitride: Interaction at the Nano-Bio interface

Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides

Contact Info

Product

Resources

About

Destabilization of amyloid fibrils on interaction with MoS₂-based nanomaterials