Desmoplastic malignant melanoma of the lip: A report of 6 cases and review of the literature

Hui, Jennifer I.; Linden, Kenneth G.; Barr, Ronald J.

doi:10.1067/mjd.2002.124686

Cited by 16 publications

(13 citation statements)

References 10 publications

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“…A wide range of ages exists in the literature, however, including a series of six patients in their mid-20's to 30's with DM of the lip, and a case report of an 18-year-old girl with a lesion on the buttock (14,22). A male predilection is reported by most, in the range of 1.7 to 2.2 to 1 (11,13,16,20).…”

Section: Discussionmentioning

confidence: 89%

“…A f i i f o fleshy painless papule, nodule, or plaque which is amelanotic in over 50% of cases, slow growing, and usually ranging from 0.5 to 6 cm in size are the classical features (1 1,13,14,16,19,25). They may clinically mimic a scar, fibroma, fibromatosis, neuro fibroma, epidermal inclusion cyst, basal cell carcinoma, benign mole, squamous cell carcinoma, rosacea, and many other benign and malignant entities (5,6,10,11,14,16,20,23,26). Mucosal or epidermal pigmentation overlying a palpable nodule may provide a clue to the correct diagnosis (19).…”

Section: Discussionmentioning

confidence: 99%

“…DM and Desmoplastic neurotropic melanoma (DNM) likely represent the same entity and will be discussed as such in the following review. Their definitions differ only regarding the histologic detection of neural invasion, which may be subject to sampling en-or (14).…”

Section: Discussionmentioning

confidence: 99%

“…Adequate surgical margins, adjuvant radiotherapy, and the use of sentinel lymph node (SLN) evaluation with follow-up directed to the detection of lung metastases have been proposed as appropriate treatment modalities (10)(11)(12)(13). Delay in treatment as a result of misdiagnosis and inadequate initial therapy leads to locoregional recurrences, increased risk of metastasis, and poor prognosis (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

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Desmoplastic Malignant Melanoma: Exposing the Great Masquerade

McLaren¹,

Ma²

2003

Journal of Histotechnology

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Desmoplastic malignant melanoma is a cutaneous neoplasm, which may present with a variety of subtle clinical and pathologic findings, leading to diagnostic confusion. Described first in 1971, efforts have been gradually successful at delineating the classical features and behavior of these tumors. Even so, without an acute awareness of these features and a heightened vigilance by clinicians and pathologists alike, many cases of desmoplastic melanoma may continue to be misdiagnosed andlor mismanaged. We have researched the available English literature to provide herein a comprehensive review of desmoplastic malignant melanoma. In nonpigmented lesions, careful attention to histologic detail must be accompanied by a thorough knowledge of pertinent features, which may aid in distinction from other spindled neoplasms. The use of immunohistochemistry must be stressed not only as an adjunct in the differential diagnosis but also as a tool to more accurately determine clinical stage and margin status. Additionally, we must seek a more unified therapeutic approach based on the known clinical behavior of these tumors. The prognosis of desmoplastic melanoma critically depends on timely clinical attention, accurate pathologic diagnosis, and prompt, effective treatment regimens. (The J Histotechnol26:245, 2003)

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Desmoplastic Malignant Melanoma: Exposing the Great Masquerade

McLaren¹,

Ma²

2003

Journal of Histotechnology

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show abstract

“…Physicians should consider the possibility of desmoplastic malignant melanoma in young people who present with atypical lip lesions, which, on histopathologic analysis, demonstrate spindlecell hyperplasia. 9 Although we may never reach perfection in our pursuit of accurately diagnosing melanoma, by being vigilant for subtle clinical clues, using dermoscopy, photography (either standard or digital), and performing biopsies on those lesions with a history of change, we should be less likely to misdiagnose melanoma. For dermatopathogists, Drs Xu and Elder 1 believe that scanning power examination alone is insufficient to avoid the potential diagnostic pitfalls in melanocytic lesions.…”

mentioning

confidence: 99%