2013
DOI: 10.1183/09059180.00005812
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Desquamative interstitial pneumonia: an analytic review with an emphasis on aetiology

Abstract: Desquamative interstitial pneumonia (DIP) is characterised by the accumulation of numerous pigmented macrophages within most of the distal airspace of the lung and, sometimes, the presence of giant cells. Diagnosis of DIP is not easy and requires surgical lung biopsy. DIP is usually associated with tobacco smoke. However, the association between smoking and DIP is less robust than that with respiratory bronchiolitis with interstitial lung disease or pulmonary Langerhans' cell histiocytosis; approximately 10-42… Show more

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Cited by 77 publications
(58 citation statements)
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References 50 publications
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“…Indeed, the pathologic pattern observed in CTD does not seem to affect the prognosis and survival as clearly as in the idiopathic setting. Although patients with idiopathic NSIP [20] or idiopathic desquamative interstitial pneumonia [21] have a dramatically better long-term survival than those with IPF [22][23][24], such a difference was not found in patients with systemic sclerosis or rheumatoid arthritis [3,10]. Studies correlating the pathological pattern with outcome all suffer the limitation of a high risk of constitutive selection bias, with lung biopsy being performed in individuals with the least typical pattern of disease at imaging.…”
Section: Does the Diagnosis Of Established Ctd Affect Prognosis Or Mamentioning
confidence: 99%
“…Indeed, the pathologic pattern observed in CTD does not seem to affect the prognosis and survival as clearly as in the idiopathic setting. Although patients with idiopathic NSIP [20] or idiopathic desquamative interstitial pneumonia [21] have a dramatically better long-term survival than those with IPF [22][23][24], such a difference was not found in patients with systemic sclerosis or rheumatoid arthritis [3,10]. Studies correlating the pathological pattern with outcome all suffer the limitation of a high risk of constitutive selection bias, with lung biopsy being performed in individuals with the least typical pattern of disease at imaging.…”
Section: Does the Diagnosis Of Established Ctd Affect Prognosis Or Mamentioning
confidence: 99%
“…The typical pathological lesion of clusters of pigmented macrophages, which is observed in RBILD, is rarely seen in non-smokers. 4,5 The clinical presentation of this patient with predominant dyspnoea was compatible with a clinical diagnosis of interstitial lung disease.…”
Section: Discussionmentioning
confidence: 69%
“…Corticosteroid therapy may be used in conjunction with smoking cessation. This results in stabilisation or improvement in the majority of patients [21]. Residual GGO after treatment is common and may represent microscopic fibrosis as with respiratory bronchiolitis.…”
Section: Smoking-related Lung Diseasementioning
confidence: 99%