Desonide nanoencapsulation with açai oil as oil core: Physicochemical characterization, photostability study and in vitro phototoxicity evaluation

Rosa, Philippe; Friedrich, Mariane Lago; Santos, Juliana dos; Nogueira-Librelotto, Daniele Rubert; Maurer, Luana Haselein; Emanuelli, Tatiana; Silva, Cristiane de Bona da; Adams, Andréa Inês Horn

doi:10.1016/j.jphotobiol.2019.111606

Cited by 19 publications

(16 citation statements)

References 43 publications

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“…Regarding the oily core, vegetable oil (such as soybean oil, palm oil, etc.) or fatty acids (such as medium chain triglycerides) are optimal composition oleic phase for nanocapsules fabrication, due to the capacity to dissolve lipophilic drugs and the safety of oil phase [ 31 , 66 , 67 ]. Aside from being drug dissolving media, the oil, which can simultaneously provide a therapeutic functionality, is a prompting candidate to form oleic core of nanocapsules.…”

Section: Current Status Of Nanocapsules: Materials and Formulationmentioning

confidence: 99%

“…Eudragit ® RL 100 nanocapsules loaded with the anti-inflammation desonide drug were developed using açai oil (AO) as oily core. More than be oil core for drug encapsulation, AO also presented anti-inflammatory and anti-proliferative effects contributing to the therapy [ 67 ]. Essential oils, such as turmeric oil and lemongrass oil, have been used as oil core due to their antibacterial, antifungal, antioxidant, antimutagenic and anticarcinogenic properties [ 69 ].…”

Section: Current Status Of Nanocapsules: Materials and Formulationmentioning

confidence: 99%

“…Additionally, nanocapsules can also provide stable fabrication procedures for light-sensitive drugs. Photosensitive drugs such as desonide and ketoprofen have been encapsulated into the oil core of Eudragit ® RL 100 nanocapsules, which was confirmed to enable avoiding drug photodegradation under UV radiation [ 67 , 125 ].…”

Section: Highlighted Applications Of Nanocapsules As Drug Deliverymentioning

confidence: 99%

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Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed.

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Section: Current Status Of Nanocapsules: Materials and Formulationmentioning

confidence: 99%

Section: Current Status Of Nanocapsules: Materials and Formulationmentioning

confidence: 99%

Section: Highlighted Applications Of Nanocapsules As Drug Deliverymentioning

confidence: 99%

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Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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“…showed that encapsulation of desonide (a synthetic non‐fluorinated corticosteroid) in ACO nanocapsules improved photostability against UV‐A and UV‐C light. This formulation also displayed non‐phototoxic properties [154] …”

Section: Fruits and Nuts As Potential Brazilian Renewable Sourcesmentioning

confidence: 97%

Opportunities for the Use of Brazilian Biomass to Produce Renewable Chemicals and Materials

et al. 2020

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This Review highlights the principal crops of Brazil and how their harvest waste can be used in the chemicals and materials industries. The Review covers various plants; with grains, fruits, trees and nuts all being discussed. Native and adopted plants are included and studies on using these plants as a source of chemicals and materials for industrial applications, polymer synthesis, medicinal use and in chemical research are discussed. The main aim of the Review is to highlight the principal Brazilian agricultural resources; such as sugarcane, oranges and soybean, as well as secondary resources, such as andiroba brazil nut, buriti and others, which should be explored further for scientific and technological applications. Furthermore, vegetable oils, carbohydrates (starch, cellulose, hemicellulose, lignocellulose and pectin), flavones and essential oils are described as well as their potential applications.

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“…It was observed that cell viability in the presence of UV filter nanocapsules improved 17%, increasing the safety of the UV filter in sunscreen formulations [ 119 ]. Other molecules have been successfully encapsulated into nanocapsules, forming promising formulations to be applied in the cosmetic field such as dutasteride (used in the treatment of alopecia) and desonide (used in atopic dermatitis) [ 120 , 121 ].…”

Section: Nanocarriersmentioning

confidence: 99%

Nanocarriers as Active Ingredients Enhancers in the Cosmetic Industry—The European and North America Regulation Challenges

Oliveira

Coelho²,

Teixeira

et al. 2022

Molecules

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“Flawless skin is the most universally desired human feature” is an iconic statement by Desmond Morris. Skin indicates one´s health and is so important that it affects a person’s emotional and psychological behavior, these facts having propelled the development of the cosmetics industry. It is estimated that in 2023, this industry will achieve more than 800 billion dollars. This boost is due to the development of new cosmetic formulations based on nanotechnology. Nanocarriers have been able to solve problems related to active ingredients regarding their solubility, poor stability, and release. Even though nanocarriers have evident benefits, they also present some problems related to the high cost, low shelf life, and toxicity. Regulation and legislation are two controversial topics regarding the use of nanotechnology in the field of cosmetics. In this area, the U.S. FDA has taken the lead and recommended several biosafety studies and post-market safety evaluations. The lack of a global definition that identifies nanomaterials as a cosmetic ingredient is a hindrance to the development of global legislation. In the EU, the legislation regarding the biosafety of nanomaterials in cosmetics is stricter. “The cost is not the only important issue, safety and the application of alternative testing methods for toxicity are of crucial importance as well”.

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Desonide nanoencapsulation with açai oil as oil core: Physicochemical characterization, photostability study and in vitro phototoxicity evaluation

Cited by 19 publications

References 43 publications

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Opportunities for the Use of Brazilian Biomass to Produce Renewable Chemicals and Materials

Nanocarriers as Active Ingredients Enhancers in the Cosmetic Industry—The European and North America Regulation Challenges

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