Desmoid fibromatosis in children and adolescents: A conservative approach to management

Systemic therapy of aggressive fibromatosis in children and adolescents: Report of the Cooperative Weichteilsarkom Studiengruppe (CWS)

“…Due to the morbidity and high recurrence rates seen in children and adolescents following adequate local treatment, ST is often administered prior to or following local therapy in cases of disease progression . Several recent publications reported response rates of 27–63% to systemic therapies in pediatric patients and concluded that low‐dose chemotherapy (CHT) could be proposed as a form of adjuvant therapy .…”

Desmoid tumor in a laparotomy scar in a child: Case report and brief literature review

“…Conversely, another study by Oudot et al of 59 children with AF reported local trauma as a predisposing factor in only three (5%) cases [21]. Honeyman et al recently studied 93 children with DT [22], of whom 17 (18%) were reported to have a history of preceding trauma. The scant reports of DTs emanating from a laparotomy scar [15,[23][24][25] quote an estimated incidence of less than 0.05% (220 of the total DTs examined).…”

Is Wide Resection Obsolete for Desmoid Tumors in Children and Adolescents? Evaluation of Histological Margins, Immunohistochemical Markers, and Review of Literature

“…This finding is supported by Soto-Miranda et al [11], who state that margin status is not a prognostic marker for local recurrence in their collective of 39 patients. In recent years several authors have recommended an initial wait and see policy for nonor slowly growing tumors that are clinically asymptomatic [14].…”

“…The first-line treatment still remains surgery, as wide or radical excision was found to be the most successful primary treatment modality [9] and a significant prognostic factor in adult patients [10]. However, the influence of surgical treatment has recently been discussed controversially in literature with an increasing argument for non-surgical management [11][12][13][14]. Due to infiltrative growth patterns and the tendency towards local recurrence, desmoid fibromatosis especially poses a challenge for pediatric and adolescent patient collectives.…”