Desquamation: It Is Almost All About Proteases

Voegeli, R.; Rawlings, A. V.

doi:10.1007/978-3-642-27606-4_11

Cited by 9 publications

(9 citation statements)

References 160 publications

(261 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using an in vitro model Bronnenberg et al [48] also showed a swollen and altered SC after prolonged loading. Anatomical differences of the heel and sacral SC might explain the different responses to loading: SC at the heels is much thicker and contains more corneodesmosomes up to the upper SC layers compared to sacral SC [49]. Thus heel SC is stiffer compared to the sacral SC.…”

Section: Discussionmentioning

confidence: 95%

Skin response to sustained loading: A clinical explorative study

Kottner

Dobos

Andruck

et al. 2015

Journal of Tissue Viability

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

Skin response to sustained loading: A clinical explorative study

Kottner

Dobos

Andruck

et al. 2015

Journal of Tissue Viability

View full text Add to dashboard Cite

“…Furthermore, studies have indicated that it is neutral and basic amino acids that are important for keratin maintaining its elastic properties [98]. However, with the increased understanding of the dynamic enzymatically driven nature of SC maturation, it has become clear that by maintaining free water in the superficial layers of the SC that the NMF serves another vital function namely to help to preserve the coordinated activity of many classes of hydrolytic enzymes, vital to correct SC maturation, particularly those proteases involved in the process of desquamation [102] and indeed the generation of NMF [103].…”

Section: Filaggrin and Dry Skinmentioning

confidence: 99%

Filaggrin – revisited

Harding

Aho

Bosko

2013

Intern J of Cosmetic Sci

View full text Add to dashboard Cite

SynopsisProfilaggrin (proFLG) and its processing products are critical to the health and appearance of skin. The recent identification of lossof-function filaggrin (FLG) mutations as a predisposing factor in ichthyosis vulgaris and atopic dermatitis has lead to a resurgent interest in this enigmatic protein. Here, we review the literature on the structure and many functions of proFLG, from its role as a filament-aggregating protein and a source of natural moisturizing factor (NMF), to the more recent discoveries of its role in epidermal barrier formation and its more speculative functions as an antimicrobial and sunscreen. Finally, we discuss the relationship of proFLG with dry skin, the influence of moisturizers on NMF generation and speculate on next generation of FLG research. R esum eLa Profilaggrine et ses produits de transformation sont essentiels a la sant e et l'apparence de la peau. L'identification r ecente des mutations de la filaggrine conduisant a la perte de fonction comme un facteur pr edisposant a l' icthyosis vulgaris et a la dermatite atopique a fait emerger un regain d'int erêt pour cette prot eine enigmatique. Ici, nous passons en revue la litt erature sur la structure et les nombreuses fonctions de la profilaggrine, de son rôle en tant que filament d'agr egation des prot eines et de source du Facteur naturel de l'hydratation (NMF), les d ecouvertes les plus r ecentes de son rôle dans la formation de la barri ere epidermique et ses fonctions plus sp eculatives comme compos e antimicrobien et d' ecran solaire. Enfin, nous discutons de la relation de la profilaggrine a la peau s eche, l'influence des cr emes hydratantes sur la production du NMF et de sp eculons sur la prochaine g en eration de la recherche sur la filaggrine.

show abstract

“…Ongoing enzymatic activity leads to processing of several components essential for SC cohesion and desquamation. Serine protease‐mediated breakdown of corneodesmosomes is indispensable for the ordinate release of corneocytes at the SC surface . Processing of glucosylceramides to ‘mature’ sphingolipids is necessary for the correct formation of the lamellar intercellular matrix, and lipid breakdown to free fatty acids contributes to the SC acidification that, in turn, influences enzymatic activity .…”

Section: The Fate Of Various Epidermal Structures On Keratinocyte Cormentioning

confidence: 99%

‘Memory’ of the stratum corneum: exploration of the epidermis’ past

Haftek

2014

Br J Dermatol

View full text Add to dashboard Cite

Summary The stratum corneum (SC) is the final product of the process of epidermal differentiation. Besides its crucial protective role as a physical permeability barrier, this composite structure made of cornified keratinocytes embedded in a layered lipid matrix is also, by nature, a tissue that keeps track of past events occurring in the outermost living layers. In normal human epidermis, formation of the SC is very rapid, and during this cornification process several structures expressed by the last granular layer of keratinocytes become entrapped and immobilized at the cells’ periphery. Cell–cell junctions are obvious targets of transglutaminases that cross‐link junctions’ components within the corneocyte envelopes. Thus, desmosomes and tight junctions (TJs) in living cells become fixed at the corneocyte periphery and cannot be recycled anymore. We have quantified the TJ‐like structures residing in the SC of human skin explants subjected to environmental stress and compared these results with fresh skin controls. Significant overexpression of TJ‐like cell–cell envelope fusions has been observed in the stressed epidermis and in two different hereditary skin diseases characterized by increased SC cohesion. Quantitation of TJ‐like structures has contributed to the interpretation of the diseases’ physiopathology. Other examples of information retrieved from the SC concern fluctuating lipid expression in the course of atopic dermatitis and patterns of corneodesmosome breakdown influencing SC desquamation. It is, therefore, possible to analyse and quantify the traces left in the SC and to draw conclusions on the dynamics of living tissue over the past several days.

show abstract

Desquamation: It Is Almost All About Proteases

Cited by 9 publications

References 160 publications

Skin response to sustained loading: A clinical explorative study

Skin response to sustained loading: A clinical explorative study

Filaggrin – revisited

‘Memory’ of the stratum corneum: exploration of the epidermis’ past

Contact Info

Product

Resources

About