Desquamative Gingivitis: Challenges in the Diagnosis

Oliveira, Letícia Almeida; Freitas, Paula Lima; Ferreira, Nathália Hernani; Assunção, José Narciso Rosa; Teixeira, Victor Perez; Almeida, Ricardo Camillo de; Loureiro, Vania

doi:10.1016/j.oooo.2018.02.477

Cited by 1 publication

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“…This may require two separate biopsies, one from the lesion and the perilesional area and one from normal appearing mucosa. Direct immunofluorescence (DIF) should be performed on biopsy specimens from normal-appearing tissue rather than perilesional sites in suspected autoimmune diseases such as CP, BP and PV, as immune deposits in these morbid conditions are present in all oral tissue and the pattern of distribution of immune deposits is more clearly seen in intact epithelium [ 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Diagnostic Approachmentioning

confidence: 99%

Desquamative Gingivitis in the Context of Autoimmune Bullous Dermatoses and Lichen Planus—Challenges in the Diagnosis and Treatment

et al. 2022

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Desquamative gingivitis (DG) is a clinical term that describes erythema, desquamation and erosions of the gingiva, of various etiologies. Although the clinical aspect is not specific for a certain disease, an accurate diagnosis of the underlying disorder is necessary because the disease course, prognosis and treatment vary according to the cause. DG may inflict significant oral discomfort, which is why patients typically present to the dentist for a first consultation, rendering it important for these specialists to be informed about this condition. Our paper aims to review the ethiopatogenesis and diagnostic approach of DG, focusing on the most common underlying disorders (autoimmune bullous dermatoses and lichen planus) and on the management of these patients. Potential etiological agents leading to an inflammatory immune response in the oral mucosa and DG appearance include genetic predisposition, metabolic, neuropsychiatric, infectious factors, medication, dental materials, graft-versus-host reaction and autoimmunity. A thorough anamnesis, a careful clinical examination, paraclinical explorations including histopathological exam and direct immunofluorescence are necessary to formulate an appropriate diagnosis. Proper and prompt management of these patients lead to a better prognosis and improved quality of life, and must include management in the dental office with sanitizing the oral cavity, instructing the patient for rigorous oral hygiene, periodic follow-up for bacterial plaque detection and removal, as well as topical and systemic therapy depending on the underlying disorder, based on treatment algorithms. A multidisciplinary approach for the diagnosis and follow-up of DG in the context of pemphigus vulgaris, bullous pemphigoid, cicatricial pemhigoid or lichen planus is necessary, including consultations with dermatologists, oral medicine specialists and dentists.

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