Desmoplastic Primitive Nonneural Granular Cell Tumor of the Skin

Agustí, Jaime; Martínez-Ciarpaglini, Carolina; Monteagudo, Carlos

doi:10.1097/dad.0b013e318296fe84

Cited by 9 publications

(13 citation statements)

References 8 publications

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“…When no specific line of differentiation can be proved in a GCT, a diagnosis of NN‐GCT has to be considered …”

Section: Resultsmentioning

confidence: 99%

“…The only consistent diffuse cytoplasmic staining was for antibody NK1‐C3, a very sensitive marker of granular cell change, irrespective of histogenesis . Some of these lesions may have prominent desmoplastic stroma . NN‐GCT has a good prognosis and should be considered benign.…”

Section: Tumors That Can Exhibit Granular Cell Changementioning

confidence: 99%

“…Immunohistochemically, a specific lineage of cellular differentiation is not apparent, and NN‐GCT is considered a diagnosis of exclusion . They are negative for S100 protein (easily distinguished from conventional GCT), SMA, desmin, CD34, cytokeratins and melanocytic markers (HMB‐45 or Melan‐A).…”

Section: Tumors That Can Exhibit Granular Cell Changementioning

confidence: 99%

“…Local recurrence is possible and therefore complete excision is advised . The clinical evolution is typically indolent, with three cases reporting lymph node metastasis . Hence, appropriate follow up should be instituted in all patients both for surveillance and to allow further characterization of the behavior of this uncommon neoplasm …”

Section: Tumors That Can Exhibit Granular Cell Changementioning

confidence: 99%

“…33 Some of these lesions may have prominent desmoplastic stroma. 34 NN-GCT has a good prognosis and should be considered benign. Local recurrence is possible and therefore complete excision is advised.…”

Section: Dermal Non-neural Gctmentioning

confidence: 99%

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Granular cell differentiation: A review of the published work

Cardis

Bhawan

2017

The Journal of Dermatology

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Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. In light of this, it is important to be aware of the various entities that have been reported to exhibit granular cell morphology. In this review such tumors are discussed along with pertinent clinical and histopathological features.

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“…When no specific line of differentiation can be proved in a GCT, a diagnosis of NN‐GCT has to be considered …”

Section: Resultsmentioning

confidence: 99%

Section: Tumors That Can Exhibit Granular Cell Changementioning

confidence: 99%

Section: Tumors That Can Exhibit Granular Cell Changementioning

confidence: 99%

Section: Tumors That Can Exhibit Granular Cell Changementioning

confidence: 99%

Section: Dermal Non-neural Gctmentioning

confidence: 99%

See 3 more Smart Citations

Granular cell differentiation: A review of the published work

Cardis

Bhawan

2017

The Journal of Dermatology

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Solitary, multiple, benign, atypical, or malignant: the “Granular Cell Tumor” puzzle

et al. 2015

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The clinical evolution and biology of granular cell tumors (GCT) are poorly understood and treatment remains an issue of discussion. The majority of GCT are benign, although some display malignant behavior. The distinction between benign, atypical, and malignant GCT is controversial due to morphological and immunohistochemical overlap and lack of consistent histological and phenotypic criteria that predict behavior. Although histological criteria may indicate increased risk of malignant evolution, some GCT with evident benign appearance exceptionally progress towards metastatic disease. In this review, we discuss current knowledge on GCT, including histologic, immunophenotypic, and molecular characteristics and differential diagnosis. We focus on the following problematic items in GCT: (1) evolution of classification, (2) neural versus non-neural GCT, (3) neoplastic versus reactive disease, (4) malignant transformation of benign GCT, and (5) multiple versus metastatic GCT. We conclude that although a Ki-67 index >10 % and the presence of mitoses and/or of necrosis are frequently associated with malignant behavior, metastasis remains the only unequivocal sign of malignancy in GCT. An infiltrative growth pattern and vascular and/or perineural invasion are not indicative of malignancy. GCT with atypical/uncertain features almost never metastasize, and many of these tumors either behave in a benign fashion or only recur locally (similar to incompletely excised benign tumors). We therefore propose that classical and atypical histological variants form a single group of GCT. GCT with various unfavorable histological features might be labeled as "GCT with increased risk of metastasis" rather than malignant GCT.

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S-100 Negative Granular Cell Tumor of the Oral Cavity

Solomon

Velez

2015

Head and Neck Pathol

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Classic granular cell tumor is a mesenchymal neoplasm that commonly occurs on the skin, but is not infrequently found in the oral cavity, primarily on the dorsal tongue. Diagnosis is usually straightforward with hematoxylin and eosin stained slides. Immunohistochemical studies on classic granular cell tumor shows positive immunostaining for S-100 and vimentin, while CD68 is variably positive. We report a case of otherwise unremarkable oral granular cell tumor that was immunohistochemically negative for S-100, and positive for vimentin and CD68, and discuss the differential diagnosis. The results of the immunohistochemical studies in our case are compared with those of classic S-100 positive oral granular cell tumors, as well as cutaneous and oral S-100 negative granular cell tumors. Classic S-100 positive granular cell tumors and S-100 negative granular cell tumors of the oral cavity can only be distinguished by immunohistochemical studies; however, the necessity of this distinction is unclear, as both are benign lesions in which recurrence is unlikely.

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Desmoplastic Primitive Nonneural Granular Cell Tumor of the Skin

Cited by 9 publications

References 8 publications

Granular cell differentiation: A review of the published work

Granular cell differentiation: A review of the published work

Solitary, multiple, benign, atypical, or malignant: the “Granular Cell Tumor” puzzle

S-100 Negative Granular Cell Tumor of the Oral Cavity

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