Desquamative gingivitis: A clinical sign in mucous membrane pemphigoid

Abbayya, Keshava; Kadashetti, Vidya; Baad, Rajendra; Lohana, Mohini

doi:10.4103/2278-9626.163338

Cited by 2 publications

(2 citation statements)

References 9 publications

(12 reference statements)

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“…The common BMMP shows a histological separation of the epithelial layer with the presence of an inflammatory infiltrate [13]. A direct immunofluorescence test also can be performed to detect immunoglobulins, complementing the biopsy [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Benign Mucosal Membrane Pemphigoid as a Differential Diagnosis of Necrotizing Periodontal Disease

Storrer

Rigo

Teixeira³

et al. 2020

Case Reports in Dentistry

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Desquamative gingivitis is an oral sign of systemic changes that may be symptomatic or asymptomatic. It is generally related to immunological changes. This report is aimed at describing the case of a 51-year-old female patient, who presented with clinical desquamative gingivitis and was initially diagnosed and treated as necrotizing periodontal disease, but no improvement. The cause was hypothesized to be an autoimmune disease. Drug therapy was initiated as a combination of prednisone and topical clobetasol propionate 0.5% cream twice a day. After this treatment, there was an improvement in pain and the blistering of the gingiva. However, the gingiva remained erythematous. A biopsy led to the diagnosis of benign mucous membrane pemphigoid (BMMP). The BMMP case reported in this article has been successfully treated with systemic and topical immunosuppressive therapy. The efficacy of systemic corticosteroids with dapsone and multidisciplinary follow-up has been highlighted and can lead to the stabilization and adequate control of the disease.

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Section: Discussionmentioning

confidence: 99%

Benign Mucosal Membrane Pemphigoid as a Differential Diagnosis of Necrotizing Periodontal Disease

Storrer

Rigo

Teixeira³

et al. 2020

Case Reports in Dentistry

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“…The first lesion of MMP occurs once autoantibodies, directed against proteins within the basement membrane zone, acting with complement (C3), cause a subepithelial split and resultant vesicle formation. Antibodies against basement membrane antigens are known in cases of MMP (1)(2)(3). Lesions of MMP could involve any mucosal surface, however, the oral mucosa is involved in more than 80% of cases, seldom with scarring.…”

Section: Introductionmentioning

confidence: 99%

A Challenging in Diagnosis of Mucous Membrane Pemphigoid with Desquamative Gingivitis Presentation: A Case Report

Koopaie

2018

J Arch Mil Med

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Desquamative gingivitis (DG) is a descriptive term, indicating inflamed and peeling gingiva. It is characterized by sloughing of the gingival epithelium as a result of formation and rupture of the vesicle. Consequently, the gingiva appears erythematous and often edematous. Desquamative gingivitis may represent an oral clinical manifestation of various systemic mucocutaneous diseases. This case report is on a 42-year-old female with chief complaint of burning sensation in the anterior maxillary gingiva. The patient did not have any other lesion at other sites of the oral cavity. The patient had been affected by asthma and her medications were salbutamol spray and tab cetirizine. Clinically, anterior gingiva appeared as the presentation of desquamative gingivitis. Therefore, an incisional biopsy of the affected area for histopathologic assessment and an incisional biopsy of clinically normal-appearing gingiva for direct immunofluorescence (DIF) study were performed. The histopathologic report was herpes simplex infection. However, this report was incompatible with the clinical view and the patient history. Therefore, a second biopsy was performed. The second histopathologic report was compatible with MMP. The treatment plan was local corticosteroid with follow-up. At the one-month examination visit, a significant improvement was observed in the clinical view of the gums.

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Desquamative gingivitis: A clinical sign in mucous membrane pemphigoid

Cited by 2 publications

References 9 publications

Benign Mucosal Membrane Pemphigoid as a Differential Diagnosis of Necrotizing Periodontal Disease

Benign Mucosal Membrane Pemphigoid as a Differential Diagnosis of Necrotizing Periodontal Disease

A Challenging in Diagnosis of Mucous Membrane Pemphigoid with Desquamative Gingivitis Presentation: A Case Report

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