Desmoid Tumors of the Pelvis and Abdominal Wall

Powell, John L.; Ross, Shannan C.; Henderson, Gregory S.; Neal, Charles R.

doi:10.1097/01.spv.0000101030.60921.9f

Cited by 1 publication

(7 citation statements)

References 19 publications

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“…Case Reports in Obstetrics and Gynecology regressing lesions to rapidly growing tumors [10,12]. Most are asymptomatic until organ dysfunction is present [8].…”

Section: Discussionmentioning

confidence: 99%

“…Targeted therapies are being studied, such as sorafenib and pazopanib [8,13]. Also, there have been some experiences with other therapies like nonsteroidal and steroidal anti-inflammatory drugs, tamoxifen, and cytotoxic chemotherapeutic drugs [3][4][5]10].…”

Section: Discussionmentioning

confidence: 99%

“…Regarding pathophysiology, desmoid tumors represent an infiltrative fibroproliferation disorder in the fascia and muscle aponeurosis [ 1 , 3 , 10 ]. They may develop in any body site but most frequently appear in the anterior abdominal wall and shoulder girdle [ 1 , 3 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Desmoid tumors may develop in any body site, but the majority (60%) are localized in extra-abdominal areas, especially the abdominal wall [3,6,8]. Retroperitoneal pelvic desmoid tumors are even rarer [7,9,10]. They are usually diagnosed as a deep infiltrative mass, sometimes palpable, but asymptomatic otherwise, until they cause visceral compression, leading to vascular, urinary, enteric, and/or neural manifestations [1][2][3]11].…”

Section: Introductionmentioning

confidence: 99%

“…Because of the rarity of these tumors, only 50% of them are properly diagnosed before surgery. Frequent differential diagnosis encompasses ovarian neoplasms, sarcoma, GIST, endometriosis, and organized hematoma [5][6][7]10]. Evidence-based treatment guidelines are nonexistent, and most data is encountered in case reports and small cohorts [5].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Pelvic Desmoid Tumor: A Rare Case with Difficult Diagnosis and Treatment

Ormonde

Argyropoulou

Lourenço

et al. 2022

Case Reports in Obstetrics and Gynecology

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Desmoid tumors are rare benign neoplasms, with locally aggressive characteristics. Ongoing or previous pregnancy, antecedent trauma, and familial adenomatous polyposis are known risk factors. Still, the majority of cases are sporadic and its etiology is still unknown. These tumors may occur in any body site, but retroperitoneal and pelvic desmoid tumors are extremely rare. Nonspecific clinical and radiological findings lead to erroneous diagnosis in 50% of patients before surgery. We present a case of a young multiparous female with a deep infiltrative lesion adherent to the right pelvic sidewall leading to severe right hydroureteronephrosis and ipsilateral loss of renal function. Although deep endometriosis was suspected, malignancy features could not be excluded by imaging studies. The patient underwent an exploratory laparotomy for definite diagnosis and treatment, which led to right nephrectomy, hysterectomy, and right oophorectomy because of deep infiltration and difficult dissection. Definite histologic diagnosis revealed the presence of a pelvic desmoid tumor. Positive margins were encountered but, until this moment, no disease relapse occurred.

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“…Case Reports in Obstetrics and Gynecology regressing lesions to rapidly growing tumors [10,12]. Most are asymptomatic until organ dysfunction is present [8].…”

Section: Discussionmentioning

confidence: 99%