Desmosomal Adhesion In Vivo

Berika, Mohamed; Garrod, David R.

doi:10.3109/15419061.2013.876018

Cited by 34 publications

(35 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hyperadhesion functions to maintain tissue integrity and plays an important role in development, wound healing, and skin disease. [74][75][76] No detectable changes in desmosome composition have been associated with hyperadhesive desmosomes. Comparison of the ultrastructure of desmosomes in normal and wound-edge epidermis showed that those of normal epidermis that were hyperadhesive exhibited very prominent midlines, whereas those at the wound edge, many of which were calcium dependent generally lacked midlines, and the intercellular space appeared amorphous.…”

Section: The Dynamic Desmosome: Hyperadhesion and Remodelingmentioning

confidence: 99%

Desmosome assembly, homeostasis, and desmosomal disease

Cirillo¹

2016

CHC

View full text Add to dashboard Cite

Cell-cell adhesion is involved in all aspects of tissue behavior in multicellular organisms, from tissue morphogenesis (regulation of cell shape, apoptosis, cell movement, and development of complex structures) to aging and disease. A major player in the dynamic regulation of intercellular contacts is the desmosome. Knowledge of the desmosome has evolved over 150 years from the notion of a static, punctuate, adhesive barrier structure to one of the finely tuned multifunctional complexes involved in the regulation of numerous and diverse aspects of keratinocyte physiology and disease. In this context, nondesmosomal regulatory molecules have been acquiring increasing importance in the study of desmosome homeostasis and have become part of the extended desmosomal interactome named "desmo-adhesome". Among these associated molecules, kinases are the prominent regulators of both desmosome remodeling and acquisition of hyperadhesion, two novel concepts in cell-cell adhesion. Spatiotemporal changes in the expression and regulation of desmosomal proteins also underlie a number of genetic, infectious, autoimmune, and malignant conditions. In addition to offering a systems-level view of the molecular composition of desmosomes, we also discuss the mechanisms that regulate, and disrupt, desmosome homeostasis.

show abstract

Section: The Dynamic Desmosome: Hyperadhesion and Remodelingmentioning

confidence: 99%

Desmosome assembly, homeostasis, and desmosomal disease

Cirillo¹

2016

CHC

View full text Add to dashboard Cite

show abstract

“…Affecting nearly every tissue where desmosomal proteins are expressed, these disorders include inherited, auto-immune and infectious diseases, as well as cancer. Since their first description as ‘intercellular bridges’ by Giulio Bizzozero in 1864 (Bizzozero, 1864, Calkins and Setzer, 2007, Mazzarello, et al, 2001), desmosomes have become recognized as sites of strong cell-cell adhesion (Berika and Garrod, 2014). Stemming from the Greek words desmos meaning bond or to bind and soma meaning body, the desmosome is a highly ordered and specialized ‘spot-weld’ of intracellular adhesion (Cirillo, 2014).…”

Section: Introductionmentioning

confidence: 99%

Desmosomes in acquired disease

Stahley

Kowalczyk

2015

Cell Tissue Res

View full text Add to dashboard Cite

Desmosomes are cell-cell junctions that mediate adhesion and couple the intermediate filament cytoskeleton to sites of cell-cell contact. This architectural arrangement functions to integrate adhesion and cytoskeletal elements of adjacent cells. The importance of this robust adhesion system is evident in numerous human diseases, both inherited and acquired, that occur when desmosome function is compromised. This review focuses on autoimmune and infectious diseases that impair desmosome function. In addition, we discuss emerging evidence that desmosomal genes are often misregulated in cancer. The emphasis of our discussion is placed on how human diseases inform our understanding of basic desmosome biology, and in turn, how fundamental advances in the cell biology of desmosomes may lead to new treatments for acquired diseases of the desmosome.

show abstract

“…The desmosome is a macromolecular complex that forms a 'spotweld' of strong intercellular adhesion and comprises transmembrane cadherins and cytoplasmic plaque proteins (Berika and Garrod, 2014;Saito et al, 2012). The desmosomal cadherins (desmogleins and desmocollins) link neighboring cells through extracellular adhesive interactions whereas the armadillo protein family members plakoglobin and plakophilin, and the plakin family member desmoplakin contribute to the intracellular plaque (Fig.…”

Section: Introductionmentioning

confidence: 99%

Molecular organization of the desmosome as revealed by direct stochastic optical reconstruction microscopy

Stahley

Bartle

Atkinson

et al. 2016

Journal of Cell Science

View full text Add to dashboard Cite

Desmosomes are macromolecular junctions responsible for providing strong cell-cell adhesion. Because of their size and molecular complexity, the precise ultrastructural organization of desmosomes is challenging to study. Here, we used direct stochastic optical reconstruction microscopy (dSTORM) to resolve individual plaque pairs for inner and outer dense plaque proteins. Analysis methods based on desmosomal mirror symmetry were developed to measure plaque-to-plaque distances and create an integrated map. We quantified the organization of desmoglein 3, plakoglobin and desmoplakin (N-terminal, rod and C-terminal domains) in primary human keratinocytes. Longer desmosome lengths correlated with increasing plaque-to-plaque distance, suggesting that desmoplakin is arranged with its long axis at an angle within the plaque. We next examined whether plaque organization changed in different adhesive states. Plaque-to-plaque distance for the desmoplakin rod and C-terminal domains decreased in PKP-1-mediated hyperadhesive desmosomes, suggesting that protein reorganization correlates with function. Finally, in human epidermis we found a difference in plaque-to-plaque distance for the desmoplakin Cterminal domain, but not the desmoplakin rod domain or plakoglobin, between basal and suprabasal cells. Our data reveal the molecular organization of desmosomes in cultured keratinocytes and skin as defined by dSTORM.

show abstract

Desmosomal Adhesion In Vivo

Cited by 34 publications

References 92 publications

Desmosome assembly, homeostasis, and desmosomal disease

Desmosome assembly, homeostasis, and desmosomal disease

Desmosomes in acquired disease

Molecular organization of the desmosome as revealed by direct stochastic optical reconstruction microscopy

Contact Info

Product

Resources

About