Desoxycorticosterone Secretion Rates in Hyperadrenocorticism1

Crane, Milton G.; Harris, Jennifer

doi:10.1210/jcem-26-10-1135

Cited by 60 publications

(11 citation statements)

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“…Schambelan et al have reported increased excretion of tetrahydrodesoxycorticosterone and tetrahydroxycorticosterone in the ectopic ACTH syndrome associated with hypokalemic alkalosis (28). This has also been reported by others (29,30) and probably accounts for the electrolyte abnormalities in most cases, although Hokfelt (6) failed to demonstrate increased excretion of either steroid in his patient. The levels of urinary and plasma steroids in our patient are closer to those of the hypokalemic group.…”

Section: Discussionsupporting

confidence: 57%

ACTH-Secreting Medullary Carcinoma of the Thyroid Presenting as Severe Idiopathic Osteoporosis and Senile Purpura: Report of a Case and Review of the Literature*

Rosenberg

Hahn

Orth

et al. 1978

The Journal of Clinical Endocrinology & Metabolism

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A 64-yr-old female presented with severe osteoporosis and easy bruisability of over 2-yr duration. Biopsy of a neck mass revealed medullary carcinoma of the thyroid. Subsequently, lymphangitic pulmonary metastases were demonstrated which had been present radiographically for at least 4 yr. Basal serum calcitonin was markedly elevated and increased during calcium infusion. The diagnosis of ectopic ACTH syndrome was first entertained when hypokalemic alkalosis was observed during evaluation of her carcinoma. Elevated urinary 17-hydroxycorticosteroids, 17-ketosteroids, plasma cortisol, and immunoreactive plasma ACTH levels were documented. Adrenal steroidogenesis seemed to suppress on high dose dexamethasone. The primary tumor and its metastases contained high concentrations of immunoreactive ACTH and beta-melanocyte-stimulating hormone. Hepatic metastases contained extremely high concentrations of calcitonin. In contrast to the usual presentation of the ectopic ACTH syndrome as primarily hypokalemic alkalosis and glucose intolerance, patients with relatively benign and indolent ACTH-secreting tumors, such as certain cases of medullary carcinoma of the thyroid, may present with more typical signs and symptoms of Cushing's syndrome. The more pronounced cushingoid features in this latter group presumably reflects a more prolonged period of exposure to elevated glucocorticoid levels. Ten cases of ACTH-secreting medullary carcinoma of the thyroid from the literature are discussed. Extopic ACTH production by such tumors should be considered in the evaluation of patients with Cushing's syndrome or unexplained severe osteopenia.

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Section: Discussionsupporting

confidence: 57%

ACTH-Secreting Medullary Carcinoma of the Thyroid Presenting as Severe Idiopathic Osteoporosis and Senile Purpura: Report of a Case and Review of the Literature*

Rosenberg

Hahn

Orth

et al. 1978

The Journal of Clinical Endocrinology & Metabolism

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“…However, by that time, it had been recognised that little steroid is actually stored within the gland and that, therefore, secreted products were a far better source (Vogt 1943). It was soon shown that DOC is produced by perfused or incubated bovine tissue (Hechter et al 1951, Plager & Samuels 1954 and that it is secreted in vivo in rats (Vinson & Rankin 1965), dogs (Taylor et al 1972b) and humans, both as the free steroid and the sulphate (Crane & Harris 1966, Schambelan & Biglieri 1972, Corsan et al 1997.…”

Section: Beginnings: Isolation and The Bioassay Of Corticosteroidsmentioning

confidence: 99%

The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function

Vinson¹

2011

Journal of Endocrinology

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Over the 70 or so years since their discovery, there has been continuous interest and activity in the field of corticosteroid functions. However, despite major advances in the characterisation of receptors and coregulators, in some ways we still lack clear insight into the mechanism of receptor activation, and, in particular, the relationship between steroid hormone structure and function remains obscure. Thus, why should deoxycorticosterone (DOC) reportedly be a weak mineralocorticoid, while the addition of an 11b-hydroxyl group produces glucocorticoid activity, yet further hydroxylation at C18 leads to the most potent mineralocorticoid, aldosterone? This review aims to show that the field has been confused by the misreading of the earlier literature and that DOC, far from being relatively inactive, in fact has a wide range of activities not shared by the other corticoids. In contrast to the accepted view, the presence of an 11b-hydroxyl group yields, in corticosterone or cortisol, hormones with more limited functions, and also more readily regulated, by 11b-hydroxysteroid dehydrogenase. This interpretation leads to a more systematic understanding of structure-function relationships in the corticosteroids and may assist more rational drug design.

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“…Several papers (Biglieri et al, 1963;Crane and Harris, 1966;Biglieri et al, 1968;Oddie et al, 1972;Ojima, 1978;Fukuchi et al, 1978) have described higher levels of various steroids in cases of primary aldosteronism.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the results, it was reported that other steroids, i.e., 11-deoxycorticosterone (DOC), 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) and corticosterone, as well as aldosterone, were increased in most cases of primary aldosteronism in both in vivo and in vitro studies (Biglieri et al, 1963;Crane and Harris, 1966;Biglieri et al, 1968;Oddie et al, 1972;Ojima, 1978;Fukuchi et al, 1978 Case report…”

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro studies on steroid metabolism in a case of primary aldosteronism with multiple lesions of adenoma and nodular hyperplasia.

et al. 1982

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Desoxycorticosterone Secretion Rates in Hyperadrenocorticism1

Cited by 60 publications

References 0 publications

ACTH-Secreting Medullary Carcinoma of the Thyroid Presenting as Severe Idiopathic Osteoporosis and Senile Purpura: Report of a Case and Review of the Literature*

ACTH-Secreting Medullary Carcinoma of the Thyroid Presenting as Severe Idiopathic Osteoporosis and Senile Purpura: Report of a Case and Review of the Literature*

The mislabelling of deoxycorticosterone: making sense of corticosteroid structure and function

In vivo and in vitro studies on steroid metabolism in a case of primary aldosteronism with multiple lesions of adenoma and nodular hyperplasia.

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