Desmosomes: Regulators of Cellular Signaling and Adhesion in Epidermal Health and Disease

Johnson, Jerry J.; Najor, Nicole A.; Green, Kathleen J.

doi:10.1101/cshperspect.a015297

Cited by 107 publications

(102 citation statements)

References 176 publications

(207 reference statements)

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“…inhibitors (AZD8055 and torin1) resulted in decreased levels of DSP1/2 and DSG1 (see below). A subset of desmosome proteins undergo differential expression during keratinocyte maturation (47); for example, DSG1 is expressed in the superficial epidermis, while DSG3 is predominantly expressed in basal cells (Figure 3B). Since there was defective keratinocyte differentiation in the cKO models, the decrease in some desmosomal components (such as DSG1) could be exacerbated by this maturation defect.…”

Section: Resultsmentioning

confidence: 99%

mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation

Asrani¹,

Sood²,

Torres³

et al. 2017

Journal of Clinical Investigation

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Section: Resultsmentioning

confidence: 99%

mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation

Asrani¹,

Sood²,

Torres³

et al. 2017

Journal of Clinical Investigation

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“…Dsg2 and Dsc2 are the primary isoforms in simple epithelia and are present at low levels in the basal layer of stratified epithelia, such as the epidermis (Garrod and Chidgey 2008). Dsg1/3 and Dsc1/3 are present in stratified epithelia and Dsg4 is found in stratified epithelia and hair (Garrod and Chidgey 2008; Brooke et al 2012; Johnson et al 2014). Desmosomal cadherins are important in regulating normal physiological processes, such as epithelial morphogenesis and differentiation.…”

Section: Desmosomal Cadherinsmentioning

confidence: 99%

“…They act as anchors linking the intermediate filament (IF) cytoskeletons of neighboring cells thus forming an integrated, mechanically resistant unit throughout a tissue. In addition to mediating adhesion, desmosomes have been recognized as signaling scaffolds that regulate pathways involved in normal physiological processes such as proliferation and differentiation (Johnson et al 2014). …”

Section: Introductionmentioning

confidence: 99%

Desmosome regulation and signaling in disease

2015

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Desmosomes are cell-cell adhesive organelles with a well-known role in forming strong intercellular adhesion during embryogenesis and in adult tissues subject to mechanical stress, such as the heart and skin. More recently, desmosome components have also emerged as cell signaling regulators. Loss of expression or interference with the function of desmosome molecules results in diseases of the heart and skin and contributes to cancer progression. However, the underlying molecular mechanisms that result in inherited and acquired disorders remain poorly understood. To address this question, researchers are directing their studies towards determining the functions that occur inside and outside of the junctions and the extent to which functions are adhesion-dependent or independent. This review focuses on recent discoveries that provide insights into the role of desmosomes and desmosome components in cell signaling and disease; wherever possible, we address molecular functions within and outside of the adhesive structure.

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“…In both areas stimulating recent discoveries have been made. We refer readers to other recent related reviews Nekrasova and Green 2013;Kowalczyk and Green 2013;Berika and Garrod 2014;Garrod and Tabernero 2014;Johnson et al 2014). …”

Section: Introductionmentioning

confidence: 96%

Desmosomal Cadherins

Chidgey

Garrod

2016

The Cadherin Superfamily

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The desmosomal cadherins (DCs) are adhesion molecules of desmosomes, intercellular junctions of epithelia and cardiac muscle. DCs have the unique ability to adopt a hyperadhesive state that is characterised by enhanced stability and adhesive strength. Hyperadhesion is important in embryonic development and wound healing, and DC expression is tightly regulated at the transcriptional and posttranslational levels. Desmosomes act as signalling centres and DCs have been linked to an array of intracellular signal transduction pathways that control cell proliferation and differentiation. DCs are targets of autoantibodies, bacterial toxins and mutations, resulting in skin blistering disease, cardiomyopathy and sometimes both. Here we consider the structure and function of the desmosomal cadherins, and their role in normal tissue biology and human disease.

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Desmosomes: Regulators of Cellular Signaling and Adhesion in Epidermal Health and Disease

Cited by 107 publications

References 176 publications

mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation

mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation

Desmosome regulation and signaling in disease

Desmosomal Cadherins

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