Desquamative interstitial pneumonia: A case report

Lovrenski, Aleksandra; Eri, Živka; Tegeltija, Dragana; Kasikovic-Lecic, Svetlana; Panjković, Milana

doi:10.2298/sarh1410602l

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…DIP is characterized by bilateral areas of grossly glassy opacity in the lungs on imaging and pathologically by macrophage infiltration of the alveoli. Currently, the main treatment approach involves counseling patients to stop smoking and using glucocorticoids ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

“…Patients may only exhibit an increase in one or more of these cell types ( 10 , 21 , 22 ). Previously, an open-chest biopsy was considered the most powerful means of identifying DIP ( 20 , 23 ). On chest radiography, the benign tumor typically appears nodular and is located mostly in the lower lobes, with peripheral lesions of variable sizes.…”

Section: Discussionmentioning

confidence: 99%

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Desquamative interstitial pneumonia: A case report

Zhang,

Yu,

Yang

et al. 2024

Exp Ther Med

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Diffuse cystic lung diseases (DCLDs) are a group of heterogeneous lung diseases that are characterized by inflated spaces or cysts within the lung parenchyma. They also exhibit similar imaging characteristics and clinical manifestations compared with those of cystic lesions, such as pulmonary cavities, emphysema, bronchiectasis and honeycomb lung. The most common DCLDs encountered in the clinic include lymphangioleiomyomatosis, Birt-Hogg-Dubé syndrome, Langerhans cell histiocytosis and lymphocytic interstitial pneumonia. In particular, accurate diagnosis of DCLDs in terms of the different lesions found is important, because their clinical courses, prognoses and treatment strategies vary widely. However, because DCLDs usually have overlapping clinical presentations, diagnosis typically requires a combination of clinical considerations that take into account characteristics of the cyst, its distribution, organ of origin and background parenchymal findings. The present report documents the case of a 73-year-old man diagnosed with desquamative interstitial pneumonia (DIP). The patient was admitted to the hospital due to chest tightness, shortness of breath and intermittent fever. The patient had been a smoker for >60 years and had stopped smoking for 6 months before being admitted. A transbronchial lung biopsy, bronchoscopy and alveolar lavage cytopathogen culture were performed to confirm the diagnosis of desquamative interstitial pneumonia (DIP). The patient was treated with hormonal therapy and advised to abstain from smoking. The diagnosis of DIP in comparison with other DCLDs was summarized for the purpose of providing a clinical basis for the accurate clinical diagnosis of DIP and the development of evidence-based practice guidelines.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Desquamative interstitial pneumonia: A case report

Zhang,

Yu,

Yang

et al. 2024

Exp Ther Med

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Desquamative interstitial pneumonia: a systematic review of its features and outcomes

et al. 2020

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BackgroundDesquamative Interstitial Pneumonia (DIP) is a rare form of idiopathic interstitial pneumonia (IIP). Data on clinical features, aetiology, prognosis and effect of treatment strategies are limited. We aimed to collect all published cases to better characterise DIP.MethodsA systematic literature search was performed for all original cases of adult patients with histopathologically-confirmed DIP. Individual patient data were extracted and summarised.ResultsWe included 68 individual cases and 13 case series reporting on 294 cases. Most common presenting symptoms were dyspnoea and cough. Pulmonary function showed a restrictive pattern (71%) with decreased diffusion capacity. We found a high incidence (81%) of ever smoking in patients with DIP and 22% of patients had other (occupational) exposures. Characteristic features on high-resolution computed tomography (HRCT) scan were bilateral ground-glass opacities with lower lobe predominance (92%). Treatment and duration of treatment widely varied. Initial response to treatment was generally good, but definitely not uniformly so. A significant proportion of patients died (25% of individual cases) or experienced a relapse (18% of individual cases).ConclusionDIP remains an uncommon disease, frequently but not always related to smoking or other exposures. Furthermore, DIP behaves as a progressive disease more often than generally thought, possibly associated with different underlying aetiology.

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Desquamative interstitial pneumonia: A case report

Abstract: Although, as in our case, the majority of DIP patients improve on treatment, some patients still develop progressive irreversible fibrosis despite therapy.

Cited by 2 publications

References 22 publications

Desquamative interstitial pneumonia: A case report

Desquamative interstitial pneumonia: A case report

Desquamative interstitial pneumonia: a systematic review of its features and outcomes

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