Desmoplastic melanoma of the lower lip: A case report

Treacy, Simon; Traynor, Kathryn; Leonard, Niamh; Gilbride, Michael; Wilson, Mark W.

doi:10.1016/j.adoms.2021.100165

Cited by 2 publications

(1 citation statement)

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“…When it comes to treating mucosal melanomas, most authors advocate for wide local excision, in which clear margins are achieved with or without lymph node dissection [ 4 , 9 ]. However, complete resection of mucosal melanomas is difficult to achieve as they are often diagnosed at advanced clinical stages, and wide negative margins may be difficult due to anatomic constraints [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Mucosal Melanoma of the Lip With GNA11 Mutation in a 23-Year-Old Pregnant Woman

Khatri¹,

Kashfi²,

Griffin³

2023

Cureus

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Mucosal melanoma represents a small proportion of all melanoma cases and is associated with a worse prognosis. Primary malignant melanoma of the lip (PMML) is far less common, and only a few cases have been reported since 1997, most commonly in China, Japan, Uganda, and India. Most of these cases have been associated with the gene C-KIT. As a result, treatment guidelines surrounding mucosal melanoma are unclear, especially in complicated populations such as pregnant women. Mutations in theGNAQ and GNA11 genes have been found to be associated with uveal melanoma, while they are rarely associated with mucosal melanoma. We present the case of a 23-year-old pregnant woman who was found to have likely primary malignant melanoma of the lip that metastasized to the left jaw, neck, breast, lungs, and ovaries and was found to be positive for both the BRAF-MLL3 and GNA11 mutation.

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Section: Discussionmentioning

confidence: 99%