Desmoplastic fibroma of the mandible in young children—a case series

Khatib, Baber; Pogrel, M. Anthony

doi:10.1016/j.ijom.2016.09.018

Cited by 15 publications

(22 citation statements)

References 15 publications

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“…In additional, desmoplastic fibroma may mimic fibromyxoma histologically. Desmoplastic fibromas are rare aggressive intraosseous lesions that are seen more commonly in the mandible [38]. This neoplasm is comprised of proliferative spindle cells within a bland collagenous stroma.…”

Section: Differential Diagnosis: Histopathologymentioning

confidence: 99%

Fibromyxoma of the Jaw: Case Report and Review of the Literature

Alhousami

Sabharwal

Gupta

et al. 2017

Head and Neck Pathol

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We report a case of fibromyxoma of the mandible, a rare benign odontogenic tumor. Our patient presented in the first trimester of pregnancy with a large mass in the right body of the mandible exhibiting displacement of teeth and destruction of an extensive area of the mandibular bone. The mass was biopsied and diagnosed as a fibromyxoma. The large size of the tumor dictated a wide mandibular resection. We will review the clinical, radiographic, and histologic features of fibromyxoma and discuss its differential diagnoses. In addition, we will provide an overview of patient management. Fibromxyoma is a benign gnathic tumor that can be locally aggressive. To ensure appropriate treatment, it is important to distinguish this neoplasm from other mimickers in which myxoid, spindle mesenchymal cell proliferation is prominent.

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Section: Differential Diagnosis: Histopathologymentioning

confidence: 99%

Fibromyxoma of the Jaw: Case Report and Review of the Literature

Alhousami

Sabharwal

Gupta

et al. 2017

Head and Neck Pathol

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“…Meanwhile, Woods et al in 2015, evaluated 152 gnathic desmoplastic fibromas and stated that the tendency to occur in women is 56% greater, with most cases under the age of 30 while the location in mandibular posterior was favored by 84%. 17 However, when Evans HL in 1995, described the desmoplasticic fibroma, only ten cases (PubMed and LILACS) were reported within the oral cavity due to the tumor effects on mainly soft tissue while the intraosseous manifestations as described in this study are rare. 20 Meanwhile, among the ten cases of desmoplastic fibroma of the oral cavity, only one described by Jaafari-Ashkavandi Z et al, was intraosseous and located in the maxillary alveolar bone.…”

Section: Discussionmentioning

confidence: 60%

“…16 Griffith and Irby in 1965 reported the first case of jaw bone desmoplastic fibroma that occurred in the mandible of an 8 year old girl. 17 Moreover, the desmoplastic fibroma lesions are usually painless, slowgrowing and asymptomatic swellings. 12,18 Furthermore, facial asymmetry, tooth displacement, root divergence, pain, trismus and infections are other symptoms.…”

Section: Discussionmentioning

confidence: 99%

Desmoplastic Fibroma and Cemento Ossifying Fibroma of The Anterior Maxilla: A Rare Case Report

2021

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Tumors located in the maxillofacial part of the body were classified by WHO in 2017 and among these are intraosseous form of fibromatosis known as Desmoplastic and Cemento-ossifying fibromas. These tumors usually occur in the head and neck region, especially in the mandible and are relatively rare in the maxilla. Meanwhile, this study aims to discribe a rare case of the cemento ossifying fibroma that had been previously diagnosed as desmoplastic fibroma with a mass tumor in the anterior of the maxilla. A 22 years old female reported to the Cipto Mangkusumo Hospital with the main complaint of a lump in the right side of the upper jaw which appeared 2 years prior to the operation. In April 2017, the patient had a biopsy in Tarakan Hospital and the result was a desmoplastic fibroma. Due to the lump enlargement, the patient was admitted to RSCM in July 2019 and had biopsy incision with a diagnosis of cemento ossifying fibroma which was confirmed by the histopathological examination and histology report. The resection of the right part of maxilla was conducted alongside with reconstruction using the free fibular flap. Moreover, cemento ossifying fibroma and desmoplastic fibroma shared similar features, namely, clinical, histological and radiological features which are important in establishing the diagnosis and treatment of patient. Hence, extensive enucleation or resection is required due to the progressive nature of the tumor to prevent the potential for further recurrences.

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“…Anecdotal reports of successful use of radiotherapy in patients with DF are available, though these cases were of DF involving the lower limbs and not the gnathic bones 53 , 54. A wide range of complications have been described in cases of DF ranging from difficulty in mouth opening, extension into the adjacent soft tissue, perineural encasement, loosening of the overlying tooth, dysfunction of the temporomandibular joint, sinusitis, and nasal obstruction 1 , 8 , 13 , 22 , 23 , 25 , 27 , 28 , 32 , 36 , 41 , 42 , 44. All the complications are secondary to the aggressive nature of the tumor and the mass effect.…”

Section: Discussionmentioning

confidence: 99%

Desmoplastic fibroma of the mandible: a rare gnathic bone tumor with a review of the literature

2019

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Desmoplastic fibroma (DF) is a rare bone tumor, which is known to involve mostly the gnathic bones. In this setting, the clinical presentation is usually represented by a bulging tumor of the face. Radiologically, the tumor is usually characterized by an expansile lytic bone lesion. The histopathology of the tumor shows a poorly circumscribed hypocellular lesion rich in collagen fibers with interspersed spindle cells having bland nuclear chromatin. Despite the lack of mitoses and nuclear pleomorphism, DF has an aggressive nature, presenting as a destructive growth causing entrapment of neuro-vascular bundles, sinusitis, or trismus. Some cases of DF show mutations in the adenomatous polyposis coli pathway shown by nuclear localization of the β-catenin protein. Few reports showed an association with tuberous sclerosis, though most of these cases were sporadic. We discuss a rare case of desmoplastic fibroma involving the mandible, and a review of the literature of the DF cases involving the gnathic bones.

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Desmoplastic fibroma of the mandible in young children—a case series

Cited by 15 publications

References 15 publications

Fibromyxoma of the Jaw: Case Report and Review of the Literature

Fibromyxoma of the Jaw: Case Report and Review of the Literature

Desmoplastic Fibroma and Cemento Ossifying Fibroma of The Anterior Maxilla: A Rare Case Report

Desmoplastic fibroma of the mandible: a rare gnathic bone tumor with a review of the literature

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