Desmoplastic Small Round Cell Tumor of the Pleura

Parkash, Vinita; Gerald, William L.; Parma, A; Miettinen, Markku; Rosaí, Juan

doi:10.1097/00000478-199506000-00006

Cited by 157 publications

(84 citation statements)

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“…DSRCT is a neoplasm that, although it most commonly arises in the abdominal or pelvic peritoneum in children and young adults, 34 has also been reported, although less frequently, in the pleura, [35][36][37] as well as in older individuals. 34 In addition to its characteristic pattern of 'small blue cells' embedded in a dense fibrous stroma, DSRCTs may also exhibit a wide range of other morphologic features and, therefore, may potentially be confused with mesotheliomas, particularly those exhibiting small cell morphology.…”

Section: Discussionmentioning

confidence: 99%

Mesotheliomas with small cell features: report of eight cases

Ordóñez

2012

Modern Pathology

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Mesotheliomas with small cell morphology are rare and only one study of such cases has been published. As a result of their rare occurrence, some investigators have cast doubt on the existence of such a histologic variant of mesothelioma. This investigator reports a series of eight cases of epithelioid mesothelioma with small cell features, all of which originated in the pleura. Seven of the patients were men and one was a woman. Four patients had a history of asbestos exposure. Histologically, four of the mesotheliomas were epithelioid and four biphasic. The proportion of small cells seen in these cases constituted 80 to 100% of the tumor included in the biopsy material and 15 to 20% of the tumor present in the pneumonectomy specimens. Immunoreactivity for calretinin, keratin 5/6, keratin 7, pan-keratin, WT1, podoplanin, and mesothelin was seen in all cases tested for these markers. All of the cases were negative for MOC-31, Ber-EP4, CEA, CD15, TAG-72, TTF-1, chromogranin A, synaptophysin, CD99, and desmin. The mean survival of the six patients for whom this information was available was 8.2 months. It is important for pathologists to be aware that mesotheliomas can present small cell features and, because of this, they can be confused with other malignancies that can exhibit similar morphology. The value of immunohistochemistry in the differential diagnosis of these tumors is discussed.

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Section: Discussionmentioning

confidence: 99%

Mesotheliomas with small cell features: report of eight cases

Ordóñez

2012

Modern Pathology

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“…A multipotent progenitor cell residing in the mesothelium or adjacent mesenchyme has been implicated in the histogenesis of both desmoplastic small round cell tumors (DSRCT) and mesotheliomas (38,53,54). Both of these neoplasms have been shown to coexpress keratin, vimentin, desmin and, interestingly, sometimes even neural markers such as NSE, Leu 7, chromogranin and synaptophysin.…”

Section: Discussionmentioning

confidence: 99%

Primary Mesenteric Malignant Mixed Mesodermal (Müllerian) Tumor with Neuroendocrine Differentiation

Cokelaere¹,

Michielsen

Vos³

et al. 2001

Modern Pathology

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Extragenital malignant mixed mesodermal (mülle-rian) tumors (MMMT) are rare neoplasms, with but 24 well documented cases in the literature. Neuroendocrine differentiation in mixed müllerian neoplasms has been mentioned only anecdotally. We report on the clinical, pathological, and immunohistochemical features of a hitherto-undescribed extragenital MMMT with prominent neuroendocrine differentiation arising from the jejunal mesentery. This lesion was composed of a poorly differentiated epithelial component and a spindle cell component with heterologous (rhabdomyoblastic) differentiation. The bulk of the tumor consisted of small cell neuroendocrine carcinoma, which exhibited strong immunoreactivity for NSE, LEU-7, chromogranin A and synaptophysin. Electronmicroscopy confirmed the presence of neurosecretory dense-core granules. The primary mesenteric origin of the tumor was established at autopsy. Along with a brief review of previously reported extragenital MMMT some histogenetic concepts relevant to this case are discussed.

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“…1 Recently, some reports have described an extra-abdominal location as a primary site. 7,8 The intra-abdominal tumor of the current case occurred in the retrovesical space, which has been rarely recorded, but several cases with urological symptoms have been reported. Of the 19 patients described by Gerald et al, 13 had difficulty in voiding.…”

Section: Discussionmentioning

confidence: 81%

“…The combined histologic and immunohistologic findings were basically identical to previous reports of DSRCT. [1][2][3][4][5][6][7][8] Although the staining for vimentin was negative, DSRCT usually showed a strong immunoreactivity for vimentin, but weak or negative reactivity has been shown in some cases. 2,3 Some reports have described a recurring translocation, t(11;22)(p13; q11.2) in DSRCT.…”

Section: Discussionmentioning

confidence: 99%

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Retrovesical desmoplastic small round cell tumor in a patient with urinary frequency

et al. 2001

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A 21-year-old man with urological symptoms was found to have a large abdominal tumor in the retrovesical space between the bladder and the rectosigmoid colon. Radiologic findings revealed little evidence confirming the diagnosis. A transrectal biopsy failed to disclose the histopathologic origin of the tumor. An exploratory laparotomy with a complete surgical resection was impossible, so a wedge biopsy was performed. Combined histologic and immunohistochemical findings revealed the features of desmoplastic small round cell tumor (DSRCT). Despite subsequent multiagent chemotherapy, the patient died as a result of the growing tumor and liver metastasis. There have been only two prior reports of this neoplasm in the urological literature.

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Desmoplastic Small Round Cell Tumor of the Pleura

Cited by 157 publications

References 0 publications

Mesotheliomas with small cell features: report of eight cases

Mesotheliomas with small cell features: report of eight cases

Primary Mesenteric Malignant Mixed Mesodermal (Müllerian) Tumor with Neuroendocrine Differentiation

Retrovesical desmoplastic small round cell tumor in a patient with urinary frequency

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