Desmoplastic malignant melanoma of the gingiva: Case report and review of the literature

Ueta, Eisaku; Miki, T; Osaki, Tokio; Iwata, Jun; Shinmoto, Hiroshi

doi:10.1016/s0964-1955(96)00036-x

Cited by 13 publications

(9 citation statements)

References 10 publications

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“…Since then, several desmoplastic OMM has been the subject of case reports [24][25][26][27][28]; therefore, it is difficult to understand its real incidence. In the present series, even if small, all the cases were predominantly composed of spindle cells intermingled with collagen bundles, indicating that probably these features are not so rare in OMM.…”

Section: Discussionmentioning

confidence: 99%

Genetic markers of oral malignant melanoma analysed by fluorescence in situ hybridisation (FISH)

et al. 2011

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Oral malignant melanoma (OMM) is a rare condition, and our knowledge about morphological and genetic modifications is scanty and incomplete. The aim of this study is to report morphological and fluorescent in situ hybridisation (FISH) data obtained in four cases of OMM. FISH results were also compared with those of cutaneous malignant melanoma (CMM, three cases), desmoplastic cutaneous melanoma (DMM, four cases) and spindle cells cutaneous melanoma (SCCM, one case). All the OMM cases showed a combined radial and vertical growth pattern, with the invasive component characterised by malignant spindle cells intermingled among collagen bundles. Two cases of OMM resulted positively stained with p16, in contrast with frequent loss of immunoreactivity in CMM. Three OMM were suitable for FISH analysis: 9p21 locus was deleted in 1/3, 1p36 resulted deleted 3/3, while EGFR gene showed a relative deletion. Similar genetic alterations were found in DMM and SCMM, but not in CMM. Ultrastructural findings further enhanced differences between OMM and CMM; OMM displayed, mature-staged melanosomes only within in situ component. In conclusion, OMM presents a morphological and genetic profile similar to DMM; and SCCM, however, displays some differences from CMM.

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Section: Discussionmentioning

confidence: 99%

Genetic markers of oral malignant melanoma analysed by fluorescence in situ hybridisation (FISH)

et al. 2011

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“…3,4,[11][12][13][14] Many authors have advocated generous surgical margins of up to 3 cm as a means to reduce the rate of local recurrences of DMM. [2][3][4]6,9 However, most lesions present in the head and neck, 5,9,10,15,16 where wide surgical excision can be associated with poor functional and cosmetic outcome. It should also be noted that even with negative surgical margins the rate of recurrence was still 40%.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of radiation therapy in the local control of desmoplastic malignant melanoma

et al. 2003

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“…Among the 20 patients identified in our literature search 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 , including ours, the average age at diagnosis was 53.6 years. Although the sixth decade of life was the most frequent age affected, patients aged 20 to 90 years were diagnosed with the disease.…”

Section: Resultsmentioning

confidence: 88%

“…Three were excluded: 2 involved cases of desmoplastic melanoma that were present only in metastatic lymph nodes, and 1 was in Italian. Finally, 20 cases of oral desmoplastic melanoma were identified, including 1 case that we encountered and others from 16 relevant articles 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 . Data on clinical features, histopathologic features, diagnostic features, treatment, and prognosis were collected from each study.…”

Section: Methodsmentioning

confidence: 99%

Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics

Min

Jeong

Ahn

et al. 2018

J Korean Assoc Oral Maxillofac Surg

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ObjectivesDesmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanotic benign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review.Materials and MethodsWe analyzed 19 desmoplastic melanoma cases reported in the literature and added our experience. Data on clinical, histopathology, treatment, and survival were retrieved and analyzed. Survival analysis was by the Kaplan-Meier method.ResultsInitial clinical and histopathological features were indistinctive, and a definite diagnosis of desmoplastic melanoma at initial assessment was possible in only 23.5% of cases. Among tests, immunohistochemical studies for S-100 and vimentin were all positive. The 5-year disease-free survival rate for oral desmoplastic melanoma was 0%, and the 5-year overall survival rate was 55.0%.ConclusionOral desmoplastic melanoma has a high percentage of initial misdiagnosis and propensity for local recurrence. Thus, careful initial diagnosis and adequate surgery may result in improved overall survival.

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Desmoplastic malignant melanoma of the gingiva: Case report and review of the literature

Cited by 13 publications

References 10 publications

Genetic markers of oral malignant melanoma analysed by fluorescence in situ hybridisation (FISH)

Genetic markers of oral malignant melanoma analysed by fluorescence in situ hybridisation (FISH)

Efficacy of radiation therapy in the local control of desmoplastic malignant melanoma

Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics

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