Destabilization Mechanism of Ionic Surfactant on Curcumin Nanocrystal against Electrolyte

Abstract

Abstract:We have successfully developed curcumin nanosuspension aimed for oral delivery. The main purpose is to improve bioavailability through enhancing its solubility. The nanoparticles were stabilized using various stabilizers including polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), sodium carboxymethylcellulose (Na-CMC), d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS), and sodium dodecyl sulfate (SDS). The average diameter of particles, microscopic appearance, and sedimentation of each preparation was observed and compared. Each stabilizer demonstrated different degree of inhibition of particle aggregation under electrolyte-containing simulated gastrointestinal (GIT) fluid. Non-ionic stabilizers (PVA, PVP, and TPGS) has shown to preserve the nanosuspension stability against electrolytes. In contrast, strong ionic surfactants such as SDS were found to be very sensitive to electrolytes. The results can provide useful information for the formulators to choose the most suitable stabilizers by considering the nature of stabilizers and physiological characteristics of target site of the drug.

A New Approach To The Treatment of Leıshmaniasis: Quercetin-Loaded Polycaprolactone Nanoparticles

“…The larger size of the quercetin-loaded nanoparticles compared to the empty nanoparticles can be considered as an indicator of the efficient and effective encapsulation of quercetin by the PCL nanoparticles. In the previous studies, it was stated that the drug-loaded nanoparticles can be larger in size compared to the empty nanoparticles (28,29). It was found that, particularly in cancer research, carrier systems smaller than 500 nm are more successful in delivering the drugs to the target tissues, therefore enabling active transport (30).…”