Dess-Martin Periodinane (DMP) in Organic Synthesis-A Septennial Update (2015-till
Date)

Varala, Ravi; Seema, Vittal; Alam, Mohammed Mujahid; Amanullah, Mohammed; Dubasi, Narsimhaswamy

doi:10.2174/0113852728262311231012060626

Cited by 7 publications

(1 citation statement)

References 197 publications

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“…In particular, the synthesis sustainability has been one of the key considerations of the future green chemistry. Compared to the hazardous oxidants used for alcohol oxidations, such as chromium(VI) compounds 34 , Dess-Martin periodinane 35 , pyridinium chlorochromate (PCC) 36 , and manganese dioxide (MnO2) 37 , molecular oxygen from air is a promising terminal oxidant due to its low cost and high atomic efficiency with minimal wastes generated 38 . Moreover, the implementation of molecular oxygen as the oxidant could operate under milder conditions, thus tolerating sensitive functional groups and enabling improved selectivity in the oxidation of alcohols to aldehydes.…”

Section: Llm-based Agents For End-to-end Chemical Synthesis Reaction ...mentioning

confidence: 99%

Accelerated end-to-end chemical synthesis development with large language models

Ruan,

Lu,

et al. 2024

Preprint

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The rapid emergence of large language model (LLM) technology presents significant opportunities to facilitate the development of synthetic reactions. In this work, we leveraged the power of GPT-4 to build a multi-agent system to handle fundamental tasks involved throughout the chemical synthesis development process. The multi-agent system comprises six specialized LLM-based agents, including Literature Scouter, Experiment Designer, Hardware Executor, Spectrum Analyzer, Separation Instructor, and Result Interpreter, which are pre-prompted to accomplish the designated tasks. A web application was built with the multi-agent system as the backend to allow chemist users to interact with experimental platforms and analyze results via natural language, thus, requiring zero-coding skills to allow easy access for all chemists. We demonstrated this multi-agent system on the development of a recently developed copper/TEMPO catalyzed aerobic alcohol oxidation to aldehyde reaction, and this LLM multi-agent copiloted end-to-end reaction development process includes: literature search and information extraction, substrate scope and condition screening, reaction kinetics study, reaction condition optimization, reaction scale-up and product purification. This work showcases the trilogy among chemist users, LLM-based agents, and automated experimental platforms to reform the traditional expert-centric and labor-intensive reaction development workflow.

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Section: Llm-based Agents For End-to-end Chemical Synthesis Reaction ...mentioning

confidence: 99%

Accelerated end-to-end chemical synthesis development with large language models

Ruan,

Lu,

et al. 2024

Preprint

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Recent advances in TBHP‐promoted heterocyclic ring construction via annulation/cyclization

Varala,

Seema,

Amanullah

et al. 2024

Journal of Heterocyclic Chem

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One of the most often utilized hydroperoxides in an array of oxidation strategies is tert‐butyl hydroperoxide (tBuOOH, TBHP). The key reasons for rising utility of TBHP are its low cost, environmental friendliness, high efficiency, and ability to replace hazardous or rare heavy metal oxidants. In this sexennial update, we concisely and critically discussed the applications of TBHP in heterocyclic ring formations starting from 2018 to date. Merits and demerits of its utility, scope of a synthetic organic transformation along with mechanistic logistics are the key features of this review.

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tert‐Butyl Hydroperoxide (TBHP): Recent Progress in C−H Functionalization and Heteroatom‐Heteroatom Bond Formations

Varala,

Seema,

Hussein

et al. 2024

ChemistrySelect

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Abstracttert‐Butyl hydroperoxide (tBuOOH, TBHP) is a commonly used hydroperoxide in many oxidation processes. The primary factors contributing to the increasing usefulness of TBHP include its affordability, eco‐friendliness, exceptional efficacy, and capacity to substitute harmful or rare heavy metal oxidants. In this sexennial update, we thoroughly and critically examined the most noteworthy applications of TBHP in C−H functionalization and heteroatom‐heteroatom bond formation reactions from 2018 till the present. The review has been subdivided based on the nature of the bonds being formed. The review focuses on the advantages and disadvantages of using synthetic organic transformations, as well as the breadth of their use and the underlying mechanisms involved.

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Dess-Martin Periodinane (DMP) in Organic Synthesis-A Septennial Update (2015-till Date)

Cited by 7 publications

References 197 publications

Accelerated end-to-end chemical synthesis development with large language models

Accelerated end-to-end chemical synthesis development with large language models

Recent advances in TBHP‐promoted heterocyclic ring construction via annulation/cyclization

tert‐Butyl Hydroperoxide (TBHP): Recent Progress in C−H Functionalization and Heteroatom‐Heteroatom Bond Formations

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