Desorption electrospray ionization high‐resolution mass spectrometry for the fast investigation of natural polysaccharide interactions with a model drug in controlled release systems

Elviri, Lisa; DeRobertis, Simona; Baldassarre, Stefania; Bettini, Ruggero

doi:10.1002/rcm.6932

Cited by 5 publications

(1 citation statement)

References 30 publications

(47 reference statements)

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“…The release mechanism from tablets with different composition (including carrageenan) and associating different drugs (theophylline and metoprolol succinate) was investigated in a recent work [ 257 ]. Yet another work was devoted to studying the behavior of several polysaccharides, including λ-carrageenan, in the release of atenolol from drug tablets [ 258 ]. The role played by drug/polymer interaction on the water uptake, swelling, drug dissolution and drug release was investigated in a study using λ-carrageenan.…”

Section: Drug Delivery Systems Based On Seaweed Sulfated Polysacchmentioning

confidence: 99%

Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications

2016

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In the last decades, the discovery of metabolites from marine resources showing biological activity has increased significantly. Among marine resources, seaweed is a valuable source of structurally diverse bioactive compounds. The cell walls of marine algae are rich in sulfated polysaccharides, including carrageenan in red algae, ulvan in green algae and fucoidan in brown algae. Sulfated polysaccharides have been increasingly studied over the years in the pharmaceutical field, given their potential usefulness in applications such as the design of drug delivery systems. The purpose of this review is to discuss potential applications of these polymers in drug delivery systems, with a focus on carrageenan, ulvan and fucoidan. General information regarding structure, extraction process and physicochemical properties is presented, along with a brief reference to reported biological activities. For each material, specific applications under the scope of drug delivery are described, addressing in privileged manner particulate carriers, as well as hydrogels and beads. A final section approaches the application of sulfated polysaccharides in targeted drug delivery, focusing with particular interest the capacity for macrophage targeting.

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Section: Drug Delivery Systems Based On Seaweed Sulfated Polysacchmentioning

confidence: 99%

Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications

2016

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Ambient Ionisation–High-Resolution Mass Spectrometry

Seró

Núñez

Moyano

2016

Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis

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Chitosan/chondroitin sulfate hydrogels prepared in [Hmim][HSO4] ionic liquid

Nunes

Rufato

Souza

et al. 2017

Carbohydrate Polymers

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[Hmim][HSO] ionic liquid (IL) and bio-renewable sources as chitosan (CHT) and chondroitin sulfate (CS) were used to yield hydrogel-based materials (CHT/CS). The use of IL to solubilize both polysaccharides was considered an innovative way based on "green chemistry" principle, aiming the production of CHT/CS blended systems. CHT/CS hydrogels were carried out in homogeneous medium from short dissolution times. The hydrogels were characterized and achieved with excellent stabilities (in the 1.2-10pH range), larger swelling capacities, as well as devoid of cytotoxicity towards the normal VERO and diseased HT29 cells. The CHT/CS hydrogels carried out in [Hmim][HSO] could be applied in many technological purposes, like medical, pharmaceutical, and environmental fields.

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Desorption electrospray ionization high‐resolution mass spectrometry for the fast investigation of natural polysaccharide interactions with a model drug in controlled release systems

Abstract: These results suggest that DESI-MS has a potential role for the micro-environmental analysis of drug diffusion and surface distribution in polymeric matrices.

Cited by 5 publications

References 30 publications

Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications

Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications

Ambient Ionisation–High-Resolution Mass Spectrometry

Chitosan/chondroitin sulfate hydrogels prepared in [Hmim][HSO4] ionic liquid

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