Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy

Zippi, Maddalena; Toma, Giorgio De; Minervini, G.; Cassieri, C.; Pica, Roberta; Colarusso, Diodoro; Stock, Simon; Crispino, Pietro

doi:10.4103/1319-3767.199114

Cited by 24 publications

(19 citation statements)

References 27 publications

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“…Colon cancer had an upward trend of the incidence worldwide [ 47 ]. Although surgical treatment has made great progress, but the five-year overall survival of colon cancer is still hovering around 50% [ 48 ]. In recent years, chemotherapy can prolong the lives of patients and improve the patients' quality of life [ 49 ]; nevertheless, the commonly chemotherapeutic regimens often seriously impair the life quality of the patients and cause serious constraints on the use of chemotherapeutic drugs.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Compound Kushen Injection on Patients with Advanced Colon Cancer: A Meta‐Analysis of Randomized Controlled Trials

Zhou

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Objective The efficacy and safety of Compound Kushen Injection (CKI) on advanced colon cancer remain controversial. We undertook a systematic meta-analysis of randomized controlled clinical studies on this issue. Methods A comprehensive literature search was conducted by searching the following electronic databases: PubMed, Cochrane, Chinese Biological Medical disc, Chinese National Knowledge Infrastructure, and Wan-Fang Database in China by the end of January 31, 2017, without language restriction. Meta-analysis was performed by using the random effects model to estimate the summary odd ratio (OR) with 95% confidence interval (CI) according to the study design. Stata 12.0 software was used for data analysis. The heterogeneity, sensitivity, and publication bias were assessed, respectively. Results A total of 14 trials met the inclusion criteria in present meta-analysis. The results suggested that CKI combined with chemotherapeutic drugs was favorable for the treatment of advanced colon cancer and could improve the patients' life quality. Funnel plot analysis and Egger's test suggested that there was not significant publication bias, and the sensitivity analysis indicated stable results. Conclusion The current evidence suggested that CKI is favorable to improve the efficacy of chemotherapeutic drugs in patients with advanced colon cancer.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Compound Kushen Injection on Patients with Advanced Colon Cancer: A Meta‐Analysis of Randomized Controlled Trials

Zhou

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…Surgery is the primary treatment for colorectal cancer. 1 , 2 Colorectal cancer often metastasizes to lymph nodes, so lymphadenectomy is the key factor influencing the prognosis. 3 – 7 …”

Section: Introductionmentioning

confidence: 99%

Clinical application of carbon nanoparticles in curative resection for colorectal carcinoma

Wang

Zhou

Zheng

et al. 2017

OTT

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PurposeTo explore the potential of carbon nanoparticles (CNs) for the intraoperative detection of positive and negative lymph nodes in the treatment of colorectal cancer.Patients and methodsThe clinical data of 470 patients undergoing surgical procedures for colorectal cancer from June 2010 to February 2013 were analyzed retrospectively. The patients were divided into the CN group (183 males and 161 females; mean age, 58.6±12.4 years), who were given a CN suspension, and the control group (78 males and 48 females; mean age, 59.1±12.2 years), who were not given a CN suspension. The operative time, blood loss, number of lymph nodes detected/positive lymph nodes, and prevalence of postoperative complications were compared between the two groups. Three years after surgery, 444 cases (327 cases in the CN group and 117 cases in the control group) were interviewed, with the remaining 26 cases lost to follow-up. With regard to tumor, node, metastasis staging, the survival and prevalence of recurrence in each group at 3 years were analyzed.ResultsThe number of positive lymph nodes was higher and the prevalence of blood loss was lower in the CN group than in the control group (p<0.05). There were no significant differences in the operative time, number of lymph nodes detected, or the prevalence of postoperative complications, survival, metastasis, or recurrence between the two groups at 3 years (p>0.05).ConclusionThe application of CNs is convenient for the detection of lymph nodes to reduce blood loss and increase the probability of detecting positive lymph nodes accurately and rapidly.

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“…Radical colorectal surgery is the main treatment for colorectal cancer [1]. The lymph node is the main way of colorectal cancer metastasis, so, it has a prognosis and therapeutic importance to stage lymph node metastasis accurately in patients with colorectal cancer [2].…”

Section: Introductionmentioning

confidence: 99%

Carbon Nanoparticles for Identifying Lymph Nodes during Surgery in Colorectal Cancer: A Meta-Analysis

Miao¹,

Shen²,

Li³

et al. 2019

JCT

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Aim: To investigative the efficacy of carbon nanoparticles (CNs) to identify the lymph nodes during radical surgery in colorectal cancer. Method: The MEDLINE, EMBASE and Cochrane Library databases were searched electronically to identify the studies that compared the use of CNs (CN group) with control group in patients undergoing colorectal cancer radical surgery (from January 2009 to November 2018). The primary outcome was the number of retrieved central lymph nodes. Results: This meta-analysis identified 2 randomized controlled trials and 5 non-randomized controlled trials. Compared with the control group, the CN group resulted in an average of 7.16 more lymph nodes removed per patient

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Desmoplasia influenced recurrence of disease and mortality in stage III colorectal cancer within five years after surgery and adjuvant therapy

Cited by 24 publications

References 27 publications

Efficacy and Safety of Compound Kushen Injection on Patients with Advanced Colon Cancer: A Meta‐Analysis of Randomized Controlled Trials

Efficacy and Safety of Compound Kushen Injection on Patients with Advanced Colon Cancer: A Meta‐Analysis of Randomized Controlled Trials

Clinical application of carbon nanoparticles in curative resection for colorectal carcinoma

Carbon Nanoparticles for Identifying Lymph Nodes during Surgery in Colorectal Cancer: A Meta-Analysis

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