Desoxycholic Acid Enhancement of Orally Administered Reserpine

Oral Absorption of Griseofulvin in Dogs: Increased Absorption via Solid Dispersion - in Polyethylene Glycol 6000

“…However, the in viuo investigation of such systems has been limited. Only sulfathiazole (l), chloramphenicol (4), and reserpine (9) have been studied. Dosage Forms-Four different dosage forms were used for oral studies: 250 mg. of Gris dissolved in 50 ml.…”

Correlation of Pharmacologie Activity and Dissolution Rates of Reserpine-Desoxycholic Acid Dispersions

“…An interesting example of the enhanced pharmacologic activity of such dispersions has been provided by Malone et al (6). The principal reason for the observed effects appears to be particle size reduction.…”

“…Reserpine' and DCA2 dispersions were prepared according to the methods of Malone et al (6) which involve co-precipitation of the materials from chloroform-absolute alcohol solutions upon evaporation of the solvent system. Attempts to determine the dissolution rate of reserpine in aqueous systems were unsuccessful because of assay difficulties and adsorption problems introduced by the extremely low aqueous solubility of the drug.…”

Some Physical Factors Affecting the Enhanced Blepharoptotic Activity of Orally Administered Reserpine-Cholanic Acid Coprecipitates

“…Malone et al (1) have shown that the onset of action and degree of blepharoptotic activity of reserpine is enhanced two to three fold when administered orally to mice as a reserpine-deoxycholic acid coprecipitate. Further studies have demonstrated that this enhancement is not specific to deoxycholic acid, but is obtained with combinations of reserpine and cholic acid, lithocholic acid, and 3,12,24-trihydroxycholane (2).…”

“…The factors involved in the dissolution rate of pharmaceuticals are embodied in the Noyes-Whitney equation (6) or the various modifications thereof (7-10). Accordingly, the in vivo dissolution of the various coprecipitates prepared by Malone et al (1,2) could be influenced by such physicochemical factors as micellar solubilization (1 1-13), and reduction of interfacial tension (14-16), and particle size (17,18).…”